Systemic lupus erythematosus and neutropaenia: a hallmark of haematological manifestations.
Adult
Antibodies, Antinuclear
/ blood
Autoimmune Diseases
/ complications
Case-Control Studies
Complement C3
/ immunology
Cross-Sectional Studies
Female
France
/ ethnology
Germany
/ ethnology
Humans
Lupus Erythematosus, Systemic
/ blood
Lymphopenia
/ epidemiology
Male
Neutropenia
/ diagnosis
Sjogren's Syndrome
/ blood
Thrombocytopenia
/ epidemiology
autoantibodies
autoimmune diseases
lupus erythematosus, systemic
Journal
Lupus science & medicine
ISSN: 2053-8790
Titre abrégé: Lupus Sci Med
Pays: England
ID NLM: 101633705
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
23
03
2020
revised:
03
06
2020
accepted:
04
06
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
11
5
2021
Statut:
ppublish
Résumé
Systemic lupus is a chronic autoimmune disease characterised by its phenotypic heterogeneity. Neutropaenia is a frequent event in SLE occurring in 20%-40% of patients depending on the threshold value of neutrophil count. On a daily basis, the management of neutropaenia in SLE is difficult with several possible causes. Moreover, the infectious consequences of neutropaenia in SLE remain not well defined. 998 patients from the Lupus BioBank of the upper Rhein (LBBR), a large German and French cohort of patients with SLE, mostly of Caucasian origin (83%), were included in this study. Neutropaenia was considered when neutrophil count was below 1800×10 208 patients with neutropaenia (21%) were compared with 779 SLE patients without neutropaenia. Neutropaenia in SLE was significantly associated with thrombocytopaenia (OR 4.11 (2.57-10.3)), lymphopaenia (OR 4.41 (2.51-11.5)) and low C3 (OR 1.91 (1.03-4.37)) in multivariate analysis. 65 representative patients with neutropaenia were analysed. Neutropaenia was moderate to severe in 38%, chronic in 31%, and both severe and chronic in 23% of cases. Moderate to severe and chronic neutropaenia were both associated with lymphopaenia and thrombopaenia. Chronic neutropaenia was also associated anti-Ro/SSA antibodies and moderate to severe neutropaenia with oral ulcers. This study is to date the largest cohort to describe neutropaenia in SLE. Neutropaenia displays a strong association with other cytopaenias, suggesting a common mechanism. Chronic neutropaenia is associated with anti-Ro/SSA antibodies with or without identified Sjögren's disease.
Identifiants
pubmed: 32616563
pii: 7/1/e000399
doi: 10.1136/lupus-2020-000399
pmc: PMC7333801
pii:
doi:
Substances chimiques
Antibodies, Antinuclear
0
Complement C3
0
SS-A antibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Z Amoura
(Z)
L Arnaud
(L)
G Blaison
(G)
B Bonnotte
(B)
E Chatelus
(E)
E Ciobanu
(E)
F Duchene
(F)
J P Faller
(JP)
A Gorse
(A)
J E Gottenberg
(JE)
O Hinschberger
(O)
F Jaeger
(F)
P Kieffer
(P)
M Kilifa
(M)
N Magy-Bertrand
(N)
T Martin
(T)
L Martzolff
(L)
F Maurier
(F)
A Meyer
(A)
J-L Pasquali
(JL)
J-L Pennaforte
(JL)
V Poindron
(V)
S Revuz
(S)
M Samson
(M)
J Sibilia
(J)
C Sordet
(C)
A Theulin
(A)
D Wahl
(D)
J C Weber
(JC)
M Bartsch
(M)
N Bartholomä
(N)
C Fiehn
(C)
S Finzel
(S)
A Funkert
(A)
M Hausberg
(M)
H Lorenz
(H)
R Max
(R)
H-H Peter
(HH)
M Rizzi
(M)
A Schwarting
(A)
J Thiel
(J)
N Venhoff
(N)
R Voll
(R)
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Medicine (Baltimore). 2004 Jan;83(1):1-17
pubmed: 14747764
Blood Rev. 2019 Sep;37:100586
pubmed: 31255364
Hematology. 2007 Jun;12(3):257-61
pubmed: 17558704
Ann Rheum Dis. 2014 Dec;73(12):2199-207
pubmed: 24013727
Arthritis Rheum. 1978 Apr;21(3):295-305
pubmed: 646828
Lupus. 2017 May;26(6):640-645
pubmed: 27760809
Arthritis Rheum. 2001 Oct;44(10):2350-7
pubmed: 11665976
Ann N Y Acad Sci. 2009 Sep;1173:103-7
pubmed: 19758138
Lupus. 1997;6(3):248-53
pubmed: 9104731
Cell. 2016 Apr 21;165(3):551-65
pubmed: 27040498
Semin Arthritis Rheum. 2015 Oct;45(2):190-4
pubmed: 26170228
Medicine (Baltimore). 1993 Mar;72(2):113-24
pubmed: 8479324
Clin Exp Immunol. 2000 Apr;120(1):209-17
pubmed: 10759785
Q J Med. 1991 Jul;80(291):605-12
pubmed: 1946940
J Exp Med. 2003 Mar 17;197(6):711-23
pubmed: 12642603