Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study.
Aged
Betacoronavirus
/ isolation & purification
Blood Coagulation
COVID-19
Coronavirus Infections
/ blood
Correlation of Data
Critical Care
/ methods
Female
Humans
Intensive Care Units
/ statistics & numerical data
Iron
/ metabolism
Italy
/ epidemiology
Lymphocyte Count
/ methods
Lymphocyte Subsets
Lymphocytes
/ immunology
Male
Middle Aged
Mortality
Pandemics
Pneumonia, Viral
/ blood
SARS-CoV-2
Severity of Illness Index
Transferrin
/ analysis
COVID-19
Coagulation
Coronavirus
Critical care
Ferritins
Immunity
Iron
Lymphocytes
Lymphopenia
MeSH repository (3-10)
SARS-CoV-2
Journal
World journal of emergency surgery : WJES
ISSN: 1749-7922
Titre abrégé: World J Emerg Surg
Pays: England
ID NLM: 101266603
Informations de publication
Date de publication:
30 06 2020
30 06 2020
Historique:
received:
29
04
2020
accepted:
22
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
16
7
2020
Statut:
epublish
Résumé
Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis. Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 10 The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
Sections du résumé
BACKGROUND
Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis.
METHODS
We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis.
RESULTS
Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 10
CONCLUSIONS
The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
Identifiants
pubmed: 32605582
doi: 10.1186/s13017-020-00323-2
pii: 10.1186/s13017-020-00323-2
pmc: PMC7324776
doi:
Substances chimiques
Transferrin
0
Iron
E1UOL152H7
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
41Références
J Infect Dis. 2020 May 11;221(11):1762-1769
pubmed: 32227123
Gastroenterology. 2015 Oct;149(4):834-8
pubmed: 26291901
Cytometry A. 2020 Apr;97(4):340-343
pubmed: 32187834
Intensive Care Med. 2020 Jun;46(6):1117-1120
pubmed: 32253448
Cell Host Microbe. 2013 May 15;13(5):509-519
pubmed: 23684303
Clin Chim Acta. 2020 May 13;508:110-114
pubmed: 32405080
Int J Infect Dis. 2020 Jun 1;:
pubmed: 32497811
J Med Virol. 2020 Apr 28;:
pubmed: 32343429
Scand J Prim Health Care. 2002 Mar;20(1):50-6
pubmed: 12086285
Nat Rev Microbiol. 2008 Jul;6(7):541-52
pubmed: 18552864
Int J Infect Dis. 2020 Jun;95:304-307
pubmed: 32344011
Science. 2012 Nov 9;338(6108):768-72
pubmed: 23139325
Annu Rev Immunol. 2007;25:443-72
pubmed: 17243893
Hepatology. 2017 May;65(5):1512-1525
pubmed: 28027576
BMJ. 2003 Jun 21;326(7403):1358-62
pubmed: 12816821
Clin Infect Dis. 2020 Mar 12;:
pubmed: 32161940
Crit Care. 2019 Mar 9;23(1):81
pubmed: 30850005
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Br J Haematol. 2020 May;189(3):428-437
pubmed: 32297671
Intensive Care Med. 2020 Jun;46(6):1099-1102
pubmed: 32291463
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Metabolism. 2020 Jul;108:154260
pubmed: 32418885
Int J Infect Dis. 2005 Nov;9(6):323-30
pubmed: 16095942
J Med Virol. 2020 Mar 17;:
pubmed: 32181903
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Curr Clin Microbiol Rep. 2020 Apr 20;:1-7
pubmed: 32318324
Science. 2004 Dec 17;306(5704):2090-3
pubmed: 15514116
Chest. 1995 Jun;107(6):1681-5
pubmed: 7781367
Dalton Trans. 2007 Aug 14;(30):3214-20
pubmed: 17893764
J Intensive Care. 2020 May 24;8:36
pubmed: 32483488
Blood. 1997 Feb 1;89(3):1052-7
pubmed: 9028338
Clin Infect Dis. 2004 Oct 1;39(7):1071-5
pubmed: 15472864
N Engl J Med. 2019 Sep 19;381(12):1148-1157
pubmed: 31532961