Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.
70-kilodalton heat shock protein (Hsp70)
AARS1
METTL21C
alanine tRNA synthetase
aminoacyl-tRNA synthetase
lysine methylation
methyltransferase-like 21C (METTL21C)
posttranslational modification
protein methylation
signal transduction
skeletal muscle
subcellular fractionation
substrate specificity
valosin-containing protein (VCP/p97)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
22
05
2020
revised:
26
06
2020
pubmed:
3
7
2020
medline:
23
1
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Protein-lysine methylation is a common posttranslational modification (PTM) throughout the human proteome that plays important roles in diverse biological processes. In humans, there are >100 known and candidate protein lysine methyltransferases (PKMTs), many of which are linked to human diseases. Methyltransferase-like protein 21C (METTL21C) is a PKMT implicated in muscle biology that has been reported to methylate valosin-containing protein/p97 (VCP) and heat shock 70-kDa protein 8 (HSPA8). However, a clear
Identifiants
pubmed: 32611769
pii: S0021-9258(17)48478-X
doi: 10.1074/jbc.RA120.014505
pmc: PMC7450112
doi:
Substances chimiques
METTL21C protein, mouse
EC 2.1.1.-
Methyltransferases
EC 2.1.1.-
Lysine
K3Z4F929H6
Banques de données
PDB
['4MTL']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11822-11832Subventions
Organisme : NCI NIH HHS
ID : R01 CA236118
Pays : United States
Informations de copyright
© 2020 Zoabi et al.
Déclaration de conflit d'intérêts
Conflict of interest—O. G. is a co-founder of EpiCypher, Inc. and Athelas Therapeutics, Inc.
Références
Nat Rev Mol Cell Biol. 2015 Sep;16(9):519-32
pubmed: 26296162
J Bone Miner Res. 2014 Jul;29(7):1531-1540
pubmed: 24677265
J Biol Chem. 2013 Sep 27;288(39):27752-63
pubmed: 23921388
Nat Protoc. 2007;2(4):933-8
pubmed: 17446892
Mol Cell. 2004 Mar 26;13(6):829-41
pubmed: 15053876
Methods Mol Biol. 2014;1188:207-26
pubmed: 25059614
Nat Immunol. 2011 Jan;12(1):29-36
pubmed: 21131967
Nucleic Acids Res. 2017 May 5;45(8):4370-4389
pubmed: 28108655
Nat Rev Mol Cell Biol. 2015 Aug;16(8):499-513
pubmed: 26204160
Nat Commun. 2012;3:1038
pubmed: 22948820
Cell. 2019 Jan 24;176(3):491-504.e21
pubmed: 30612740
Nature. 2014 Jun 12;510(7504):283-7
pubmed: 24847881
J Biol Chem. 2019 Sep 13;294(37):13718-13728
pubmed: 31346037
Biochem J. 2016 Jul 15;473(14):1995-2009
pubmed: 27407169
J Exp Bot. 2018 Aug 31;69(19):4569-4581
pubmed: 29931361
Nat Rev Mol Cell Biol. 2019 Oct;20(10):573-589
pubmed: 31270442
J Biol Chem. 2010 Jan 29;285(5):3341-50
pubmed: 19940157
Biochim Biophys Acta. 2014 Dec;1839(12):1395-403
pubmed: 24561874
RNA. 2014 Jun;20(6):758-64
pubmed: 24751649
J Biol Chem. 2017 Nov 17;292(46):18878-18885
pubmed: 28912266
J Biol Chem. 2017 Oct 27;292(43):17950-17962
pubmed: 28887308
Cold Spring Harb Perspect Med. 2016 Nov 1;6(11):
pubmed: 27580749
Mol Cell. 2019 Sep 19;75(6):1092-1101
pubmed: 31539507
Meat Sci. 2019 Jul;153:117-125
pubmed: 30927683
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Nat Rev Mol Cell Biol. 2015 Jan;16(1):5-17
pubmed: 25491103
Nat Commun. 2018 Aug 24;9(1):3411
pubmed: 30143613
Genes (Basel). 2019 Aug 20;10(8):
pubmed: 31434291
Annu Rev Biochem. 2000;69:617-50
pubmed: 10966471
Trends Biochem Sci. 2018 Mar;43(3):211-223
pubmed: 29398204
J Biol Chem. 2015 May 8;290(19):12040-7
pubmed: 25795785
J Biol Chem. 2019 Aug 2;294(31):11654-11664
pubmed: 31213526
Nature. 2017 Mar 23;543(7646):573-576
pubmed: 28297716
Nature. 2019 Jan;565(7739):372-376
pubmed: 30626964
RNA Biol. 2018 Mar 4;15(3):314-319
pubmed: 29447067
Cell Rep. 2018 May 1;23(5):1342-1356
pubmed: 29719249
Nat Struct Mol Biol. 2019 Oct;26(10):880-889
pubmed: 31582846
Trends Biochem Sci. 2013 May;38(5):243-52
pubmed: 23490039
Nucleic Acids Res. 2017 Aug 21;45(14):8239-8254
pubmed: 28520920