Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.
AMP-Activated Protein Kinases
/ genetics
Activating Transcription Factor 1
/ genetics
Animals
Cells, Cultured
DNA-Binding Proteins
/ genetics
Disease Models, Animal
Erythrocytes
/ metabolism
Female
Hematoma
/ genetics
Heme Oxygenase-1
/ genetics
Insulin-Like Growth Factor I
/ genetics
Iron
/ metabolism
Lipid Metabolism
Liver X Receptors
/ genetics
Macrophages
/ metabolism
Male
Membrane Proteins
/ genetics
Mice, Inbred C57BL
Mice, Knockout
Oxidative Stress
Time Factors
hemorrhage
inflammation
lipids
macrophages
oxidative stress
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
11 09 2020
11 09 2020
Historique:
pubmed:
3
7
2020
medline:
26
5
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
The efficient resolution of tissue hemorrhage is an important homeostatic function. In human macrophages in vitro, heme activates an AMPK (AMP-activated protein kinase)/ATF1 (activating transcription factor-1) pathway that directs Mhem macrophages through coregulation of HO-1 (heme oxygenase-1; We asked whether this pathway had an in vivo role in mice. Perifemoral hematomas were used as a model of hematoma resolution. In mouse bone marrow-derived macrophages, heme induced HO-1, lipid regulatory genes including LXR (lipid X receptor), the growth factor IGF1 (insulin-like growth factor-1), and the splenic red pulp macrophage gene Taken together, these data demonstrate that both AMPK and ATF1 are required for normal hematoma resolution. Graphic Abstract: An online graphic abstract is available for this article.
Identifiants
pubmed: 32611235
doi: 10.1161/CIRCRESAHA.119.315528
pmc: PMC7478221
doi:
Substances chimiques
Activating Transcription Factor 1
0
Atf1 protein, mouse
0
DNA-Binding Proteins
0
Liver X Receptors
0
Membrane Proteins
0
Spic protein, mouse
0
insulin-like growth factor-1, mouse
0
Insulin-Like Growth Factor I
67763-96-6
Iron
E1UOL152H7
Heme Oxygenase-1
EC 1.14.14.18
Hmox1 protein, mouse
EC 1.14.14.18
Prkab1 protein, mouse
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
928-944Subventions
Organisme : Medical Research Council
ID : MC_U120027537
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L015129/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/71/33242
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104931
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104931/Z/14/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/13/12/30037
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N011775/1
Pays : United Kingdom
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