Severe inflammatory myopathy in a pulmonary carcinoma patient treated with Pembrolizumab: An alert for myologists.

Antibodies, Monoclonal, Humanized / adverse effects Antineoplastic Agents, Immunological / adverse effects Carcinoma / drug therapy Fatal Outcome Humans Lung Neoplasms / drug therapy Myositis / drug therapy Myotoxicity / etiology
Pembrolizumab immune-checkpoint inhibitors immune-correlated adverse events inflammatory myopathy pulmonary carcinoma

Journal

Journal of neuromuscular diseases
ISSN: 2214-3602
Titre abrégé: J Neuromuscul Dis
Pays: Netherlands
ID NLM: 101649948

Informations de publication

Date de publication:
2020
Historique:
pubmed: 6 7 2020
medline: 23 7 2021
entrez: 6 7 2020
Statut: ppublish

Résumé

Immune-related adverse events (irAE) during the administration of immune-checkpoint inhibitors (ICIs) become more evident due to the increased use of these therapies. To remind the importance of early recognition of this phenomenon, we report a paradigmatic case characterized by severe systemic inflammatory myopathy and severe cardiac involvement that abruptly precipitated in an untoward ending after one single dose of Pembrolizumab.

Identifiants

DOI: 10.3233/JND-200504 PMID: 32623405
pubmed: 32623405
pii: JND200504
doi: 10.3233/JND-200504
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
Antineoplastic Agents, Immunological 0
pembrolizumab DPT0O3T46P

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-514

Auteurs

L Peverelli (L)

ASST Lodi, Ospedale Maggiore di Lodi, Neurology Unit, Lodi, Italy.

A De Rosa (A)

Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

E Domina (E)

ASST Lodi, Ospedale Maggiore di Lodi, Neurology Unit, Lodi, Italy.

P Ciscato (P)

Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

G Sita (G)

ASST Lodi, Ospedale Maggiore di Lodi, Oncology Unit, Lodi, Italy.

D Velardo (D)

Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

G P Comi (GP)

Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Issue fatale › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Maladies musculaires › Myosite › Severe inflammatory myopathy in a pulmonary...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Myotoxicité › Severe inflammatory myopathy in a pulmonary...