Antihyperglycemic Potential of Matricaria pubescens (Desf.) Schultz. in Streptozotocin-induced Diabetic Rats.
Antihyperglycemic
Matricaria pubescens
antioxidant
aqueous extract
histopathology
streptozotocin
Journal
Cardiovascular & hematological disorders drug targets
ISSN: 2212-4063
Titre abrégé: Cardiovasc Hematol Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269160
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
12
2019
revised:
22
04
2020
accepted:
28
05
2020
pubmed:
1
7
2020
medline:
4
6
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
The study aimed to investigate the antihyperglycemic activity of Matricaria pubescens. Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco. The present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens). The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay. The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro antioxidant activity of AEAPMP has been shown. In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.
Sections du résumé
AIMS
The study aimed to investigate the antihyperglycemic activity of Matricaria pubescens.
BACKGROUND
Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco.
OBJECTIVE
The present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).
METHODS
The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay.
RESULTS
The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro antioxidant activity of AEAPMP has been shown.
CONCLUSION
In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.
Identifiants
pubmed: 32603288
pii: CHDDT-EPUB-107789
doi: 10.2174/1871529X20666200630112610
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-304Informations de copyright
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