Molecular Mechanisms of Merkel Cell Polyomavirus Transformation and Replication.
Merkel cell carcinoma
Merkel cell polyomavirus
oncogenesis
replication
transformation
tropism
Journal
Annual review of virology
ISSN: 2327-0578
Titre abrégé: Annu Rev Virol
Pays: United States
ID NLM: 101625721
Informations de publication
Date de publication:
29 09 2020
29 09 2020
Historique:
pubmed:
1
7
2020
medline:
23
7
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Viral infection underlies a significant share of the global cancer burden. Merkel cell polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its discovery over a decade ago marked the beginning of an exciting era in human tumor virology. Since then, significant evidence has emerged to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of skin cancer. MCPyV infection is widespread in the general population. MCC diagnoses have tripled over the past 20 years, but effective treatments are currently lacking. In this review, we highlight recent discoveries that have shaped our understanding of MCPyV oncogenic mechanism and host cellular tropism, as well as the molecular events occurring in the viral infectious life cycle. These insights will guide future efforts in developing novel virus-targeted therapeutic strategies for treating the devastating human cancers associated with this new tumorigenic virus.
Identifiants
pubmed: 32603631
doi: 10.1146/annurev-virology-011720-121757
pmc: PMC7811827
mid: NIHMS1661427
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-307Subventions
Organisme : NIAMS NIH HHS
ID : R21 AR074073
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187718
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016520
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149761
Pays : United States
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