Altered response to repetitive transcranial magnetic stimulation in patients with chronic primary insomnia.

Electromyography Evoked Potentials, Motor Humans Motor Cortex Sleep Initiation and Maintenance Disorders / therapy Transcranial Magnetic Stimulation
GABA Motor evoked potentials Primary insomnia Repetitive transcranial magnetic stimulation

Journal

Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759

Informations de publication

Date de publication:
08 2020
Historique:
received: 04 02 2020
revised: 17 03 2020
accepted: 26 03 2020
pubmed: 3 7 2020
medline: 22 6 2021
entrez: 3 7 2020
Statut: ppublish

Résumé

We aimed at evaluating the amplitude changes of the motor evoked potentials (MEPs) induced by of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) in10 patients with primary insomnia (PI) and in 10 age-matched healthy controls. Median peak-to-peak MEP amplitudes were assessed in all subjects at three times: at baseline (T Resting motor threshold (RMT) and MEPs amplitude did not differ between the two groups at T The lack of MEP inhibition reflects an altered response to LF rTMS in patients with PI. These rTMS findings are indicative of an altered cortical plasticity in inhibitory circuits within M1 in PI. Subjects with PI exhibited an impairment of the LTD-like mechanisms induced by inhibitory rTMS, thus providing further support to the involvement of GABA neurotransmission in the pathophysiology of PI.

Sections du résumé

BACKGROUND
We aimed at evaluating the amplitude changes of the motor evoked potentials (MEPs) induced by of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) in10 patients with primary insomnia (PI) and in 10 age-matched healthy controls.
METHODS
Median peak-to-peak MEP amplitudes were assessed in all subjects at three times: at baseline (T
RESULTS
Resting motor threshold (RMT) and MEPs amplitude did not differ between the two groups at T
CONCLUSIONS
The lack of MEP inhibition reflects an altered response to LF rTMS in patients with PI. These rTMS findings are indicative of an altered cortical plasticity in inhibitory circuits within M1 in PI. Subjects with PI exhibited an impairment of the LTD-like mechanisms induced by inhibitory rTMS, thus providing further support to the involvement of GABA neurotransmission in the pathophysiology of PI.

Identifiants

DOI: 10.1016/j.sleep.2020.03.030 PMID: 32615461
pubmed: 32615461
pii: S1389-9457(20)30151-9
doi: 10.1016/j.sleep.2020.03.030
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-129

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Raffaele Nardone (R)

Department of Neurology, Franz Tappeiner Hospital, Merano, Italy; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, Salzburg, Austria. Electronic address: raffaele.nardone@asbmeran-o.it.

Stefan Golaszewski (S)

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, Salzburg, Austria.

Vanessa Frey (V)

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.

Francesco Brigo (F)

Department of Neurology, Franz Tappeiner Hospital, Merano, Italy; Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Italy.

Viviana Versace (V)

Department of Neurorehabilitation, Hospital of Vipiteno, Italy; Research Department for Neurorehabilitation South Tyrol, Bolzano, Italy.

Luca Sebastianelli (L)

Department of Neurorehabilitation, Hospital of Vipiteno, Italy; Research Department for Neurorehabilitation South Tyrol, Bolzano, Italy.

Leopold Saltuari (L)

Department of Neurorehabilitation, Hospital of Vipiteno, Italy; Research Department for Neurorehabilitation South Tyrol, Bolzano, Italy; Department of Neurology, Hochzirl Hospital, Zirl, Austria.

Yvonne Höller (Y)

Department of Psychology, University of Akureyri, Iceland.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Myographie › Électromyographie › Altered response to repetitive transcranial...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Excitabilité corticale › Potentiels évoqués › Potentiels évoqués moteurs › Altered response to repetitive transcranial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Altered response to repetitive transcranial...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › Altered response to repetitive transcranial...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles de l'endormissement et du maintien du sommeil › Altered response to repetitive transcranial...
questionsmedicales.fr › Thérapeutique › Magnétothérapie › Stimulation magnétique transcrânienne › Altered response to repetitive transcranial...