Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats.
CMPI
acute thermal nociception
desformylflustrabromine (dFBr)
hot plate
nicotinic acetylcholine receptors (nAChRs)
positive allosteric modulators (PAMs)
tail flick
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Jun 2020
25 Jun 2020
Historique:
received:
04
06
2020
revised:
19
06
2020
accepted:
22
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
27
3
2021
Statut:
epublish
Résumé
Neuronal nicotinic acetylcholine receptor (nAChR)-based therapeutics are sought as a potential alternative strategy to opioids for pain management. In this study, we examine the antinociceptive effects of 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1
Identifiants
pubmed: 32630476
pii: molecules25122923
doi: 10.3390/molecules25122923
pmc: PMC7355939
pii:
doi:
Substances chimiques
Hydrocarbons, Brominated
0
Isoxazoles
0
Nicotinic Agonists
0
Pyrazoles
0
Receptors, Nicotinic
0
nicotinic receptor alpha4beta2
0
pyrazole
3QD5KJZ7ZJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R25 GM090084
Pays : United States
Références
Molecules. 2019 Mar 07;24(5):
pubmed: 30866543
J Pharmacol Exp Ther. 2015 Aug;354(2):184-94
pubmed: 26025967
Eur J Pharmacol. 2013 Jul 15;712(1-3):22-9
pubmed: 23660369
Front Behav Neurosci. 2017 Jan 05;10:244
pubmed: 28105008
Eur J Pharmacol. 2005 Feb 10;509(1):43-8
pubmed: 15713428
Biochem Pharmacol. 2011 Oct 15;82(8):967-76
pubmed: 21620806
Mol Pharmacol. 2017 Sep;92(3):327-337
pubmed: 28698187
Life Sci. 1980 Apr 14;26(15):1247-59
pubmed: 7392798
Biochem Pharmacol. 2018 May;151:214-225
pubmed: 29248596
J Biol Chem. 2014 Sep 5;289(36):24911-21
pubmed: 24982426
Biochem Pharmacol. 2009 Oct 1;78(7):703-11
pubmed: 19481063
J Biol Chem. 2017 Jun 16;292(24):9988-10001
pubmed: 28446611
Psychopharmacology (Berl). 2013 Nov;230(2):203-13
pubmed: 23712602
Mol Pharmacol. 2015 Jul;88(1):1-11
pubmed: 25870334
Nicotine Tob Res. 2018 Jun 7;20(7):903-907
pubmed: 29059422
Pharmacol Ther. 2013 Jan;137(1):22-54
pubmed: 22925690
Pain. 2000 May;86(1-2):113-8
pubmed: 10779668
J Pharmacol Toxicol Methods. 1995 Sep;34(1):23-7
pubmed: 7496043
Br J Pharmacol. 2010 Mar;159(6):1201-10
pubmed: 20136830
J Biol Chem. 2017 Jan 13;292(2):551-562
pubmed: 27864368
Curr Top Med Chem. 2004;4(3):369-84
pubmed: 14754452
Eur J Pharmacol. 2016 Sep 5;786:169-178
pubmed: 27238974
Bioorg Med Chem Lett. 2008 Oct 1;18(19):5209-12
pubmed: 18789861
Nature. 1999 Apr 29;398(6730):805-10
pubmed: 10235262
Biochem Pharmacol. 2011 Oct 15;82(8):952-8
pubmed: 21596025
Curr Pharm Des. 2016;22(14):1986-97
pubmed: 26831463
Sci Rep. 2018 Jan 19;8(1):1249
pubmed: 29352227
Neurosci Lett. 2005 Jan 10;373(2):144-9
pubmed: 15567570
Trends Pharmacol Sci. 2015 Feb;36(2):96-108
pubmed: 25639674
Future Med Chem. 2018 Feb 1;10(4):433-459
pubmed: 29451400
Nicotine Tob Res. 2017 Apr 1;19(4):460-468
pubmed: 27639096
Front Mol Neurosci. 2015 Nov 25;8:71
pubmed: 26635524
Br J Pharmacol. 2013 Jun;169(3):567-79
pubmed: 23004024
Science. 1998 Jan 2;279(5347):77-81
pubmed: 9417028
Curr Opin Investig Drugs. 2004 Jan;5(1):76-81
pubmed: 14983978
Biochem Pharmacol. 2013 Oct 15;86(8):1208-14
pubmed: 23948066
Neuropharmacology. 2015 Sep;96(Pt B):302-11
pubmed: 25460185
Brain Res. 2012 Jun 6;1458:67-75
pubmed: 22552114
Biochem Pharmacol. 2011 Oct 15;82(8):959-66
pubmed: 21763685
Eur J Pain. 2018 Jan;22(1):84-93
pubmed: 28809075
Mol Pharmacol. 2016 May;89(5):575-84
pubmed: 26976945
Neuropharmacology. 2020 May 15;168:108008
pubmed: 32113032
Biochem Pharmacol. 2011 Oct 15;82(8):915-30
pubmed: 21575610