On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19.


Journal

Journal for immunotherapy of cancer
ISSN: 2051-1426
Titre abrégé: J Immunother Cancer
Pays: England
ID NLM: 101620585

Informations de publication

Date de publication:
07 2020
Historique:
accepted: 12 06 2020
entrez: 3 7 2020
pubmed: 3 7 2020
medline: 21 7 2020
Statut: ppublish

Résumé

The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. In detail, we provide available information on (1) safety regarding the risk of new infections, (2) effects on the outcome of pre-existing infections, (3) whether immunosuppressive drugs used to treat ICI-related adverse events affect the risk of infection or virulence of pre-existing infections, (4) whether the use of vaccines in ICI-treated patients is considered safe, and (5) whether there are beneficial effects of ICIs that even qualify them as a therapeutic approach for these viral infections.

Identifiants

pubmed: 32611687
pii: jitc-2020-001145
doi: 10.1136/jitc-2020-001145
pmc: PMC7358098
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: TG has received speakers and/or advisory board honoraria from BMS, Sanofi-Genzyme, MSD, Novartis Pharma, Roche, Abbvie, Almirall, Janssen, Lilly, Pfizer, Pierre Fabre, Merck-Serono, outside the submitted work. JR and CHS declare that they have no competing interests. JCB is receiving speaker’s bureau honoraria from Amgen, Pfizer, Merck-Serono, Recordati and Sanofi, is a paid consultant/advisory board member for Boehringer Ingelheim, eTheRNA, In ProTher, MerckSerono, Pfizer, 4SC and Sanofi. His group receives research grants from Bristol-Myers Squibb, Merck Serono, HTG, IQVIA, and Alcedis.

Références

Lancet. 2017 Jun 24;389(10088):2492-2502
pubmed: 28434648
AIDS. 2018 Jul 17;32(11):1491-1497
pubmed: 29746296
JAMA Netw Open. 2019 Nov 1;2(11):e1914816
pubmed: 31702796
J Clin Oncol. 2017 Nov 20;35(33):3774-3780
pubmed: 28968173
J Immunother Cancer. 2019 Feb 22;7(1):53
pubmed: 30795818
Immunotherapy. 2020 Apr;12(6):351-354
pubmed: 32290754
J Immunol. 2009 Jan 15;182(2):980-7
pubmed: 19124741
Thorac Cancer. 2020 Mar;11(3):799-804
pubmed: 32017466
J Clin Neuromuscul Dis. 2019 Jun;20(4):194-199
pubmed: 31135622
Annu Rev Med. 2018 Jan 29;69:301-318
pubmed: 29414259
Open Forum Infect Dis. 2019 Sep 30;6(10):ofz374
pubmed: 31660340
Exp Mol Med. 2018 Dec 13;50(12):1-11
pubmed: 30546008
Future Oncol. 2020 Jun;16(17):1153-1156
pubmed: 32323577
J Eur Acad Dermatol Venereol. 2020 Jul;34(7):1395-1396
pubmed: 32426877
Int J Infect Dis. 2017 Mar;56:221-228
pubmed: 28163164
J Neurovirol. 2019 Apr;25(2):284-287
pubmed: 30864100
JAMA Oncol. 2019 Jul 1;5(7):1049-1054
pubmed: 30730549
N Engl J Med. 2019 Apr 25;380(17):1597-1605
pubmed: 30969503
PLoS One. 2018 Jun 7;13(6):e0198158
pubmed: 29879143
Degener Neurol Neuromuscul Dis. 2019 Dec 02;9:109-121
pubmed: 31819703
J Infect Dis. 2017 Jun 1;215(11):1725-1733
pubmed: 28431010
Clin Infect Dis. 2020 Jul 11;71(2):422-425
pubmed: 31680143
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Allergy Clin Immunol. 2020 Jul;146(1):110-118
pubmed: 32294485
Clin Infect Dis. 2020 Mar 17;70(7):1519
pubmed: 31210266
J Hepatol. 2019 Nov;71(5):900-907
pubmed: 31306680
BMJ. 2020 Mar 26;368:m1198
pubmed: 32217618
J Autoimmun. 2020 May;109:102442
pubmed: 32253068
J Acquir Immune Defic Syndr. 2012 Jul 1;60(3):244-8
pubmed: 22549384
J Viral Hepat. 2020 Apr 27;:
pubmed: 32340080
Lancet Neurol. 2010 Apr;9(4):425-37
pubmed: 20298966
J Immunother Cancer. 2020 Apr;8(1):
pubmed: 32300051
Curr Opin HIV AIDS. 2019 Mar;14(2):121-128
pubmed: 30585798
Bioinformation. 2020 Mar 31;16(3):219-222
pubmed: 32308263
AIDS. 2007 Oct 1;21(15):2005-13
pubmed: 17885290
Immunotherapy. 2019 Apr;11(5):429-441
pubmed: 30698054
Nat Med. 2009 Aug;15(8):893-900
pubmed: 19543283
Int J Infect Dis. 2020 May;94:74-77
pubmed: 32229257
Cancer Discov. 2020 May 12;:
pubmed: 32398243
Immunotherapy. 2020 Jun;12(8):545-548
pubmed: 32349579
Nature. 2016 Nov 3;539(7627):102-106
pubmed: 27749818
J Thorac Oncol. 2020 Jun;15(6):e83-e85
pubmed: 32243919
Cell Rep Med. 2020 May 19;1(2):100016
pubmed: 32562483
N Engl J Med. 2019 Apr 25;380(17):1667-1668
pubmed: 30969502
PLoS Pathog. 2012;8(5):e1002710
pubmed: 22615569
Medicine (Baltimore). 2020 Jan;99(5):e19013
pubmed: 32000444
Asia Pac J Clin Oncol. 2020 Aug;16(4):201-210
pubmed: 32212243
Mol Cancer. 2019 Nov 6;18(1):155
pubmed: 31690319
J Thorac Oncol. 2018 Dec;13(12):1930-1939
pubmed: 30267842
Cancer. 2017 Jun 1;123(11):1904-1911
pubmed: 28241095
Pediatr Blood Cancer. 2017 Dec;64(12):
pubmed: 28544595
J Oncol Pharm Pract. 2020 Apr;26(3):647-654
pubmed: 31474214
Immunotherapy. 2020 Apr;12(5):269-273
pubmed: 32212881
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
ESMO Open. 2017 Jul 3;2(2):e000213
pubmed: 28761757
Hum Vaccin Immunother. 2016 Sep;12(9):2351-6
pubmed: 27269431
Nat Rev Immunol. 2018 Feb;18(2):91-104
pubmed: 28990586
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Eur J Immunol. 2017 May;47(5):765-779
pubmed: 28393361
Cancers (Basel). 2020 Mar 20;12(3):
pubmed: 32245016
J Immunother Cancer. 2019 Dec 17;7(1):353
pubmed: 31847881
Cancer Treat Rev. 2020 Jun;86:102011
pubmed: 32213376
J Infect Dis. 1997 Jul;176(1):250-4
pubmed: 9207375
Oncologist. 2020 Feb;25(2):105-111
pubmed: 32043797
Clin Cancer Res. 2020 Jan 1;26(1):232-241
pubmed: 31624103
Virol Sin. 2018 Dec;33(6):467-471
pubmed: 30570713
PLoS One. 2013 May 22;8(5):e63818
pubmed: 23717490
PLoS Pathog. 2014 Jan;10(1):e1003856
pubmed: 24391505
J Transl Autoimmun. 2020 Apr 9;:100051
pubmed: 32292901
Retrovirology. 2015 Feb 08;12:14
pubmed: 25756928
Crit Rev Oncol Hematol. 2019 Jul;139:87-90
pubmed: 31112887
Emerg Infect Dis. 2019 Nov;25(11):2145-2147
pubmed: 31625858
Eur J Cancer. 2018 Nov;104:182-187
pubmed: 30368069
Ann Oncol. 2017 Oct 1;28(10):2377-2385
pubmed: 28945858
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32353870
J Immunother Cancer. 2018 May 22;6(1):40
pubmed: 29789020
PLoS Pathog. 2016 Jul 14;12(7):e1005661
pubmed: 27415828
Clin Infect Dis. 2020 Jan 2;70(2):193-199
pubmed: 30874791
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Immunotherapy. 2018 Oct;10(14):1229-1239
pubmed: 30326787
PLoS Pathog. 2010 Jun 10;6(6):e1000947
pubmed: 20548953
JCO Oncol Pract. 2020 Jul;16(7):e573-e580
pubmed: 32048920
Lung Cancer. 2020 Jul;145:181-185
pubmed: 32423643
Genome Med. 2018 Sep 20;10(1):71
pubmed: 30236153
Chin Med J (Engl). 2020 May 5;133(9):1080-1086
pubmed: 32149773
Nat Immunol. 2007 Nov;8(11):1246-54
pubmed: 17906628
Front Immunol. 2020 Mar 04;11:401
pubmed: 32194573
Dig Dis. 2017;35(4):334-338
pubmed: 28468011
Clin Microbiol Infect. 2018 Jun;24 Suppl 2:S95-S107
pubmed: 29427804

Auteurs

Thilo Gambichler (T)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany t.gambichler@klinikum-bochum.de.

Judith Reuther (J)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany t.gambichler@klinikum-bochum.de.

Christina H Scheel (CH)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany t.gambichler@klinikum-bochum.de.
Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany

Jürgen Christian Becker (JC)

Translational Skin Cancer Research, German Cancer Consortium (DKTK), Dermatology, University Duisburg-Essen, Essen, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH