Smoking and Epstein-Barr virus infection in multiple sclerosis development.
Adolescent
Adult
Aged
Antibodies, Viral
/ blood
Case-Control Studies
Epstein-Barr Virus Infections
/ complications
Epstein-Barr Virus Nuclear Antigens
/ immunology
Female
Herpesvirus 4, Human
/ immunology
Humans
Immunoglobulin G
/ blood
Infectious Mononucleosis
/ complications
Male
Middle Aged
Multiple Sclerosis
/ epidemiology
Registries
Risk Factors
Sweden
Tobacco Smoking
/ adverse effects
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 07 2020
03 07 2020
Historique:
received:
18
11
2019
accepted:
29
05
2020
entrez:
5
7
2020
pubmed:
6
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
It is unclear whether smoking interacts with different aspects of Epstein-Barr virus (EBV) infection with regard to multiple sclerosis (MS) risk. We aimed to investigate whether smoking acts synergistically with elevated EBNA-1 antibody levels or infectious mononucleosis (IM) history regarding MS risk. Two Swedish population-based case-control studies were used (6,340 cases and 6,219 matched controls). Subjects with different smoking, EBNA-1 and IM status were compared regarding MS risk, by calculating odds ratios (OR) with 95% confidence intervals (CI) employing logistic regression. Potential interaction on the additive scale was evaluated by calculating the attributable proportion due to interaction (AP). Current and past smokers had higher EBNA-1 antibody levels than never smokers (p < 0.0001). There was an additive interaction between current smoking and high EBNA-1 antibody levels (AP 0.3, 95% CI 0.2-0.4), but not between past smoking and high EBNA-1 antibody levels (AP 0.01, 95% CI - 0.1 to 0.1), with regard to MS risk. An interaction also occurred between current smoking and IM history (AP 0.2, 95% CI 0.004-0.4), but not between past smoking and IM history (AP - 0.06, 95% CI - 0.4 to 0.3). Current smoking increases EBNA-1 antibody levels and acts synergistically with both aspects of EBV infection to increase MS risk, indicating that there is at least one pathway to disease in which both risk factors are involved.
Identifiants
pubmed: 32620875
doi: 10.1038/s41598-020-67883-w
pii: 10.1038/s41598-020-67883-w
pmc: PMC7335184
doi:
Substances chimiques
Antibodies, Viral
0
Epstein-Barr Virus Nuclear Antigens
0
Immunoglobulin G
0
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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