Intergenerational transmission of childhood trauma? Testing cellular aging in mothers exposed to sexual abuse and their children.
Adult
Adult Survivors of Child Abuse
/ psychology
Adverse Childhood Experiences
/ psychology
Cellular Senescence
/ genetics
Child
Cohort Studies
Female
Humans
Intergenerational Relations
Longitudinal Studies
Male
Mothers
Prospective Studies
Sex Offenses
Telomere
/ metabolism
Telomere Homeostasis
/ physiology
Child sexual abuse
Intergenerational transmission of trauma
Telomere length
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
02
2020
revised:
10
06
2020
accepted:
19
06
2020
pubmed:
7
7
2020
medline:
20
7
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Exposure to maltreatment in childhood can lead to increased risk for poor health outcomes in adulthood. Child maltreatment and later poor health may be linked by premature biological aging. We tested whether childhood sexual abuse (CSA) was associated with telomere length (TL) in adult females. We further tested the hypothesis of intergenerational transmission of CSA-related effects by measuring TL in both CSA-exposed and non-exposed mothers and their children. Participants were a subset of females and their children in a prospective-longitudinal cohort study of sexually abused females and a demographically comparable control group from the same Washington, D.C. area. TL was measured using qPCR in both leukocyte and buccal samples from females (N = 108, mean age 36.3 years) and buccal samples from their children (N = 124, mean age 10.5 years). Multilevel models were used to test associations between CSA-exposure and TL measured in leukocytes and buccal tissue in females and to test the intergenerational effect of maternal-CSA exposure on age-adjusted TL in their children. CSA-exposure was not associated with TL in adult females. Maternal TL and biological sex were significant predictors of child TL such that longer maternal TL predicted longer TL in children, and female children had longer TL than male children. However, maternal-CSA exposure did not predict TL in children. CSA-exposure was not associated with TL in this cohort of middle-aged females, nor was there evidence for an intergenerational effect of maternal-CSA exposure on child TL. This finding is in line with some previous results on CSA and adult TL. Previous significant results associating child maltreatment with shorter TL may be capturing a population of individuals exposed to either multiple types of maltreatment compared to controls with no childhood adversity, or maltreatment in childhood with concurrent TL measurements.
Sections du résumé
BACKGROUND
Exposure to maltreatment in childhood can lead to increased risk for poor health outcomes in adulthood. Child maltreatment and later poor health may be linked by premature biological aging. We tested whether childhood sexual abuse (CSA) was associated with telomere length (TL) in adult females. We further tested the hypothesis of intergenerational transmission of CSA-related effects by measuring TL in both CSA-exposed and non-exposed mothers and their children.
METHODS
Participants were a subset of females and their children in a prospective-longitudinal cohort study of sexually abused females and a demographically comparable control group from the same Washington, D.C. area. TL was measured using qPCR in both leukocyte and buccal samples from females (N = 108, mean age 36.3 years) and buccal samples from their children (N = 124, mean age 10.5 years). Multilevel models were used to test associations between CSA-exposure and TL measured in leukocytes and buccal tissue in females and to test the intergenerational effect of maternal-CSA exposure on age-adjusted TL in their children.
RESULTS
CSA-exposure was not associated with TL in adult females. Maternal TL and biological sex were significant predictors of child TL such that longer maternal TL predicted longer TL in children, and female children had longer TL than male children. However, maternal-CSA exposure did not predict TL in children.
DISCUSSION
CSA-exposure was not associated with TL in this cohort of middle-aged females, nor was there evidence for an intergenerational effect of maternal-CSA exposure on child TL. This finding is in line with some previous results on CSA and adult TL. Previous significant results associating child maltreatment with shorter TL may be capturing a population of individuals exposed to either multiple types of maltreatment compared to controls with no childhood adversity, or maltreatment in childhood with concurrent TL measurements.
Identifiants
pubmed: 32629221
pii: S0306-4530(20)30202-X
doi: 10.1016/j.psyneuen.2020.104781
pmc: PMC7502488
mid: NIHMS1605503
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104781Subventions
Organisme : NIEHS NIH HHS
ID : U01 ES030949
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD089922
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072468
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055621
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048791
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049676
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Mol Psychiatry. 2012 Jul;17(7):719-27
pubmed: 21577215
J Pediatr Psychol. 2016 Jan-Feb;41(1):37-45
pubmed: 25797944
Child Abuse Negl. 2008 Jun;32(6):607-19
pubmed: 18565580
Soc Sci Med. 2013 May;85:1-8
pubmed: 23540359
Biol Psychiatry. 2010 Sep 15;68(6):e21-2; author reply e23-4
pubmed: 20678755
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):
pubmed: 29335381
PLoS One. 2014 Sep 08;9(9):e103483
pubmed: 25198730
J Psychiatr Res. 2016 Mar;74:87-93
pubmed: 26774419
R Soc Open Sci. 2018 Aug 29;5(8):180744
pubmed: 30225068
Int J Epidemiol. 2016 Aug;45(4):1295-1298
pubmed: 27581804
Child Abuse Negl. 2009 Mar;33(3):127-38
pubmed: 19328548
Psychiatry Res. 2016 Dec 30;246:95-100
pubmed: 27677058
J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):1-12
pubmed: 14741005
Eur J Hum Genet. 2014 Jan;22(1):8-9
pubmed: 24022299
J Affect Disord. 2017 Apr 15;213:16-22
pubmed: 28187293
J Behav Med. 2019 Oct;42(5):911-923
pubmed: 30671916
Diabetes Metab Syndr Obes. 2013 Oct 24;6:403-19
pubmed: 24179379
Child Maltreat. 2020 Feb;25(1):20-31
pubmed: 31284731
Child Abuse Negl. 2009 Jul;33(7):412-20
pubmed: 19596434
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Annu Rev Psychol. 2011;62:531-58
pubmed: 21126184
Mol Psychiatry. 2018 Apr;23(4):858-871
pubmed: 28322278
JAMA Psychiatry. 2015 Nov;72(11):1135-42
pubmed: 26465073
Am J Psychiatry. 2013 Jun;170(6):616-23
pubmed: 23732967
Pediatrics. 2007 Jul;120(1):e61-7
pubmed: 17606550
Psychol Bull. 2011 Nov;137(6):959-97
pubmed: 21787044
Psychoneuroendocrinology. 2018 Feb;88:38-46
pubmed: 29161636
Child Abuse Negl. 2004 Jul;28(7):723-7
pubmed: 15261467
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
J Interpers Violence. 2009 Mar;24(3):424-49
pubmed: 18451100
Psychoneuroendocrinology. 2018 Sep;95:74-85
pubmed: 29803183
JAMA Psychiatry. 2019 Jun 1;76(6):584-593
pubmed: 30892562
Am J Psychiatry. 2020 Jan 1;177(1):47-57
pubmed: 31509004
Psychoneuroendocrinology. 2013 Sep;38(9):1835-42
pubmed: 23639252
Mech Ageing Dev. 2000 Nov 15;119(3):89-99
pubmed: 11080530
J Child Psychol Psychiatry. 2016 Oct;57(10):1103-12
pubmed: 27647050
Nat Hum Behav. 2020 Aug;4(8):811-818
pubmed: 32424258
PLoS One. 2015 Jun 08;10(6):e0124493
pubmed: 26053088
Eur J Hum Genet. 2013 Oct;21(10):1163-8
pubmed: 23321625
Psychosom Med. 2011 Jan;73(1):16-22
pubmed: 21148804
PLoS One. 2014 May 09;9(5):e97102
pubmed: 24816913
Biol Psychiatry. 2010 Mar 15;67(6):531-4
pubmed: 19828140
PLoS One. 2010 May 25;5(5):e10826
pubmed: 20520834
Psychosom Med. 2004 May-Jun;66(3):411-21
pubmed: 15184705
Nat Rev Neurosci. 2016 Sep 19;17(10):652-66
pubmed: 27640984
BJOG. 2006 Mar;113(3):318-23
pubmed: 16487204
Child Abuse Negl. 2007 Jan;31(1):7-26
pubmed: 17224181
Nat Commun. 2013;4:1597
pubmed: 23511462
J Pediatr Psychol. 2010 Jun;35(5):450-61
pubmed: 20022919
Bioessays. 2012 Nov;34(11):943-52
pubmed: 22991129
Dev Psychopathol. 2011 May;23(2):453-76
pubmed: 23786689
Biol Psychiatry. 2016 Jul 1;80(1):23-32
pubmed: 26166230
Am J Psychiatry. 2020 Jan 1;177(1):7-9
pubmed: 31892296
Mol Psychiatry. 2013 May;18(5):576-81
pubmed: 22525489
Child Maltreat. 2003 Nov;8(4):319-33
pubmed: 14604178