The 5-Ws of immunotherapy in head and neck cancer.

Head and Neck Neoplasms / therapy Humans Immunologic Factors Immunotherapy Squamous Cell Carcinoma of Head and Neck / therapy Tumor Microenvironment
Head and neck cancer Immune checkpoint inhibitors Immunosuppressive microenvironment Immunotherapy PD-1/PD-L1 axis

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 15 01 2020
revised: 11 06 2020
accepted: 29 06 2020
pubmed: 7 7 2020
medline: 25 9 2020
entrez: 7 7 2020
Statut: ppublish

Résumé

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Recent clinical trials showed that only a small subset of patients really benefits from immunotherapy. This review aims to highlight the five W-points of immunotherapy: why immunotherapy is promising in HNSCC, what is currently available in daily clinical practice, when immunotherapy can be integrated into the therapeutic strategy, where it can be useful according to predictive response biomarker, who, among patients, could get the best benefit from immunotherapy and how improve the achieved results.

Identifiants

DOI: 10.1016/j.critrevonc.2020.103041 PMID: 32629362
pubmed: 32629362
pii: S1040-8428(20)30178-5
doi: 10.1016/j.critrevonc.2020.103041
pii:
doi:

Substances chimiques

Immunologic Factors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103041

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Andrea Botticelli (A)

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

Silvia Mezi (S)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy. Electronic address: silvia.mezi@uniroma1.it.

Giulia Pomati (G)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Bruna Cerbelli (B)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Christiana Di Rocco (C)

Istituto Dermopatico dell'immacolata, IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.

Sasan Amirhassankhani (S)

MSc Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge Rd, Bishop's, London, SE1 7EH, UK.

Grazia Sirgiovanni (G)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Mario Occhipinti (M)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Valerio Napoli (V)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Alessandra Emiliani (A)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Federica Mazzuca (F)

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

Silverio Tomao (S)

Radiological, Oncological and Pathological Science Department "Sapienza", University of Rome, Policlinico Umberto I, Viale Regina Elena 326, 00161, Rome, Italy.

Marianna Nuti (M)

Department of Experimental Medicine, Faculty of Medicine and Dentistry, Sapienza University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

Paolo Marchetti (P)

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › The 5-Ws of immunotherapy in head and neck cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The 5-Ws of immunotherapy in head and neck cancer.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › The 5-Ws of immunotherapy in head and neck cancer.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › The 5-Ws of immunotherapy in head and neck cancer.
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › The 5-Ws of immunotherapy in head and neck cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › The 5-Ws of immunotherapy in head and neck cancer.