Characterization of PCSK9 in the Blood and Skin of Psoriasis.
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
02
2020
revised:
11
05
2020
accepted:
18
05
2020
pubmed:
3
7
2020
medline:
14
9
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Mechanisms explaining the link between psoriasis, a proinflammatory condition, and cardiovascular disease are not fully known. PCSK9 is predominantly expressed in hepatocytes as a critical regulator of lipid metabolism, and clinical trials targeting PCSK9 reduce cardiovascular disease. Independent of its role in lipid metabolism, PCSK9 levels associate with endothelial dysfunction and predict cardiovascular events. We used two separate human psoriasis cohorts and the K14-Rac1V12
Identifiants
pubmed: 32615123
pii: S0022-202X(20)31735-8
doi: 10.1016/j.jid.2020.05.115
pmc: PMC8493651
mid: NIHMS1608246
pii:
doi:
Substances chimiques
PCSK9 protein, human
EC 3.4.21.-
Proprotein Convertase 9
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
308-315Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114978
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL098129
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006252
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006168
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL144993
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006235
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006193
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001447
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139909
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001446
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
N Engl J Med. 2009 Jul 30;361(5):496-509
pubmed: 19641206
J Appl Physiol (1985). 2007 Nov;103(5):1873-8
pubmed: 17717122
Trends Biochem Sci. 2007 Feb;32(2):71-7
pubmed: 17215125
Circ Res. 2018 May 11;122(10):1420-1438
pubmed: 29748367
JAMA. 2006 Oct 11;296(14):1735-41
pubmed: 17032986
J Invest Dermatol. 2019 Apr;139(4):859-867
pubmed: 30395847
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Am Heart Assoc. 2018 Oct 2;7(19):e009996
pubmed: 30371326
Circ Res. 2016 Nov 11;119(11):1242-1253
pubmed: 27654120
Nat Rev Dis Primers. 2016 Nov 24;2:16082
pubmed: 27883001
Circ Res. 2014 Mar 14;114(6):1022-36
pubmed: 24625727
Infect Immun. 2020 Feb 20;88(3):
pubmed: 31843964
JAMA Dermatol. 2016 Nov 1;152(11):1244-1253
pubmed: 27556410
Int J Womens Dermatol. 2019 May 18;5(4):251-255
pubmed: 31700981
Circulation. 2018 Feb 13;137(7):680-683
pubmed: 29440196
Atherosclerosis. 2017 Jul;262:113-122
pubmed: 28535426
J Clin Invest. 2016 Jul 1;126(7):2661-77
pubmed: 27294528
Clin Transl Immunology. 2019 Dec 12;8(12):e01093
pubmed: 31921420
Genome Biol. 2010;11(10):R106
pubmed: 20979621
Circulation. 2016 Mar 29;133(13):1230-9
pubmed: 26896437
JCI Insight. 2018 Jan 11;3(1):
pubmed: 29321372
J Am Coll Cardiol. 2018 Jul 17;72(3):314-329
pubmed: 30012326
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):787-798
pubmed: 30760013
J Invest Dermatol. 2018 Feb;138(2):273-281
pubmed: 28927890
J Biol Chem. 2016 Feb 12;291(7):3508-19
pubmed: 26668321
Circ Res. 2016 Feb 19;118(4):620-36
pubmed: 26892962
Sci Rep. 2018 Feb 2;8(1):2267
pubmed: 29396513
Open Heart. 2018 Sep 18;5(2):e000765
pubmed: 30258647