Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly.
Brain
/ growth & development
Brazil
Cell Cycle Proteins
/ genetics
Child, Preschool
Cytoskeletal Proteins
/ genetics
DNA Methylation
Female
Humans
Immunity
/ genetics
Infant
Male
Microcephaly
/ virology
Neurogenesis
/ genetics
Pregnancy
Pregnancy Complications, Infectious
/ virology
Zika Virus
/ immunology
Zika Virus Infection
Zika virus
epigenome-wide association study
methylation
microcephaly
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
13 02 2021
13 02 2021
Historique:
received:
27
03
2020
accepted:
25
06
2020
pubmed:
3
7
2020
medline:
1
10
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.
Identifiants
pubmed: 32614431
pii: 5866531
doi: 10.1093/infdis/jiaa383
doi:
Substances chimiques
Cell Cycle Proteins
0
Cytoskeletal Proteins
0
MCPH1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
435-440Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.