Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia.
Toll-like receptor 3
Toll-like receptor 9
brain macrophage
costimulation
glioma
microglia
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
12 08 2020
12 08 2020
Historique:
received:
23
03
2020
revised:
28
05
2020
accepted:
05
06
2020
pubmed:
8
7
2020
medline:
5
1
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
In murine experimental glioma models, TLR3 or TLR9 activation of microglial/macrophages has been shown to impair glioma growth, which could, however, not been verified in recent clinical trials. We therefore tested whether combined TLR3 and TLR9 activation of microglia/macrophages would have a synergistic effect. Indeed, combined TLR3/TLR9 activation augmented the suppression of glioma growth in organotypic brain slices from male mice in a microglia-dependent fashion, and this synergistic suppression depended on interferon β release and phagocytic tumor clearance. Combined TLR3/TLR9 stimulation also augmented several functional features of microglia, such as the release of proinflammatory factors, motility, and phagocytosis activity. TLR3/TLR9 stimulation combined with CD47 blockade further augmented glioma clearance. Finally, we confirmed that the coactivation of TLR3/TLR9 also augments the impairment of glioma growth
Identifiants
pubmed: 32631940
pii: JNEUROSCI.0666-20.2020
doi: 10.1523/JNEUROSCI.0666-20.2020
pmc: PMC7424875
doi:
Substances chimiques
Inflammation Mediators
0
TLR3 protein, mouse
0
Tlr9 protein, mouse
0
Toll-Like Receptor 3
0
Toll-Like Receptor 9
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6428-6443Informations de copyright
Copyright © 2020 the authors.
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