Prevalence of O25b-ST131 clone and fosfomycin resistance in urinary Escherichia coli isolates and their relation to CTX-M determinant.
Amikacin
/ pharmacology
Anti-Bacterial Agents
/ pharmacology
Ceftriaxone
/ pharmacology
Cefuroxime
/ pharmacology
Ciprofloxacin
/ pharmacology
DNA, Bacterial
/ genetics
Drug Resistance, Multiple, Bacterial
/ genetics
Escherichia coli
/ drug effects
Escherichia coli Infections
/ epidemiology
Escherichia coli Proteins
/ genetics
Fosfomycin
/ pharmacology
Humans
Meropenem
/ pharmacology
Microbial Sensitivity Tests
Polymerase Chain Reaction
Prevalence
Urinary Tract Infections
/ epidemiology
Virulence Factors
/ genetics
beta-Lactamases
/ genetics
Beta-lactamases
Fosfomycin
H30-R/ H30-Rx subclone
ST131 clone
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
10
01
2020
revised:
30
04
2020
accepted:
26
05
2020
pubmed:
1
7
2020
medline:
13
3
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Escherichia coli ST131 clone and H30-R/H30-Rx subclones are the most common multidrug-resistant high-risk clones in UTIs. Antimicrobial susceptibility of fosfomycin was compared to five other agents in consecutively collected 299 urinary isolates using the agar dilution method. Prevalence of the ST131 clone and the occurrence of blaCTX-M were also investigated. Overall resistance to fosfomycin, cefuroxime, and ceftriaxone were 2.7%, 35.4%, and 30.1% respectively. fosA, fosA3, and fosC2 genes were not detected. In isolates resistant to ciprofloxacin (34.7%), the prevalence of ST131 clone was 31.7%, of which 81.8% belonged to H30-R and 66.7% to H30-Rx subclones. None of the isolates of the ST131 clone were resistant to fosfomycin. However, bla
Identifiants
pubmed: 32603974
pii: S0732-8893(20)30475-2
doi: 10.1016/j.diagmicrobio.2020.115098
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
DNA, Bacterial
0
Escherichia coli Proteins
0
Virulence Factors
0
Fosfomycin
2N81MY12TE
Ciprofloxacin
5E8K9I0O4U
Ceftriaxone
75J73V1629
Amikacin
84319SGC3C
beta-Lactamases
EC 3.5.2.6
beta-lactamase CTX-M, E coli
EC 3.5.2.6
Meropenem
FV9J3JU8B1
Cefuroxime
O1R9FJ93ED
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115098Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.