New Horizons: Novel Adrenal Regenerative Therapies.
adrenal
adrenal insufficiency
cell replacement
gene therapy
regenerative therapies
stem cells
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
27
05
2020
accepted:
02
07
2020
pubmed:
7
7
2020
medline:
24
2
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, neuroendocrine, and mental perturbations. Therefore, regenerative and more curative strategies would be desirable. In the current perspective, we describe emerging new regenerative therapies for the treatment of adrenal insufficiency. In particular, we discuss gene therapy and cell replacement strategies. Furthermore, we discuss how adrenal cells might be used as a source for regenerative therapies of nonadrenal neurodegenerative diseases such as Parkinson disease.
Identifiants
pubmed: 32629476
pii: 5868096
doi: 10.1210/clinem/dgaa438
pmc: PMC7398608
pii:
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Endocrine Society 2020.
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