The IMAGEN study: a decade of imaging genetics in adolescents.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
05
05
2019
accepted:
12
06
2020
revised:
10
04
2020
pubmed:
1
7
2020
medline:
16
3
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
Identifiants
pubmed: 32601453
doi: 10.1038/s41380-020-0822-5
pii: 10.1038/s41380-020-0822-5
pmc: PMC7577859
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2648-2671Subventions
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N027558/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700704
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Investigateurs
Lisa Albrecht
(L)
Chris Andrew
(C)
Mercedes Arroyo
(M)
Eric Artiges
(E)
Semiha Aydin
(S)
Christine Bach
(C)
Tobias Banaschewski
(T)
Alexis Barbot
(A)
Gareth Barker
(G)
Nathalie Boddaert
(N)
Arun Bokde
(A)
Zuleima Bricaud
(Z)
Uli Bromberg
(U)
Ruediger Bruehl
(R)
Christian Büchel
(C)
Arnaud Cachia
(A)
Anna Cattrell
(A)
Patricia Conrod
(P)
Patrick Constant
(P)
Jeffrey Dalley
(J)
Benjamin Decideur
(B)
Sylvane Desrivieres
(S)
Tahmine Fadai
(T)
Herta Flor
(H)
Vincent Frouin
(V)
Jürgen Gallinat
(J)
Hugh Garavan
(H)
Fanny Gollier Briand
(FG)
Penny Gowland
(P)
Bert Heinrichs
(B)
Andreas Heinz
(A)
Nadja Heym
(N)
Thomas Hübner
(T)
James Ireland
(J)
Bernd Ittermann
(B)
Tianye Jia
(T)
Mark Lathrop
(M)
Dirk Lanzerath
(D)
Claire Lawrence
(C)
Hervé Lemaitre
(H)
Katharina Lüdemann
(K)
Christine Macare
(C)
Catherine Mallik
(C)
Jean-François Mangin
(JF)
Karl Mann
(K)
Jean-Luc Martinot
(JL)
Eva Mennigen
(E)
Fabiana Mesquita de Carvahlo
(FM)
Xavier Mignon
(X)
Ruben Miranda
(R)
Kathrin Müller
(K)
Frauke Nees
(F)
Charlotte Nymberg
(C)
Marie-Laure Paillere
(ML)
Tomas Paus
(T)
Zdenka Pausova
(Z)
Jean-Baptiste Poline
(JB)
Luise Poustka
(L)
Michael Rapp
(M)
Gabriel Robert
(G)
Jan Reuter
(J)
Marcella Rietschel
(M)
Stephan Ripke
(S)
Trevor Robbins
(T)
Sarah Rodehacke
(S)
John Rogers
(J)
Alexander Romanowski
(A)
Barbara Ruggeri
(B)
Christine Schmäl
(C)
Dirk Schmidt
(D)
Sophia Schneider
(S)
MarkGunter Schumann
(M)
Florian Schubert
(F)
Yannick Schwartz
(Y)
Michael Smolka
(M)
Wolfgang Sommer
(W)
Rainer Spanagel
(R)
Claudia Speiser
(C)
Tade Spranger
(T)
Alicia Stedman
(A)
Sabina Steiner
(S)
Dai Stephens
(D)
Nicole Strache
(N)
Andreas Ströhle
(A)
Maren Struve
(M)
Naresh Subramaniam
(N)
Lauren Topper
(L)
Henrik Walter
(H)
Robert Whelan
(R)
Steve Williams
(S)
Juliana Yacubian
(J)
Monica Zilbovicius
(M)
C Peng Wong
(CP)
Steven Lubbe
(S)
Lourdes Martinez-Medina
(L)
Alinda Fernandes
(A)
Amir Tahmasebi
(A)
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