A tumor-associated splice-isoform of
JNK inhibitors
MAP2K7
MBNL1
alternative splicing
tumor cell dedifferentiation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
pubmed:
1
7
2020
medline:
22
9
2020
entrez:
1
7
2020
Statut:
ppublish
Résumé
Master splicing regulator MBNL1 shapes large transcriptomic changes that drive cellular differentiation during development. Here we demonstrate that MBNL1 is a suppressor of tumor dedifferentiation. We surveyed
Identifiants
pubmed: 32601196
pii: 2002499117
doi: 10.1073/pnas.2002499117
pmc: PMC7368273
doi:
Substances chimiques
MBNL1 protein, human
0
Protein Isoforms
0
RNA-Binding Proteins
0
MAP Kinase Kinase 4
EC 2.7.12.2
MAP Kinase Kinase 7
EC 2.7.12.2
MAP2K7 protein, human
EC 2.7.12.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16391-16400Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: D.R is an inventor on a patent “Stratification of Cancer Patients by MBNL1 and MAP2K7Δexon2 Expression for Susceptibility to JNK Inhibition” filed in the Singapore patent office, Provisional Application No. 10201910208U. D.M.E is the founder, director, and CEO of Black Diamond Therapeutics and a consultant to Engine Bioscience in areas unrelated to this manuscript.
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