Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.

Cyclooxygenase 2 / metabolism Kidney Glomerulus / metabolism Mechanotransduction, Cellular / physiology Podocytes / metabolism Proteoglycans / metabolism Receptors, Prostaglandin E, EP2 Subtype / metabolism Stress, Mechanical TOR Serine-Threonine Kinases / metabolism Transcriptional Activation / physiology Up-Regulation
Integrative MultiOmics Pathway Resolution fluid flow shear stress galactose metabolism glycocalyx hyperfiltration podocytes

Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 08 2020
Historique:
pubmed: 7 7 2020
medline: 7 10 2020
entrez: 7 7 2020
Statut: ppublish

Résumé

The ultrafiltrate flow over the major processes and cell body generates fluid flow shear stress (FFSS) on podocytes. Hyperfiltration-associated increase in FFSS can lead to podocyte injury and detachment. Previously, we showed that FFSS-induced upregulation of the cyclooxygenase 2 (COX2)-PGE

Identifiants

DOI: 10.1152/ajprenal.00183.2020 PMID: 32628542 PMC: PMC7473905
pubmed: 32628542
doi: 10.1152/ajprenal.00183.2020
pmc: PMC7473905
doi:

Substances chimiques

Proteoglycans 0
Receptors, Prostaglandin E, EP2 Subtype 0
Cyclooxygenase 2 EC 1.14.99.1
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

F312-F322

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK107490
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : R01DK064969
Pays : International
Organisme : BLRD VA
ID : I01 BX001037
Pays : United States
Organisme : U.S. Department of Veterans Affairs (VA)
ID : BX001037
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK064969
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : R01DK107490
Pays : International

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Auteurs

Tarak Srivastava (T)

Section of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.
Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Department of Oral and Craniofacial Sciences, University of Missouri School of Dentistry, Kansas City, Missouri.

Trupti Joshi (T)

Department of Health Management and Informatics and University of Missouri Informatics Institute, University of Missouri, Columbia, Missouri.
Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
MU Data Science and Informatics Institute, University of Missouri, Columbia, Missouri.

Yuexu Jiang (Y)

Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.

Daniel P Heruth (DP)

Children's Mercy Research Institute, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.

Mohamed H Rezaiekhaligh (MH)

Section of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.

Jan Novak (J)

Department of Microbiology, University of Alabama, Birmingham, Alabama.

Vincent S Staggs (VS)

Biostatistics and Epidemiology Core, Children's Mercy Kansas City, Department of Pediatrics, University of Missouri, Kansas City, Missouri.

Uri S Alon (US)

Section of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.

Robert E Garola (RE)

Department of Pathology and Laboratory Medicine, Children's Mercy Hospital and University of Missouri, Kansas City.

Ashraf El-Meanawy (A)

Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Ellen T McCarthy (ET)

Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.

Jianping Zhou (J)

Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Varun C Boinpelly (VC)

Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Ram Sharma (R)

Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Virginia J Savin (VJ)

Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Mukut Sharma (M)

Midwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Glomérule rénal › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mécanotransduction cellulaire › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéoglycanes › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur prostaglandine › Récepteur prostaglandine E › Sous-type EP2 des récepteurs des prostaglandines E › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Upregulated proteoglycan-related signaling...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Upregulated proteoglycan-related signaling...