Activity of vitamin D receptor agonists against dengue virus.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
received:
25
02
2020
accepted:
11
05
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
16
12
2020
Statut:
epublish
Résumé
Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to bacterial and viral pathogens. In this study a number of fused bicyclic derivatives of 1H-pyrrolo[1,2]imidazol-1-one with vitamin D receptor (VDR) agonist activity were evaluated for possible anti-DENV activity. The results showed that five of the compounds were able to significantly inhibit DENV infection. The most effective compound, ZD-3, had an EC
Identifiants
pubmed: 32616772
doi: 10.1038/s41598-020-67783-z
pii: 10.1038/s41598-020-67783-z
pmc: PMC7331731
doi:
Substances chimiques
Imidazoles
0
Immunosuppressive Agents
0
Receptors, Calcitriol
0
VDR protein, human
0
Calcitriol
FXC9231JVH
seocalcitol
Q0OZ0D9223
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10835Références
Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504–507. https://doi.org/10.1038/nature12060 (2013).
doi: 10.1038/nature12060
pubmed: 23563266
pmcid: 3651993
Guzman, M. G. & Harris, E. Dengue. Lancet 385, 453–465. https://doi.org/10.1016/S0140-6736(14)60572-9 (2015).
doi: 10.1016/S0140-6736(14)60572-9
pubmed: 25230594
Gubler, D. J. Dengue and dengue hemorrhagic fever. Clin. Microbiol. Rev. 11, 480–496 (1998).
doi: 10.1128/CMR.11.3.480
Fatima, K. & Syed, N. I. Dengvaxia controversy: Impact on vaccine hesitancy. J. Glob. Health 8, 010312–010312. https://doi.org/10.7189/jogh.08-020312 (2018).
doi: 10.7189/jogh.08-020312
pubmed: 30410732
Halstead, S. B. Dengvaxia sensitizes seronegatives to vaccine enhanced disease regardless of age. Vaccine 35, 6355–6358. https://doi.org/10.1016/j.vaccine.2017.09.089 (2017).
doi: 10.1016/j.vaccine.2017.09.089
pubmed: 29029938
Chang, J., Block, T. M. & Guo, J.-T. Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions. Antiviral Res. 99, 251–260. https://doi.org/10.1016/j.antiviral.2013.06.011 (2013).
doi: 10.1016/j.antiviral.2013.06.011
pubmed: 23816430
pmcid: 7114303
Courageot, M.-P., Frenkiel, M.-P., Dos Santos, C. D., Deubel, V. & Desprès, P. α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. J. Virol. 74, 564–572. https://doi.org/10.1128/jvi.74.1.564-572.2000 (2000).
doi: 10.1128/jvi.74.1.564-572.2000
pubmed: 10590151
pmcid: 111573
Holick, M. F. Vitamin D deficiency. N. Engl. J. Med. 357, 266–281. https://doi.org/10.1056/NEJMra070553 (2007).
doi: 10.1056/NEJMra070553
pubmed: 17634462
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. & Mathieu, C. Vitamin D: Modulator of the immune system. Curr. Opin. Pharmacol. 10, 482–496. https://doi.org/10.1016/j.coph.2010.04.001 (2010).
doi: 10.1016/j.coph.2010.04.001
pubmed: 20427238
Nagpal, S., Na, S. & Rathnachalam, R. Noncalcemic actions of vitamin D receptor ligands. Endocr. Rev. 26, 662–687. https://doi.org/10.1210/er.2004-0002 (2005).
doi: 10.1210/er.2004-0002
pubmed: 15798098
Haussler, M. R. et al. Molecular mechanisms of vitamin D action. Calcif. Tissue Int. 92, 77–98. https://doi.org/10.1007/s00223-012-9619-0 (2013).
doi: 10.1007/s00223-012-9619-0
pubmed: 22782502
Kongsbak, M., Levring, T., Geisler, C. & von Essen, M. The vitamin D receptor and T cell function. Front. Immunol. https://doi.org/10.3389/fimmu.2013.00148 (2013).
doi: 10.3389/fimmu.2013.00148
pubmed: 23785369
pmcid: 3684798
Alagarasu, K. et al. In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2. Peptides 92, 23–30. https://doi.org/10.1016/j.peptides.2017.04.002 (2017).
doi: 10.1016/j.peptides.2017.04.002
pubmed: 28400226
Aranow, C. Vitamin D and the immune system. J. Invest. Med. 59, 881–886. https://doi.org/10.2310/JIM.0b013e31821b8755 (2011).
doi: 10.2310/JIM.0b013e31821b8755
Gal-Tanamy, M. et al. Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes. Hepatology 54, 1570–1579. https://doi.org/10.1002/hep.24575 (2011).
doi: 10.1002/hep.24575
pubmed: 21793032
Alvarez, N., Aguilar-Jimenez, W. & Rugeles, M. T. The potential protective role of vitamin D supplementation on HIV-1 infection. Front. Immunol. 10, 2291. https://doi.org/10.3389/fimmu.2019.02291 (2019).
doi: 10.3389/fimmu.2019.02291
pubmed: 31611877
pmcid: 6773828
Gupta, S. et al. The role of micronutrients in the infection and subsequent response to hepatitis C virus. Cells https://doi.org/10.3390/cells8060603 (2019).
doi: 10.3390/cells8060603
pubmed: 31615089
pmcid: 6830093
Alagarasu, K., Bachal, R. V., Bhagat, A. B., Shah, P. S. & Dayaraj, C. Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever. Virol. J. 9, 86. https://doi.org/10.1186/1743-422X-9-86 (2012).
doi: 10.1186/1743-422X-9-86
pubmed: 22559908
pmcid: 3413536
Alagarasu, K. et al. Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection. Hum. Immunol. 73, 1194–1199. https://doi.org/10.1016/j.humimm.2012.08.007 (2012).
doi: 10.1016/j.humimm.2012.08.007
pubmed: 22917542
Puerta-Guardo, H., Hernández, S. I., Rosales, V. H., Ludert, J. E. & del Angel, R. M. The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res. 94, 57–61. https://doi.org/10.1016/j.antiviral.2012.02.006 (2012).
doi: 10.1016/j.antiviral.2012.02.006
pubmed: 22387385
Arboleda Alzate, J. F., Rodenhuis-Zybert, I. A., Hernandez, J. C., Smit, J. M. & Urcuqui-Inchima, S. Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression. PLoS Negl. Trop. Dis. 11, e0005904. https://doi.org/10.1371/journal.pntd.0005904 (2017).
doi: 10.1371/journal.pntd.0005904
pubmed: 29020083
pmcid: 5653353
Xu, B. et al. Discovery of fused bicyclic derivatives of 1H-pyrrolo[1,2-c]imidazol-1-one as VDR signaling regulators. Bioorg Med. Chem. 27, 3879–3888. https://doi.org/10.1016/j.bmc.2019.07.024 (2019).
doi: 10.1016/j.bmc.2019.07.024
pubmed: 31324566
Pike, J. W. & Meyer, M. B. The vitamin D receptor: New paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinol. Metab. Clin. N. Am. 39, 255–269. https://doi.org/10.1016/j.ecl.2010.02.007 (2010) ((table of contents)).
doi: 10.1016/j.ecl.2010.02.007
Bitetto, D. et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. Transpl. Int. 24, 43–50. https://doi.org/10.1111/j.1432-2277.2010.01141.x (2011).
doi: 10.1111/j.1432-2277.2010.01141.x
pubmed: 20649944
Ravid, A. et al. 25-Hydroxyvitamin D inhibits hepatitis C virus production in hepatocellular carcinoma cell line by a vitamin D receptor-independent mechanism. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20092367 (2019).
doi: 10.3390/ijms20092367
pubmed: 31086078
pmcid: 6539257
Giraldo, D. M., Cardona, A. & Urcuqui-Inchima, S. High-dose of vitamin D supplement is associated with reduced susceptibility of monocyte-derived macrophages to dengue virus infection and pro-inflammatory cytokine production: An exploratory study. Clin. Chim. Acta 478, 140–151. https://doi.org/10.1016/j.cca.2017.12.044 (2018).
doi: 10.1016/j.cca.2017.12.044
pubmed: 29289621
Jadhav, N. J., Gokhale, S., Seervi, M., Patil, P. S. & Alagarasu, K. Immunomodulatory effect of 1, 25 dihydroxy vitamin D3 on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages. Int. Immunopharmacol. 62, 237–243. https://doi.org/10.1016/j.intimp.2018.07.019 (2018).
doi: 10.1016/j.intimp.2018.07.019
pubmed: 30032048
Nurminen, V., Seuter, S. & Carlberg, C. Primary vitamin D target genes of human monocytes. Front. Physiol. 10, 194. https://doi.org/10.3389/fphys.2019.00194 (2019).
doi: 10.3389/fphys.2019.00194
pubmed: 30890957
pmcid: 6411690
Heaton, N. S. & Randall, G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host Microbe 8, 422–432. https://doi.org/10.1016/j.chom.2010.10.006 (2010).
doi: 10.1016/j.chom.2010.10.006
pubmed: 21075353
pmcid: 3026642
Lee, Y. R. et al. Autophagic machinery activated by dengue virus enhances virus replication. Virology 374, 240–248. https://doi.org/10.1016/j.virol.2008.02.016 (2008).
doi: 10.1016/j.virol.2008.02.016
pubmed: 18353420
pmcid: 7103294
Panyasrivanit, M., Khakpoor, A., Wikan, N. & Smith, D. R. Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. J. Gen. Virol. 90, 448–456. https://doi.org/10.1099/vir.0.005355-0 (2009).
doi: 10.1099/vir.0.005355-0
pubmed: 19141455
Haas, M. J., Jafri, M., Wehmeier, K. R., Onstead-Haas, L. M. & Mooradian, A. D. Inhibition of endoplasmic reticulum stress and oxidative stress by vitamin D in endothelial cells. Free Radic. Biol. Med. 99, 1–10. https://doi.org/10.1016/j.freeradbiomed.2016.07.020 (2016).
doi: 10.1016/j.freeradbiomed.2016.07.020
pubmed: 27458123
Datan, E. et al. Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation. Cell Death Dis. 7, e2127. https://doi.org/10.1038/cddis.2015.409 (2016).
doi: 10.1038/cddis.2015.409
pubmed: 26938301
pmcid: 4823927
Klomporn, P., Panyasrivanit, M., Wikan, N. & Smith, D. R. Dengue infection of monocytic cells activates ER stress pathways, but apoptosis is induced through both extrinsic and intrinsic pathways. Virology 409, 189–197. https://doi.org/10.1016/j.virol.2010.10.010 (2011).
doi: 10.1016/j.virol.2010.10.010
pubmed: 21047664
Lee, Y. R. et al. Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo. Sci Rep 8, 489. https://doi.org/10.1038/s41598-017-18909-3 (2018).
doi: 10.1038/s41598-017-18909-3
pubmed: 29323257
pmcid: 5765116
Chen, H. H. et al. AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78. Antiviral Res. 142, 158–168. https://doi.org/10.1016/j.antiviral.2017.02.015 (2017).
doi: 10.1016/j.antiviral.2017.02.015
pubmed: 28238876
Thepparit, C. et al. Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res. Notes 6, 372. https://doi.org/10.1186/1756-0500-6-372 (2013).
doi: 10.1186/1756-0500-6-372
pubmed: 24034452
pmcid: 3847886
Wati, S. et al. Dengue virus infection induces upregulation of GRP78, which acts to chaperone viral antigen production. J. Virol. 83, 12871–12880. https://doi.org/10.1128/JVI.01419-09 (2009).
doi: 10.1128/JVI.01419-09
pubmed: 19793816
pmcid: 2786853
Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90, 8392–8396 (1993).
doi: 10.1073/pnas.90.18.8392
Holick, M. F. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev. Endocr. Metab. Disord. 18, 153–165. https://doi.org/10.1007/s11154-017-9424-1 (2017).
doi: 10.1007/s11154-017-9424-1
pubmed: 28516265
Villamor, E., Villar, L. A., Lozano, A., Herrera, V. M. & Herran, O. F. Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. Epidemiol. Infect. 145, 2961–2970. https://doi.org/10.1017/S0950268817002059 (2017).
doi: 10.1017/S0950268817002059
pubmed: 28903788
Sanchez-Valdez, E., Delgado-Aradillas, M., Torres-Martinez, J. A. & Torres-Benitez, J. M. Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: Study of 5 cases. Proc. West. Pharmacol. Soc. 52, 14–17 (2009).
pubmed: 22128411
Sithisarn, P., Suksanpaisan, L., Thepparit, C. & Smith, D. R. Behavior of the dengue virus in solution. J. Med. Virol. 71, 532–539 (2003).
doi: 10.1002/jmv.10520
Henchal, E. A., Gentry, M. K., McCown, J. M. & Brandt, W. E. Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence. Am. J. Trop. Med. Hyg. 31, 830–836 (1982).
doi: 10.4269/ajtmh.1982.31.830