Inflammasome and Mitophagy Connection in Health and Disease.
infection
inflammasome
inflammation
mitophagy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
02
06
2020
revised:
26
06
2020
accepted:
28
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
17
2
2021
Statut:
epublish
Résumé
The inflammasome is a large intracellular protein complex that activates inflammatory caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an essential role in the maintenance of mitochondrial homeostasis during stress. Previous studies have indicated compelling evidence of the crosstalk between inflammasome and mitophagy. Mitophagy regulation of the inflammasome, or vice versa, is crucial for various biological functions, such as controlling inflammation and metabolism, immune and anti-tumor responses, and pyroptotic cell death. Uncontrolled regulation of the inflammasome often results in pathological inflammation and pyroptosis, and causes a variety of human diseases, including metabolic and inflammatory diseases, infection, and cancer. Here, we discuss how improved understanding of the interactions between inflammasome and mitophagy can lead to novel therapies against various disease pathologies, and how the inflammasome-mitophagy connection is currently being targeted pharmacologically by diverse agents and small molecules. A deeper understanding of the inflammasome-mitophagy connection will provide new insights into human health and disease through the balance between mitochondrial clearance and pathology.
Identifiants
pubmed: 32630319
pii: ijms21134714
doi: 10.3390/ijms21134714
pmc: PMC7370205
pii:
doi:
Substances chimiques
Inflammasomes
0
Interleukin-1beta
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2017R1A5A2015385
Organisme : National Research Foundation of Korea
ID : 2015K2A2A6002008
Organisme : Chungnam National University Hospital
ID : 2019
Références
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32342103
EMBO Rep. 2014 May;15(5):566-75
pubmed: 24671035
EMBO J. 2019 May 15;38(10):
pubmed: 30902848
Oxid Med Cell Longev. 2018 Sep 4;2018:9286458
pubmed: 30254716
Front Immunol. 2018 Nov 20;9:2633
pubmed: 30515154
Cell. 2016 Feb 25;164(5):896-910
pubmed: 26919428
Immunol Rev. 2009 Jan;227(1):106-28
pubmed: 19120480
PLoS Pathog. 2013;9(6):e1003400
pubmed: 23762026
Cells. 2019 Apr 08;8(4):
pubmed: 30965677
CNS Neurosci Ther. 2014 Dec;20(12):1045-55
pubmed: 25230377
Free Radic Biol Med. 2016 Nov;100:210-222
pubmed: 27094585
Mol Immunol. 2017 Jun;86:56-64
pubmed: 28169000
Cell Metab. 2017 Jul 5;26(1):71-93
pubmed: 28683296
Int J Mol Sci. 2017 Apr 28;18(5):
pubmed: 28452964
Oxid Med Cell Longev. 2019 Nov 25;2019:3836186
pubmed: 31885786
PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3178
pubmed: 25232720
Oxid Med Cell Longev. 2019 Feb 24;2019:8639618
pubmed: 30918581
Immunol Rev. 2017 May;277(1):61-75
pubmed: 28462526
Nat Immunol. 2015 May;16(5):458-66
pubmed: 25799126
Nature. 2012 Jan 18;481(7381):278-86
pubmed: 22258606
Cell Res. 2016 Dec;26(12):1273-1287
pubmed: 27857054
FASEB J. 2020 Feb;34(2):2821-2839
pubmed: 31908018
Mucosal Immunol. 2020 May;13(3):530-544
pubmed: 31953493
Int J Mol Sci. 2020 Mar 05;21(5):
pubmed: 32150829
Glia. 2019 May;67(5):802-824
pubmed: 30582668
Autophagy. 2016 Dec;12(12):2374-2385
pubmed: 27754761
Oxid Med Cell Longev. 2018 Jan 18;2018:8602041
pubmed: 29576856
J Cell Commun Signal. 2019 Sep;13(3):303-318
pubmed: 30719617
Mediators Inflamm. 2019 Jan 8;2019:2471215
pubmed: 30728749
J Leukoc Biol. 2017 Jan;101(1):205-215
pubmed: 27256568
Autophagy. 2020 Jan;16(1):3-17
pubmed: 30951392
Immunology. 2017 Oct;152(2):207-217
pubmed: 28695629
Sci Rep. 2017 May 25;7(1):2417
pubmed: 28546552
Nature. 2009 Mar 26;458(7237):509-13
pubmed: 19158676
Dev Cell. 2018 Aug 20;46(4):441-455.e8
pubmed: 30100261
Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F396-F407
pubmed: 30539655
Curr Opin Immunol. 2020 Feb;62:39-44
pubmed: 31837596
Science. 2015 Oct 23;350(6259):404-9
pubmed: 26449474
Immunol Rev. 2020 Mar;294(1):48-62
pubmed: 31944344
Autophagy. 2015 Apr 3;11(4):643-52
pubmed: 25919711
Redox Biol. 2019 Sep;26:101254
pubmed: 31229841
J Biol Chem. 2017 Feb 17;292(7):2916-2923
pubmed: 28062576
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17254-9
pubmed: 25404286
Mol Cells. 2020 Jan 31;43(1):10-22
pubmed: 31999918
Semin Cancer Biol. 2017 Dec;47:110-124
pubmed: 28450176
Mol Immunol. 2019 Jan;105:76-85
pubmed: 30496979
Nat Commun. 2014;5:3209
pubmed: 24492532
Cell Host Microbe. 2010 May 20;7(5):412-9
pubmed: 20417169
Ann Clin Lab Sci. 2017 May;47(3):243-252
pubmed: 28667023
Autophagy. 2016 Aug 2;12(8):1272-91
pubmed: 27337507
Cell Death Differ. 2009 Jul;16(7):939-46
pubmed: 19229244
Int J Mol Sci. 2015 Dec 30;17(1):
pubmed: 26729102
Hepatology. 2019 Feb;69(2):604-621
pubmed: 30053328
J Leukoc Biol. 2020 Jun 12;:
pubmed: 32531834
Cell Death Dis. 2019 Feb 12;10(2):128
pubmed: 30755589
Immunity. 2013 Aug 22;39(2):311-323
pubmed: 23954133
Cell Death Differ. 2013 Jan;20(1):31-42
pubmed: 22743996
Microbiol Mol Biol Rev. 2018 Sep 12;82(4):
pubmed: 30209070
Genes Chromosomes Cancer. 1998 Mar;21(3):230-5
pubmed: 9523198
Front Microbiol. 2016 Mar 31;7:456
pubmed: 27066000
Front Immunol. 2020 Apr 23;11:724
pubmed: 32391019
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90
pubmed: 25840011
Antioxid Redox Signal. 2015 May 1;22(13):1111-29
pubmed: 25330206
Inflammation. 2018 Oct;41(5):1590-1600
pubmed: 29959626
Mitochondrion. 2018 Jul;41:2-8
pubmed: 29107116
Nat Commun. 2015 Apr 14;6:6656
pubmed: 25871545
J Cell Mol Med. 2020 Mar;24(5):2832-2846
pubmed: 31975558
Cell. 2017 Jan 12;168(1-2):224-238.e10
pubmed: 28017329
Cell Res. 2020 Apr;30(4):315-327
pubmed: 32152420
Biochem Pharmacol. 2020 Jul;177:113997
pubmed: 32353422
Curr Pharm Des. 2020;26(4):485-491
pubmed: 31914907
Mol Cell. 2014 May 8;54(3):362-77
pubmed: 24746696
Mol Med. 2017 Sep;23:188-195
pubmed: 28741645
Nat Commun. 2018 Oct 12;9(1):4246
pubmed: 30315268
Nat Cell Biol. 2012 Jan 22;14(2):177-85
pubmed: 22267086
Trends Cell Biol. 2016 Jan;26(1):6-16
pubmed: 26437584
Nat Immunol. 2010 May;11(5):395-402
pubmed: 20351692
Cells. 2019 Jul 16;8(7):
pubmed: 31315173
J Neuroinflammation. 2019 Dec 9;16(1):260
pubmed: 31815636
Int Immunopharmacol. 2019 Aug;73:312-320
pubmed: 31129418
Autophagy. 2016 Dec;12(12):2386-2403
pubmed: 27764541
Pharmacol Ther. 2018 Jul;187:133-149
pubmed: 29466702
Mol Cell. 2015 Oct 1;60(1):7-20
pubmed: 26365381
Exp Cell Res. 2016 Feb 1;341(1):42-53
pubmed: 26825654
Antioxid Redox Signal. 2012 Sep 1;17(5):794-802
pubmed: 22077334
J Neuroimmune Pharmacol. 2017 Jun;12(2):233-248
pubmed: 27726055
J Electromyogr Kinesiol. 1992;2(4):242-51
pubmed: 20719617
Autophagy. 2020 Mar;16(3):419-434
pubmed: 31177901
Autophagy. 2018;14(9):1596-1619
pubmed: 29966509
Protein Cell. 2013 Jan;4(1):27-39
pubmed: 22996173
Oxid Med Cell Longev. 2018 Feb 13;2018:3537609
pubmed: 29636842
EMBO Rep. 2017 Jun;18(6):947-961
pubmed: 28381481
Trends Cell Biol. 2016 Oct;26(10):733-744
pubmed: 27291334
J Am Soc Nephrol. 2017 May;28(5):1437-1449
pubmed: 27881606
Cell Mol Immunol. 2016 Mar;13(2):148-59
pubmed: 26549800
Behav Brain Res. 2016 Oct 15;313:334-344
pubmed: 27424778
Autophagy. 2014 Oct 1;10(10):1712-25
pubmed: 25126723
Immune Netw. 2017 Apr;17(2):77-88
pubmed: 28458619
Front Cell Dev Biol. 2017 Sep 29;5:90
pubmed: 29034233
Redox Biol. 2020 Jan;28:101363
pubmed: 31707353
Am J Pathol. 2017 Dec;187(12):2659-2673
pubmed: 28935571
Curr Opin Cell Biol. 2015 Apr;33:95-101
pubmed: 25697963
Biochimie. 2009 Jun;91(6):779-83
pubmed: 19254751
Biol Chem. 2016 Jul 1;397(7):637-47
pubmed: 27145142
Nat Immunol. 2010 May;11(5):385-93
pubmed: 20351693
FEBS J. 2018 Apr;285(7):1185-1202
pubmed: 29151277
J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6
pubmed: 29778503
Sci Rep. 2019 Jul 31;9(1):11128
pubmed: 31366948
Hum Mol Genet. 2016 Aug 15;25(16):3476-3490
pubmed: 27334109
Methods Enzymol. 2019;625:177-204
pubmed: 31455527
Am J Respir Cell Mol Biol. 2016 Feb;54(2):151-60
pubmed: 26418144
Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):110-20
pubmed: 23221073
Semin Immunopathol. 2017 Feb;39(2):215-223
pubmed: 27405866
J Cell Physiol. 2020 Apr;235(4):3207-3221
pubmed: 31621910
Nature. 2009 Mar 26;458(7237):514-8
pubmed: 19158675
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19500-5
pubmed: 18048346
Cell Res. 2015 Dec;25(12):1285-98
pubmed: 26611636
Mol Immunol. 2018 Nov;103:115-124
pubmed: 30248487
Gastroenterology. 2018 Apr;154(5):1449-1464.e20
pubmed: 29277561
Int Immunol. 2017 May 1;29(5):201-210
pubmed: 28531279
Nat Rev Immunol. 2010 Mar;10(3):210-5
pubmed: 20168318
Cell. 2013 Apr 11;153(2):348-61
pubmed: 23582325
J Immunol. 2013 Oct 15;191(8):4358-66
pubmed: 24048902
Immunol Rev. 2015 May;265(1):130-42
pubmed: 25879289
Biol Chem. 2012 Jul;393(7):547-64
pubmed: 22944659
Aging Cell. 2017 Oct;16(5):943-955
pubmed: 28758328
Adv Exp Med Biol. 2019;1172:143-155
pubmed: 31628655
Eur J Immunol. 2020 Feb;50(2):170-177
pubmed: 31411729
Mediators Inflamm. 2015;2015:794143
pubmed: 26576076
Nat Immunol. 2016 Mar;17(3):250-8
pubmed: 26642356
Science. 2009 Feb 20;323(5917):1057-60
pubmed: 19131592
Curr Opin Crit Care. 2017 Aug;23(4):284-290
pubmed: 28562385
Cell Res. 2014 Jul;24(7):787-95
pubmed: 24903109
Eur J Immunol. 2011 May;41(5):1196-202
pubmed: 21469137
Curr Opin Cell Biol. 2017 Apr;45:83-91
pubmed: 28437683
Brain Res. 2019 May 1;1710:163-172
pubmed: 30615886
Sci Transl Med. 2011 May 11;3(82):82ra38
pubmed: 21562230
iScience. 2019 Jun 28;16:468-484
pubmed: 31229895
J Am Coll Cardiol. 2019 Mar 19;73(10):1149-1169
pubmed: 30871699
Brain Behav Immun. 2019 Oct;81:509-522
pubmed: 31288070
Cells. 2019 Aug 14;8(8):
pubmed: 31416289
Oxid Med Cell Longev. 2016;2016:1987149
pubmed: 26770647
Genome Res. 2010 Feb;20(2):170-9
pubmed: 20028698
Autophagy. 2014 Feb;10(2):376-8
pubmed: 24351649
Redox Biol. 2014;3:63-71
pubmed: 25462067
Inflamm Res. 2020 Feb;69(2):159-166
pubmed: 31932850
Nature. 2015 Oct 29;526(7575):660-5
pubmed: 26375003
Mol Cell. 2009 May 15;34(3):259-69
pubmed: 19450525
Lab Invest. 2019 Jun;99(6):749-763
pubmed: 30700851
Science. 2015 Oct 23;350(6259):399-404
pubmed: 26449475
J Biol Chem. 2016 Jan 1;291(1):103-9
pubmed: 26553871
Nat Med. 2013 Aug;19(8):1039-46
pubmed: 23852339
Curr Top Microbiol Immunol. 2016;397:215-27
pubmed: 27460812
Immunity. 2015 Aug 18;43(2):331-42
pubmed: 26253785
Nat Immunol. 2013 May;14(5):480-8
pubmed: 23525089
Biochem Pharmacol. 2018 Sep;155:366-379
pubmed: 30012462
Autophagy. 2014 Jun;10(6):972-85
pubmed: 24879148
Autophagy. 2015;11(1):166-82
pubmed: 25700738
Essays Biochem. 2017 Dec 12;61(6):609-624
pubmed: 29233872
Mol Cell. 2019 Oct 17;76(2):268-285
pubmed: 31585693
Int J Mol Sci. 2019 Jul 06;20(13):
pubmed: 31284572
Immunol Rev. 2015 May;265(1):35-52
pubmed: 25879282
Nature. 2015 Aug 20;524(7565):309-314
pubmed: 26266977
Nat Cell Biol. 2013 Oct;15(10):1197-1205
pubmed: 24036476
Biochem Pharmacol. 2020 Feb;172:113773
pubmed: 31866303
Physiol Rev. 2019 Jan 1;99(1):853-892
pubmed: 30540226
Annu Rev Physiol. 2017 Feb 10;79:471-494
pubmed: 28192059
J Neurosci. 2017 Mar 29;37(13):3599-3609
pubmed: 28270571
BMB Rep. 2016 Oct;49(10):529-535
pubmed: 27439607
Nat Commun. 2019 May 3;10(1):2059
pubmed: 31053718
Nature. 2011 Jan 13;469(7329):221-5
pubmed: 21124315
Nat Rev Immunol. 2016 Jul;16(7):407-20
pubmed: 27291964
Nature. 2016 Feb 18;530(7590):354-7
pubmed: 26814970
Commun Biol. 2019 Oct 3;2:353
pubmed: 31602405
Cell Metab. 2019 Jun 4;29(6):1350-1362.e7
pubmed: 30982734
J Immunol. 2013 Apr 1;190(7):3517-24
pubmed: 23427251
J Korean Med Sci. 2013 Oct;28(10):1415-23
pubmed: 24133343
Curr Opin Microbiol. 2020 Apr;54:77-86
pubmed: 32120337
Cell Mol Life Sci. 2016 Feb;73(4):775-95
pubmed: 26611876
Nature. 2008 Jul 10;454(7201):232-5
pubmed: 18454133
Nat Immunol. 2009 Mar;10(3):266-72
pubmed: 19158679
Autophagy. 2018;14(5):915-917
pubmed: 28614042
DNA Cell Biol. 2019 Jan;38(1):10-22
pubmed: 30556744
PLoS Pathog. 2017 Oct 19;13(10):e1006644
pubmed: 29049365
Front Neurosci. 2019 Oct 10;13:1065
pubmed: 31649499
Eur J Pharmacol. 2019 Dec 1;864:172715
pubmed: 31593687
Cell Signal. 2014 Dec;26(12):2921-9
pubmed: 25224329
J Biol Chem. 2013 Jan 4;288(1):111-21
pubmed: 23150663
Mol Aspects Med. 2020 Jun 1;:100863
pubmed: 32499055
Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):12-6
pubmed: 27586797
Cell. 2015 Jul 2;162(1):45-58
pubmed: 26095253
Immunology. 2019 Nov;158(3):240-251
pubmed: 31429483
Arch Pharm Res. 2016 Nov;39(11):1503-1518
pubmed: 27600432