Chiral differentiation of l- and d-penicillamine by β-cyclodextrin: Investigated by IRMPD spectroscopy and theoretical simulations.

Hydrogen Bonding Molecular Dynamics Simulation Penicillamine Spectrum Analysis beta-Cyclodextrins
Chirality Cyclodextrin IRMPD spectroscopy Penicillamine Theoretical simulations

Journal

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533

Informations de publication

Date de publication:
05 Nov 2020
Historique:
received: 02 05 2020
revised: 24 06 2020
accepted: 24 06 2020
pubmed: 6 7 2020
medline: 15 5 2021
entrez: 6 7 2020
Statut: ppublish

Résumé

The chirality of penicillamine (Peni) results in different clinic applications. Host-guest complex based drug delivery system that differentiates the two enantiomers and provides delayed release is of significance in medication. We hereby used β-CD to encapsulate d- and l-Peni. IRMPD spectra show different characteristic vibrations to distinguish the two enantiomers. Besides common peaks found at 3000-3100 cm

Identifiants

DOI: 10.1016/j.saa.2020.118653 PMID: 32623304
pubmed: 32623304
pii: S1386-1425(20)30632-6
doi: 10.1016/j.saa.2020.118653
pii:
doi:

Substances chimiques

beta-Cyclodextrins 0
Penicillamine GNN1DV99GX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

118653

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Lu Sun (L)

Institute of Modern Optics, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Nankai University, Tianjin 300071, PR China; Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi, China.

Fan Huang (F)

Institute of Modern Optics, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Nankai University, Tianjin 300071, PR China.

Weiwei Liu (W)

Institute of Modern Optics, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Nankai University, Tianjin 300071, PR China.

Lie Lin (L)

Institute of Modern Optics, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Nankai University, Tianjin 300071, PR China.

Yin Hong (Y)

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Xianglei Kong (X)

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 30007, China. Electronic address: kongxianglei@nankai.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Chiral differentiation of l- and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Chiral differentiation of l- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Pénicillamine › Chiral differentiation of l- and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Chiral differentiation of l- and...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines bêta › Chiral differentiation of l- and...