Genetic impact of CDHR3 on the adult onset of asthma and COPD.
Adult
Age of Onset
Aged
Aged, 80 and over
Asthma
/ diagnosis
Cadherin Related Proteins
Cadherins
/ genetics
Enterovirus
/ pathogenicity
Enterovirus Infections
/ diagnosis
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Japan
/ epidemiology
Longitudinal Studies
Male
Membrane Proteins
/ genetics
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Pulmonary Disease, Chronic Obstructive
/ diagnosis
Retrospective Studies
Risk Assessment
Risk Factors
adult-onset asthma
atopy
cadherin-related family member 3 (CDHR3)
chronic obstructive pulmonary disease (COPD)
genetics
rhinovirus
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
17
03
2020
revised:
11
06
2020
accepted:
14
06
2020
pubmed:
3
7
2020
medline:
3
11
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Adult-onset asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases caused by complex gene-environment interactions. A functional single nucleotide polymorphism of cadherin-related family member 3 (CDHR3), known as a receptor of rhinovirus-C, is associated with childhood-onset asthma especially in atopic individuals. Here, we identified risk factors for adult-onset asthma and COPD, focusing on the impact of the CDHR3 variant in atopic individuals. We conducted a longitudinal, retrospective, observational cohort study of 1523 healthy adults with baseline examinations at Tsukuba Medical Center Hospital in 2008 and retrospectively identified new-onset, physician-diagnosed asthma or COPD from 2009 to 2018. We assessed risk factors by the Cox regression analysis. The impact of CDHR3 variant rs6967330 was also examined in individuals with pre-existing atopy. Over 10 study years, 103 people developed airway diseases (79 asthma and 24 COPD; 52 females, average onset-age 55 years old, range 38-80). Higher body mass index (BMI) and lower forced expiratory volume in one second/forced vital capacity (FEV Genetic susceptibility to rhinovirus-C infection in atopic individuals is a risk factor for chronic airway diseases even in later life.
Sections du résumé
BACKGROUND
Adult-onset asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases caused by complex gene-environment interactions. A functional single nucleotide polymorphism of cadherin-related family member 3 (CDHR3), known as a receptor of rhinovirus-C, is associated with childhood-onset asthma especially in atopic individuals.
OBJECTIVE
Here, we identified risk factors for adult-onset asthma and COPD, focusing on the impact of the CDHR3 variant in atopic individuals.
METHODS
We conducted a longitudinal, retrospective, observational cohort study of 1523 healthy adults with baseline examinations at Tsukuba Medical Center Hospital in 2008 and retrospectively identified new-onset, physician-diagnosed asthma or COPD from 2009 to 2018. We assessed risk factors by the Cox regression analysis. The impact of CDHR3 variant rs6967330 was also examined in individuals with pre-existing atopy.
RESULTS
Over 10 study years, 103 people developed airway diseases (79 asthma and 24 COPD; 52 females, average onset-age 55 years old, range 38-80). Higher body mass index (BMI) and lower forced expiratory volume in one second/forced vital capacity (FEV
CONCLUSION AND CLINICAL RELEVANCE
Genetic susceptibility to rhinovirus-C infection in atopic individuals is a risk factor for chronic airway diseases even in later life.
Substances chimiques
CDHR3 protein, human
0
Cadherin Related Proteins
0
Cadherins
0
Membrane Proteins
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1223-1229Informations de copyright
© 2020 John Wiley & Sons Ltd.
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