TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy.

Animals Humans TOR Serine-Threonine Kinases / metabolism Lupus Erythematosus, Systemic / immunology Arthritis, Rheumatoid / immunology Autophagy Mice Female Male Mice, Knockout Autoantibodies / blood Adult Antibody Formation Leukocytes, Mononuclear / metabolism Middle Aged Membrane Proteins / genetics Signal Transduction Disease Models, Animal B-Lymphocytes / immunology Mice, Inbred C57BL
TM9SF1 Antibody Autophagy Disease activity Predictive capability Rheumatoid arthritis Systemic lupus erythematosus

Journal

BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723

Informations de publication

Date de publication:
31 Oct 2024
Historique:
received: 08 03 2024
accepted: 25 10 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression and autoimmune disease activity. As B cell differentiation and autoantibody production exacerbate autoimmune disease, the signaling pathways involved in these processes were explored. Tm9sf1 The Tm9sf1 The primary finding was the identification of the molecular mechanism underlying autophagy regulation in B cells, in which Tm9sf1 knockout was found to modulate mTOR-dependent autophagy to block B cell differentiation into antibody-secreting plasma cells. It was also found that TM9SF1 expression level in PBMCs was an accurate indicator of disease activity in patients with RA and SLE, suggesting its clinical potential for monitoring disease activity in these patients.

Sections du résumé

BACKGROUND BACKGROUND
Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression and autoimmune disease activity. As B cell differentiation and autoantibody production exacerbate autoimmune disease, the signaling pathways involved in these processes were explored.
METHODS METHODS
Tm9sf1
RESULTS RESULTS
The Tm9sf1
CONCLUSIONS CONCLUSIONS
The primary finding was the identification of the molecular mechanism underlying autophagy regulation in B cells, in which Tm9sf1 knockout was found to modulate mTOR-dependent autophagy to block B cell differentiation into antibody-secreting plasma cells. It was also found that TM9SF1 expression level in PBMCs was an accurate indicator of disease activity in patients with RA and SLE, suggesting its clinical potential for monitoring disease activity in these patients.

Identifiants

DOI: 10.1186/s12916-024-03729-w PMID: 39482663
pubmed: 39482663
doi: 10.1186/s12916-024-03729-w
pii: 10.1186/s12916-024-03729-w
doi:

Substances chimiques

TOR Serine-Threonine Kinases EC 2.7.11.1
Autoantibodies 0
Membrane Proteins 0
MTOR protein, human EC 2.7.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

502

Informations de copyright

© 2024. The Author(s).

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Auteurs

Juan Xiao (J)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Zhenwang Zhao (Z)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Fengqiao Zhou (F)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Jinsong Xiong (J)

Gucheng People's Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441700, China.

Zean Yang (Z)

Gucheng People's Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441700, China.

Baoxian Gong (B)

Gucheng People's Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441700, China.

Lei Xiang (L)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Mingming Liu (M)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Fengsheng Cao (F)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Hong Xiao (H)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.

Huabo Chen (H)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. chenhb@hbuas.edu.cn.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. chenhb@hbuas.edu.cn.

Anbing Zhang (A)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. xf_zab@sina.com.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. xf_zab@sina.com.

Ke Wang (K)

Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. wangk201912@hbuas.edu.cn.
Department of Rheumatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China. wangk201912@hbuas.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › TM9SF1 expression correlates with autoimmune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › TM9SF1 expression correlates with autoimmune...