Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons.
Animals
Basal Ganglia
/ physiology
Behavior, Animal
/ physiology
Impulsive Behavior
/ physiology
Inhibition, Psychological
Interneurons
/ physiology
Mice
Neurons
/ physiology
Optogenetics
Prefrontal Cortex
/ diagnostic imaging
Pyramidal Cells
/ pathology
Subthalamic Nucleus
/ diagnostic imaging
Visual Cortex
impulsive behavior
lateral hypothalamus
prefrontal cortex
subthalamic nucleus
two-photon calcium imaging
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 07 2020
21 07 2020
Historique:
pubmed:
8
7
2020
medline:
15
9
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the underlying circuit mechanism remains incompletely understood. Here we show that a subset of dorsomedial PFC (dmPFC) layer 5 pyramidal neurons, which project to the subthalamic nucleus (STN) of the basal ganglia, play a key role in inhibiting impulsive responses in a go/no-go task. Projection-specific labeling and calcium imaging showed that the great majority of STN-projecting neurons were preferentially active in no-go trials when the mouse successfully withheld licking responses, but lateral hypothalamus (LH)-projecting neurons were more active in go trials with licking; visual cortex (V1)-projecting neurons showed only weak task-related activity. Optogenetic activation and inactivation of STN-projecting neurons reduced and increased inappropriate licking, respectively, partly through their direct innervation of the STN, but manipulating LH-projecting neurons had the opposite effects. These results identify a projection-defined subtype of PFC pyramidal neurons as key mediators of impulse control.
Identifiants
pubmed: 32631999
pii: 2000523117
doi: 10.1073/pnas.2000523117
pmc: PMC7382266
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17278-17287Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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