IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder.
IL-38
amygdala
autism
inflammation
microglia
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
pubmed:
1
7
2020
medline:
22
9
2020
entrez:
1
7
2020
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1β and CXCL8. This process is inhibited by the cytokine IL-37. Another cytokine, IL-38, has been reported to have antiinflammatory actions. In this report, we show that pretreatment of cultured adult human microglia with recombinant IL-38 (aa3-152, 1-100 ng/mL) inhibits (
Identifiants
pubmed: 32601180
pii: 2004666117
doi: 10.1073/pnas.2004666117
pmc: PMC7368277
doi:
Substances chimiques
CXCL8 protein, human
0
IL-38 protein, human
0
Interleukin-16
0
Interleukin-1beta
0
Interleukin-8
0
Interleukins
0
Neurotensin
39379-15-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16475-16480Déclaration de conflit d'intérêts
The authors declare no competing interest.
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