Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.
A549 Cells
Antigens, Neoplasm
/ genetics
DNA Damage
Guanine
/ analogs & derivatives
HMGB1 Protein
/ genetics
Humans
Indium
/ administration & dosage
Lung Neoplasms
/ genetics
Mitogen-Activated Protein Kinases
/ genetics
Mutagens
Nanoparticles
/ administration & dosage
Toll-Like Receptor 9
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
11
12
2019
accepted:
06
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Indium compounds have been widely used in manufacturing displays of mobile phones, computers and televisions. However, inhalation exposure to indium compounds causes interstitial pneumonia in exposed workers and lung cancer in experimental animals. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed under inflammatory conditions and may participate in indium-induced carcinogenesis. In this study, we examined 8-nitroG formation in A549 cultured human lung epithelial cells treated with indium compounds, including nanoparticles of indium oxide (In
Identifiants
pubmed: 32612147
doi: 10.1038/s41598-020-67488-3
pii: 10.1038/s41598-020-67488-3
pmc: PMC7329867
doi:
Substances chimiques
8-nitroguanine
0
Antigens, Neoplasm
0
HMGB1 Protein
0
HMGB1 protein, human
0
Mutagens
0
TLR9 protein, human
0
Toll-Like Receptor 9
0
Indium
045A6V3VFX
Guanine
5Z93L87A1R
MOK protein, human
EC 2.7.11.22
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10741Références
Medvedovski, E., Alvarez, N., Yankov, O. & Olsson, M. K. Advanced indium-tin oxide ceramics for sputtering targets. Ceram. Int. 34, 1173–1182 (2008).
Guo, E. J. et al. Structure and characteristics of ultrathin indium tin oxide films. Appl. Phys. Lett. 98, 011905 (2011).
USGS. Indium statistics. In Historical statistics for mineral and material commodities in the United States (2016 version, last modification: Jan 19, 2017) (eds. Kelly, T.D. & Matos, G.R.) USGS Data Series 140, https://s3-us-west-2.amazonaws.com/prd-wret/assets/palladium/production/mineral-pubs/historical-statistics/ds140-indiu.xlsx (2017).
USGS. Indium. In Mineral Commodity Summaries 2019. 78–79 (USGS, 2019).
Tanaka, A., Hirata, M., Homma, T. & Kiyohara, Y. Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters. J. Occup. Health 52, 14–22 (2010).
pubmed: 19940388
Homma, T., Ueno, T., Sekizawa, K., Tanaka, A. & Hirata, M. Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide. J. Occup. Health 45, 137–139 (2003).
pubmed: 14646287
Chonan, T., Taguchi, O. & Omae, K. Interstitial pulmonary disorders in indium-processing workers. Eur. Respir. J. 29, 317–324 (2007).
pubmed: 17050566
Omae, K. et al. Indium lung-case reports and epidemiology. Int. Arch. Occup. Environ. Health 84, 471–477 (2011).
pubmed: 20886351
Xiao, Y. L., Cai, H. R., Wang, Y. H., Meng, F. Q. & Zhang, D. P. Pulmonary alveolar proteinosis in an indium-processing worker. Chin. Med. J. 123, 1347–1350 (2010).
pubmed: 20529594
Cummings, K. J. et al. Pulmonary alveolar proteinosis in workers at an indium processing facility. Am. J. Respir. Crit. Care Med. 181, 458–464 (2010).
pubmed: 20019344
Cummings, K. J. et al. Indium lung disease. Chest 141, 1512–1521 (2012).
pubmed: 22207675
IARC. Indium phosphide. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide Vol. 86, 197–224 (2006).
Nagano, K. et al. Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice. J. Occup. Health 53, 175–187 (2011).
pubmed: 21471693
IARC. Indium tin oxide. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Welding, molybdenum trioxide, and indium tin oxide Vol. 118, 283–306 (2018).
Hussain, S. P. & Harris, C. C. Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 121, 2373–2380 (2007).
pubmed: 17893866
Hussain, S. P., Hofseth, L. J. & Harris, C. C. Radical causes of cancer. Nat. Rev. Cancer 3, 276–285 (2003).
pubmed: 12671666
Ohshima, H., Tatemichi, M. & Sawa, T. Chemical basis of inflammation-induced carcinogenesis. Arch. Biochem. Biophys. 417, 3–11 (2003).
pubmed: 12921773
Yermilov, V. et al. Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro. Carcinogenesis 16, 2045–2050 (1995).
pubmed: 7554052
Kawanishi, S., Hiraku, Y., Pinlaor, S. & Ma, N. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem. 387, 365–372 (2006).
pubmed: 16606333
Hiraku, Y. Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. Environ. Health Prev. Med. 15, 63–72 (2010).
pubmed: 19921494
Afroz, T. et al. Nitrative DNA damage in cultured macrophages exposed to indium oxide. J. Occup. Health 60, 148–155 (2018).
pubmed: 29187674
Tabei, Y. et al. Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage. J. Biochem. 159, 225–237 (2016).
pubmed: 26378248
Jia, L. et al. Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia. Blood 123, 1709–1719 (2014).
pubmed: 24464016
pmcid: 3954052
Musumeci, D., Roviello, G. N. & Montesarchio, D. An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies. Pharmacol. Ther. 141, 347–357 (2014).
pubmed: 24220159
Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805–820 (2010).
pubmed: 20303872
pmcid: 20303872
Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8, 487–496 (2007).
pubmed: 17417641
Hiraku, Y. et al. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. Part. Fibre Toxicol. 13, 16 (2016).
pubmed: 27026438
pmcid: 4812657
Guo, F. et al. Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells. Toxicol. Appl. Pharmacol. 260, 183–192 (2012).
pubmed: 22373798
Hiraku, Y. et al. Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells. Mutat. Res. 818, 7–16 (2017).
pubmed: 28477879
Gwinn, W. M. et al. Macrophage solubilization and cytotoxicity of indium-containing particles in vitro. Toxicol. Sci. 135, 414–424 (2013).
pubmed: 23872580
pmcid: 3807620
Faller, P., Hureau, C. & Berthoumieu, O. Role of metal ions in the self-assembly of the Alzheimer’s amyloid-β peptide. Inorg. Chem. 52, 12193–12206 (2013).
pubmed: 23607830
Murray, J. R., de la Vega, L., Hayes, J. D., Duan, L. & Penning, T. M. Induction of the antioxidant response by the transcription factor NRF2 increases bioactivation of the mutagenic air pollutant 3-nitrobenzanthrone in human lung cells. Chem. Res. Toxicol. 32, 2538–2551 (2019).
pubmed: 31746589
Zhang, X. et al. New insights into the Nrf-2/HO-1 signaling axis and its application in pediatric respiratory diseases. Oxid. Med. Cell. Longev. 2019, 3214196 (2019).
pubmed: 31827672
pmcid: 6885770
Iwasawa, S. et al. Personal indium exposure concentration in respirable dusts and serum indium level. Ind. Health 55, 87–90 (2017).
pubmed: 27644848
ICRP. Human Respiratory Tract Model for Radiological Protection. A Report of a Task Group of the International Commission on Radiological Protection (ICRP Publication 66). (Pergamon, 1994).
Kundu, J. K. & Surh, Y. J. Inflammation: Gearing the journey to cancer. Mutat. Res. 659, 15–30 (2008).
pubmed: 18485806
Karin, M. & Greten, F. R. NF-κB: Linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749–759 (2005).
pubmed: 16175180
Gratton, S. E. et al. The effect of particle design on cellular internalization pathways. Proc. Natl. Acad. Sci. USA 105, 11613–11618 (2008).
pubmed: 18697944
Rejman, J., Oberle, V., Zuhorn, I. S. & Hoekstra, D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377, 159–169 (2004).
pubmed: 14505488
pmcid: 1223843
Kawanishi, S. & Hiraku, Y. Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation. Antioxid. Redox Signal. 8, 1047–1058 (2006).
pubmed: 16771694
Hiraku, Y. et al. Formation of the nitrative DNA lesion 8-nitroguanine is associated with asbestos contents in human lung tissues: A pilot study. J. Occup. Health 56, 186–196 (2014).
pubmed: 24598051
Yermilov, V., Rubio, J. & Ohshima, H. Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Lett. 376, 207–210 (1995).
pubmed: 7498543
Loeb, L. A. & Preston, B. D. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet. 20, 201–230 (1986).
pubmed: 3545059
Suzuki, N., Yasui, M., Geacintov, N. E., Shafirovich, V. & Shibutani, S. Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine. Biochemistry 44, 9238–9245 (2005).
pubmed: 15966748
Badding, M. A. et al. Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation. PLoS ONE 10, e0124368 (2015).
pubmed: 25874458
pmcid: 4395338
Nakae, Y., Stoward, P. J., Bespalov, I. A., Melamede, R. J. & Wallace, S. S. A new technique for the quantitative assessment of 8-oxoguanine in nuclear DNA as a marker of oxidative stress. Application to dystrophin-deficient DMD skeletal muscles. Histochem. Cell Biol. 124, 335–345 (2005).
pubmed: 16091938
Pinlaor, S. et al. Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: A model of inflammation-mediated carcinogenesis. Nitric Oxide 11, 175–183 (2004).
pubmed: 15491850
Hiraku, Y. & Kawanishi, S. Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis. In Methods in Molecular Biology Vol. 512 (ed. Walker, J. M.) 3–13 (Springer, Berlin, 2009).