Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.

Activating Transcription Factor 4 / genetics Apoptosis / drug effects Blotting, Western Cell Cycle / drug effects Cell Line, Tumor Cell Proliferation / drug effects Cladribine / pharmacology Endoplasmic Reticulum Stress / drug effects Humans Lymphoma, Large B-Cell, Diffuse / metabolism Real-Time Polymerase Chain Reaction Vorinostat / pharmacology
ATF4 DLBCL SAHA apoptosis cladribine

Journal

International journal of medical sciences
ISSN: 1449-1907
Titre abrégé: Int J Med Sci
Pays: Australia
ID NLM: 101213954

Informations de publication

Date de publication:
2020
Historique:
received: 04 11 2019
accepted: 23 05 2020
entrez: 7 7 2020
pubmed: 7 7 2020
medline: 9 3 2021
Statut: epublish

Résumé

Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. The therapeutic role of cladribine against diffuse large B-cell lymphoma cells (DLBCL) is still undefined. In the present study, we demonstrated that cladribine inhibited cell proliferation and induced G

Identifiants

DOI: 10.7150/ijms.41793 PMID: 32624694 PMC: PMC7330656
pubmed: 32624694
doi: 10.7150/ijms.41793
pii: ijmsv17p1375
pmc: PMC7330656
doi:

Substances chimiques

ATF4 protein, human 0
Activating Transcription Factor 4 145891-90-3
Cladribine 47M74X9YT5
Vorinostat 58IFB293JI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1375-1384

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Références

Arch Biochem Biophys. 2016 Nov 1;609:39-50
pubmed: 27638049
Cancers (Basel). 2013 Apr 15;5(2):430-61
pubmed: 24216985
Front Oncol. 2019 Mar 01;9:107
pubmed: 30881917
FEBS J. 2016 Jul;283(14):2640-52
pubmed: 26587781
Expert Opin Investig Drugs. 2009 Aug;18(8):1169-81
pubmed: 19604118
Br J Haematol. 2018 Sep;182(5):633-643
pubmed: 29808921
Arch Pharm Res. 2015 Jun;38(6):933-49
pubmed: 25653088
Biochem Pharmacol. 2003 Jan 15;65(2):219-25
pubmed: 12504797
Br J Haematol. 2019 Sep;186(6):845-854
pubmed: 31177537
Leukemia. 2002 Oct;16(10):2106-14
pubmed: 12357364
Leukemia. 2000 Feb;14(2):299-306
pubmed: 10673748
Cell. 2012 Jul 6;150(1):12-27
pubmed: 22770212
Biochem J. 2001 Nov 1;359(Pt 3):537-46
pubmed: 11672427
Am J Transl Res. 2013;5(1):36-46
pubmed: 23390564
Mol Cancer Ther. 2012 Oct;11(10):2174-82
pubmed: 22848091
Blood. 2010 Oct 21;116(16):2884-96
pubmed: 20634380
Leuk Lymphoma. 2011 Jun;52 Suppl 2:43-5
pubmed: 21463108
Mol Neurobiol. 2016 Jan;53(1):532-544
pubmed: 25482050
Am J Hematol. 2015 Jan;90(1):62-72
pubmed: 25284482
Blood. 2015 Jan 1;125(1):22-32
pubmed: 25499448
Semin Hematol. 2008 Jan;45(1):23-30
pubmed: 18179966
J Proteome Res. 2011 Mar 4;10(3):1030-42
pubmed: 21182289
Leuk Lymphoma. 2011 Aug;52(8):1488-94
pubmed: 21623691
Lancet. 1992 Oct 17;340(8825):952-6
pubmed: 1357355
Biochem Pharmacol. 2007 Feb 1;73(3):351-8
pubmed: 17137556
Cancer. 2018 Dec 15;124(24):4622-4632
pubmed: 30252929
Expert Opin Pharmacother. 2013 Jan;14(1):123-36
pubmed: 23256518
Clin Exp Immunol. 2013 Aug;173(2):288-97
pubmed: 23607690
Pharmacol Ther. 2017 May;173:118-134
pubmed: 28188812
Asian Pac J Cancer Prev. 2015;16(6):2129-44
pubmed: 25824729
Mol Cancer Ther. 2017 Jul;16(7):1246-1256
pubmed: 28428442
Leuk Lymphoma. 2014 Sep;55(9):1980-92
pubmed: 24295132
Exp Hematol. 2016 Jun;44(6):458-65
pubmed: 26976752
Int J Oncol. 2008 Jun;32(6):1325-33
pubmed: 18497995
Leuk Lymphoma. 2018 Jun;59(6):1482-1485
pubmed: 28914567
Hematol Oncol. 2017 Jun;35(2):177-186
pubmed: 26580149
Int J Mol Med. 2017 Dec;40(6):1957-1964
pubmed: 29039478
ScientificWorldJournal. 2014;2014:928036
pubmed: 25431797
Curr Mol Med. 2016;16(6):533-44
pubmed: 27211800
Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103
pubmed: 25936818
BMC Cancer. 2011 Jun 16;11:255
pubmed: 21679466
Phys Biol. 2016 May 11;13(3):031001
pubmed: 27172135
Front Oncol. 2018 Sep 10;8:351
pubmed: 30250823
Neurotherapeutics. 2017 Oct;14(4):874-887
pubmed: 29168160
Br J Haematol. 2015 Feb;168(3):371-83
pubmed: 25284154
Clin Genet. 2012 Apr;81(4):303-11
pubmed: 22082348
Biochim Biophys Acta. 2014 Oct;1843(10):2143-9
pubmed: 24440276
Cell. 2017 Feb 9;168(4):692-706
pubmed: 28187289
J Biol Chem. 2006 Sep 8;281(36):26675-82
pubmed: 16840788
Ann Hematol. 2002 Sep;81(9):508-13
pubmed: 12373351
Blood. 1983 Oct;62(4):737-43
pubmed: 6136305
Int J Mol Sci. 2017 Jul 01;18(7):
pubmed: 28671573

Auteurs

Linyan Xu (L)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Jun Jiao (J)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Xiaoshen Sun (X)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Wei Sang (W)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Xiang Gao (X)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Pu Yang (P)

Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.

Dongmei Yan (D)

Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Xuguang Song (X)

Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Cai Sun (C)

Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Mengdi Liu (M)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Yuanyuan Qin (Y)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Yu Tian (Y)

Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Feng Zhu (F)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Lingyu Zeng (L)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Zhenyu Li (Z)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

Kailin Xu (K)

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription ATF › Facteur de transcription ATF-4 › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunotransfert › Technique de Western › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Chloro-2 adénosine › Chloro-2 désoxyadénosine › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Stress du réticulum endoplasmique › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Réaction de polymérisation en chaîne › Réaction de polymérisation en chaine en temps réel › Cladribine Induces ATF4 Mediated Apoptosis and...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Acides hydroxamiques › Vorinostat › Cladribine Induces ATF4 Mediated Apoptosis and...