A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.

Adult Connectome / psychology Deep Brain Stimulation / instrumentation Electrodes, Implanted Female Follow-Up Studies Humans Internal Capsule / physiopathology Magnetic Resonance Imaging Male Middle Aged Models, Neurological Nerve Net / physiopathology Nucleus Accumbens / physiopathology Obsessive-Compulsive Disorder / physiopathology Postoperative Period Preoperative Period Prognosis Retrospective Studies Subthalamic Nucleus / physiopathology Tomography, X-Ray Computed Treatment Outcome Young Adult

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 07 2020
Historique:
received: 13 04 2019
accepted: 21 05 2020
entrez: 5 7 2020
pubmed: 6 7 2020
medline: 29 8 2020
Statut: epublish

Résumé

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients (N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbens or the subthalamic nucleus (STN). The same fiber bundle was associated with optimal clinical response in cohorts targeting either structure. This bundle connected frontal regions to the STN. When informing the tract target based on the first cohort, clinical improvements in the second could be significantly predicted, and vice versa. To further confirm results, clinical improvements in eight patients from a third center and six patients from a fourth center were significantly predicted based on their stimulation overlap with this tract. Our results show that connectivity-derived models may inform clinical improvements across DBS targets, surgeons and centers. The identified tract target is openly available in atlas form.

Identifiants

DOI: 10.1038/s41467-020-16734-3 PMID: 32620886 PMC: PMC7335093
pubmed: 32620886
doi: 10.1038/s41467-020-16734-3
pii: 10.1038/s41467-020-16734-3
pmc: PMC7335093
doi:

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3364

Subventions

Organisme : Medical Research Council
ID : MR/J012009/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States

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Auteurs

Ningfei Li (N)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology, Charitéplatz 1, 10117 Berlin, Germany. ningfei.li@charite.de.
ORCID: 0000-0003-3315-3591

Juan Carlos Baldermann (JC)

Department of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical Faculty, Cologne, Germany.

Astrid Kibleur (A)

Univ. Grenoble Alpes, 38000, Grenoble, France.
OpenMind Innovation, 75008, Paris, France.

Svenja Treu (S)

Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid, Madrid, Spain.

Harith Akram (H)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.
ORCID: 0000-0002-2899-628X

Gavin J B Elias (GJB)

University Health Network, Toronto, ON, Canada.

Alexandre Boutet (A)

University Health Network, Toronto, ON, Canada.
Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0001-6942-5195

Andres M Lozano (AM)

University Health Network, Toronto, ON, Canada.

Bassam Al-Fatly (B)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology, Charitéplatz 1, 10117 Berlin, Germany.
ORCID: 0000-0003-0067-6177

Bryan Strange (B)

Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid, Madrid, Spain.
ORCID: 0000-0001-6476-4091

Juan A Barcia (JA)

Hospital Clínico San Carlos, Neurosurgery Department, Universidad Complutense de Madrid, Madrid, Spain.

Ludvic Zrinzo (L)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.
ORCID: 0000-0002-6013-4946

Eileen Joyce (E)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.
ORCID: 0000-0003-0469-2844

Stephan Chabardes (S)

Univ. Grenoble Alpes, 38000, Grenoble, France.

Veerle Visser-Vandewalle (V)

Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany.

Mircea Polosan (M)

Univ. Grenoble Alpes, 38000, Grenoble, France.
Inserm, U1216, Grenoble Institut des Neurosciences, 38000, Grenoble, France.
Psychiatry Department, CHU Grenoble Alpes, 38000, Grenoble, France.

Jens Kuhn (J)

Department of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical Faculty, Cologne, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatics, EVKLN, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Andrea A Kühn (AA)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology, Charitéplatz 1, 10117 Berlin, Germany.

Andreas Horn (A)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology, Charitéplatz 1, 10117 Berlin, Germany.
ORCID: 0000-0002-0695-6025

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A unified connectomic target for deep brain...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Connectome › A unified connectomic target for deep brain...
questionsmedicales.fr › Procédures de chirurgie opératoire › Stimulation cérébrale profonde › A unified connectomic target for deep brain...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › A unified connectomic target for deep brain...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › A unified connectomic target for deep brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A unified connectomic target for deep brain...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Capsule interne › A unified connectomic target for deep brain...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › A unified connectomic target for deep brain...
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questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles neurologiques › A unified connectomic target for deep brain...
questionsmedicales.fr › Système nerveux › Réseau nerveux › A unified connectomic target for deep brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › A unified connectomic target for deep brain...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › A unified connectomic target for deep brain...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Période périopératoire › Période postopératoire › A unified connectomic target for deep brain...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Période périopératoire › Période préopératoire › A unified connectomic target for deep brain...
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