Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
AMP-Activated Protein Kinases
/ metabolism
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Animals
Cholestasis
/ complications
Cyclic AMP Response Element-Binding Protein
/ metabolism
Fatty Liver
/ complications
Female
Hep G2 Cells
Humans
Lipid Metabolism
Male
Mice, Inbred BALB C
Mice, Knockout
Perilipin-2
/ metabolism
Triglycerides
/ metabolism
ATP-Binding Cassette Sub-Family B Member 4
Journal
Laboratory investigation; a journal of technical methods and pathology
ISSN: 1530-0307
Titre abrégé: Lab Invest
Pays: United States
ID NLM: 0376617
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
27
02
2020
accepted:
03
06
2020
revised:
03
06
2020
pubmed:
3
7
2020
medline:
3
2
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Clinical studies demonstrated that nonalcoholic steatohepatitis is associated with liver-related outcomes in chronic hepatitis B. Furthermore, primary biliary fibrosis and biliary atresia occurred in patients with HBV infection. Interestingly, hepatitis B virus surface protein (HBs) transgenic mice spontaneously develop hepatic steatosis. Our aim is to investigate the effect of Abcb4 knockout-induced cholestasis on liver steatosis in HBs transgenic mice. Hybrids of HBs transgenic and Abcb4
Identifiants
pubmed: 32612285
doi: 10.1038/s41374-020-0457-9
pii: S0023-6837(22)00341-5
pmc: PMC7572243
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
Cyclic AMP Response Element-Binding Protein
0
Perilipin-2
0
Plin2 protein, mouse
0
Triglycerides
0
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1411-1424Références
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