Interactions between cannabidiol and Δ
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
06
03
2020
revised:
28
05
2020
accepted:
24
06
2020
pubmed:
2
7
2020
medline:
28
5
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
Extracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet syndrome. These extracts typically contain cannabidiol (CBD), a phytocannabinoid with well-documented anticonvulsant effects, but may also contain Δ Scn1a Administered alone, CBD (100 mg·kg Low doses of Δ
Sections du résumé
BACKGROUND AND PURPOSE
Extracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet syndrome. These extracts typically contain cannabidiol (CBD), a phytocannabinoid with well-documented anticonvulsant effects, but may also contain Δ
EXPERIMENTAL APPROACH
Scn1a
KEY RESULTS
Administered alone, CBD (100 mg·kg
CONCLUSION AND IMPLICATIONS
Low doses of Δ
Identifiants
pubmed: 32608111
doi: 10.1111/bph.15181
pmc: PMC7443476
doi:
Substances chimiques
NAV1.1 Voltage-Gated Sodium Channel
0
Scn1a protein, mouse
0
Cannabidiol
19GBJ60SN5
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4261-4274Subventions
Organisme : Lambert Initiative for Cannabinoid Therapeutics
Organisme : Australian National Health and Medical Research Council (NHMRC)
Informations de copyright
© 2020 The British Pharmacological Society.
Références
PLoS One. 2012;7(4):e35937
pubmed: 22536451
Epileptic Disord. 2020 Jan 1;22(S1):10-15
pubmed: 32053110
Br J Pharmacol. 2019 May;176(10):1506-1523
pubmed: 29457829
Neurosci Biobehav Rev. 2019 Dec;107:696-712
pubmed: 31580839
Psychopharmacology (Berl). 2012 Feb;219(3):859-73
pubmed: 21796370
Genes Brain Behav. 2014 Feb;13(2):163-72
pubmed: 24152123
Pharmacol Biochem Behav. 1982 Apr;16(4):573-8
pubmed: 6280204
Epilepsia. 2019 Nov;60(11):2224-2234
pubmed: 31625159
J Nat Prod. 2019 Nov 22;82(11):3047-3055
pubmed: 31686510
Handb Clin Neurol. 2013;111:627-33
pubmed: 23622210
Seizure. 2016 Feb;35:41-4
pubmed: 26800377
Drug Alcohol Depend. 2008 Apr 1;94(1-3):191-8
pubmed: 18206320
Psychopharmacology (Berl). 2018 Nov;235(11):3289-3302
pubmed: 30238130
Eur Neuropsychopharmacol. 2017 Dec;27(12):1223-1237
pubmed: 29129557
Neuropsychopharmacology. 2018 Jan;43(1):142-154
pubmed: 28875990
Epilepsia. 2011 Apr;52 Suppl 2:3-9
pubmed: 21463272
J Pharmacol Exp Ther. 1980 May;213(2):216-21
pubmed: 6245205
Br J Pharmacol. 2019 Dec;176 Suppl 1:S142-S228
pubmed: 31710715
Psychopharmacology (Berl). 2011 Nov;218(2):443-57
pubmed: 21667074
Ment Health Clin. 2016 Nov 3;6(6):277-284
pubmed: 29955482
Pain. 2017 Dec;158(12):2452-2460
pubmed: 28885457
Drug Alcohol Depend. 2017 Jun 1;175:187-197
pubmed: 28445853
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
Sci Rep. 2017 May 10;7(1):1682
pubmed: 28490751
Br J Pharmacol. 2015 Oct;172(20):4790-805
pubmed: 26218440
Lancet. 2018 Mar 17;391(10125):1085-1096
pubmed: 29395273
Psychopharmacologia. 1974 Jul 11;37(3):255-64
pubmed: 4850601
Sci Rep. 2018 Jul 5;8(1):10154
pubmed: 29977078
J Pharmacol Exp Ther. 1977 Apr;201(1):26-32
pubmed: 850145
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11229-11234
pubmed: 28973916
N Engl J Med. 2018 May 17;378(20):1888-1897
pubmed: 29768152
Eur J Pharmacol. 1976 Jan;35(1):7-16
pubmed: 1253828
Fundam Appl Toxicol. 1996 Mar;30(1):109-17
pubmed: 8812248
Psychopharmacology (Berl). 2006 Jun;186(2):226-34
pubmed: 16572263
Ann Clin Transl Neurol. 2018 Aug 01;5(9):1077-1088
pubmed: 30250864
Eur J Pharmacol. 2001 Sep 28;428(1):51-7
pubmed: 11779037
Br J Pharmacol. 2010 Aug;160(7):1577-9
pubmed: 20649561
N Engl J Med. 2017 May 25;376(21):2011-2020
pubmed: 28538134
Epilepsia. 2011 Apr;52 Suppl 2:24-9
pubmed: 21463275
Epilepsia. 2015 Aug;56(8):1246-51
pubmed: 26114620
Br J Pharmacol. 2020 Sep;177(18):4261-4274
pubmed: 32608111
Neurosci Biobehav Rev. 2017 May;76(Pt B):380-395
pubmed: 27639448
Front Pharmacol. 2019 Mar 20;10:226
pubmed: 30949046
Front Neurol. 2019 Jul 03;10:716
pubmed: 31333569
Drug Metab Rev. 2014 Feb;46(1):86-95
pubmed: 24160757
Psychopharmacology (Berl). 2019 Sep;236(9):2713-2724
pubmed: 31044290
Clin Toxicol (Phila). 2020 Feb;58(2):124-128
pubmed: 31111749
Br J Pharmacol. 2016 Jan;173(1):53-65
pubmed: 26377899
Epilepsy Behav. 2016 Nov;64(Pt A):69-74
pubmed: 27732919
Br J Pharmacol. 2019 Dec;176 Suppl 1:S21-S141
pubmed: 31710717
Ann Clin Transl Neurol. 2017 Apr 26;4(5):326-339
pubmed: 28491900
J Epilepsy Res. 2017 Dec 31;7(2):61-76
pubmed: 29344464