Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Arthritis, Rheumatoid
/ genetics
Biopsy
Cell Lineage
/ genetics
Humans
Inflammation
/ genetics
Joints
/ immunology
Lectins, C-Type
/ genetics
Macrophages
/ immunology
Mannose Receptor
Mannose-Binding Lectins
/ genetics
Receptors, Cell Surface
/ genetics
Receptors, Immunologic
/ genetics
Synovial Fluid
/ immunology
Synovial Membrane
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
23
09
2019
accepted:
12
05
2020
pubmed:
1
7
2020
medline:
29
10
2020
entrez:
1
7
2020
Statut:
ppublish
Résumé
Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each clinical state was characterized by different frequencies of nine discrete phenotypic clusters within four distinct STM subpopulations with diverse homeostatic, regulatory and inflammatory functions. This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTK
Identifiants
pubmed: 32601335
doi: 10.1038/s41591-020-0939-8
pii: 10.1038/s41591-020-0939-8
doi:
Substances chimiques
Lectins, C-Type
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Receptors, Immunologic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1295-1306Subventions
Organisme : Medical Research Council
ID : MR/S025308/1
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21802
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21890
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 22253
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800648
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
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