CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma.
Animals
Carcinoma, Pancreatic Ductal
/ genetics
Cell Differentiation
/ genetics
Cell Movement
Chemokine CXCL12
/ metabolism
Epithelial Cells
/ pathology
Epithelial-Mesenchymal Transition
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms, Experimental
/ pathology
Mice, Inbred C57BL
Mice, Knockout
Myofibroblasts
/ metabolism
Pancreatic Neoplasms
/ genetics
Receptors, CXCR4
/ genetics
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
02
09
2019
revised:
06
02
2020
accepted:
25
06
2020
pubmed:
2
7
2020
medline:
13
2
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) features abundant stromal cells with an excessive extracellular matrix (ECM), termed the desmoplastic reaction. CXCR4 is a cytokine receptor for stromal cell-derived factor-1 (CXCL12) expressed in PDAC, but its roles in PDAC and the characteristic desmoplastic reaction remain unclear. Here, we generated a mouse model of PDAC with conditional knockout of Cxcr4 (KPC-Cxcr4-KO) by crossing Cxcr4 flox mice with Pdx1-Cre;KrasLSL-G12D/+;Trp53LSL-R172H/+ (KPC-Cxcr4-WT) mice to assess the development of pancreatic intraepithelial neoplasia (PanIN) and pancreatic cancers. Tumor cell characteristics of those two types were analyzed
Identifiants
pubmed: 32606001
pii: 0008-5472.CAN-19-2745
doi: 10.1158/0008-5472.CAN-19-2745
doi:
Substances chimiques
CXCR4 protein, human
0
CXCR4 protein, mouse
0
Chemokine CXCL12
0
Cxcl12 protein, mouse
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4058-4070Commentaires et corrections
Type : ErratumIn
Informations de copyright
©2020 American Association for Cancer Research.