Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on Docetaxel.

Antineoplastic Agents / pharmacology Docetaxel / pharmacology Molecular Docking Simulation Noscapine / pharmacology Tubulin
9-vinyl-phenyl noscapine anti-tumor activity combination drug therapy molecular docking molecular dynamics simulations noscapine noscapinoids tubulin binding affinity

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
09 2021
Historique:
pubmed: 2 7 2020
medline: 25 2 2023
entrez: 2 7 2020
Statut: ppublish

Résumé

Docetaxel (DOX) based combination therapy is a novel therapeutic strategy that attracts great interest in breast cancer treatment but its clinical utility got limited due to side effects. In contrast, noscapine, an antitussive drug showed antitumor activity against many cancers without any side effects that targets microtubules and attenuates its dynamic instability. In the quest for an increase in the anticancer activity of noscapine, we strategically designed a novel derivative, 9-vinyl phenyl noscapine (VPN), based on our

Identifiants

DOI: 10.1080/07391102.2020.1785945 PMID: 32608323
pubmed: 32608323
doi: 10.1080/07391102.2020.1785945
doi:

Substances chimiques

Antineoplastic Agents 0
Tubulin 0
Docetaxel 15H5577CQD
Noscapine 8V32U4AOQU

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5276-5289

Auteurs

Shruti Gamya Dash (SG)

Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Sambalpur, Odisha, India.

Charu Suri (C)

Drug Discovery Research Centre, Translational Health Science and Technology Institute, Pali, Haryana, India.

Praveen Kumar Reddy Nagireddy (PKR)

Fluoro and Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.

Srinivas Kantevari (S)

Fluoro and Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.

Pradeep Kumar Naik (PK)

Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Sambalpur, Odisha, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Rational design of 9-vinyl-phenyl noscapine as...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Docetaxel › Rational design of 9-vinyl-phenyl noscapine as...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Rational design of 9-vinyl-phenyl noscapine as...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Noscapine › Rational design of 9-vinyl-phenyl noscapine as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Rational design of 9-vinyl-phenyl noscapine as...