Predictive factors for irreversible motor paralysis following cervical spinal cord injury.
Journal
Spinal cord
ISSN: 1476-5624
Titre abrégé: Spinal Cord
Pays: England
ID NLM: 9609749
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
30
08
2019
accepted:
25
06
2020
revised:
24
06
2020
pubmed:
8
7
2020
medline:
16
10
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
A retrospective observational study. To elucidate predictive clinical factors associated with irreversible complete motor paralysis following traumatic cervical spinal cord injury (CSCI). Hokkaido Spinal Cord Injury Center, Japan. A consecutive series of 447 traumatic CSCI persons were eligible for this study. Individuals with complete motor paralysis at admission were selected and divided into two groups according to the motor functional outcomes at discharge. Initial findings in magnetic resonance imaging (MRI) and other clinical factors that could affect functional outcomes were compared between two groups of participants: those with and those without motor recovery below the level of injury at the time of discharge. Of the 73 consecutive participants with total motor paralysis at initial examination, 28 showed some recovery of motor function, whereas 45 remained complete motor paralysis at discharge, respectively. Multivariate logistic regression analysis showed that the presence of intramedullary hemorrhage manifested as a confined low intensity changes in diffuse high-intensity area and more than 50% of cord compression on MRI were significant predictors of irreversible complete motor paralysis (odds ratio [OR]: 8.4; 95% confidence interval [CI]: 1.2-58.2 and OR: 14.4; 95% CI: 2.5-82.8, respectively). The presence of intramedullary hemorrhage and/or severe cord compression on initial MRI were closely associated with irreversible paralysis in persons with motor complete paralysis following CSCI. Conversely, subjects with a negligible potential for recovery could be identified by referring to these negative findings.
Identifiants
pubmed: 32632174
doi: 10.1038/s41393-020-0513-8
pii: 10.1038/s41393-020-0513-8
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
554-562Références
Kitamura K, Iwanami A, Iwai H, Toyama Y, Matsumoto M, Okano H, et al. TherapeuTic Time Window And Preclinical Efficacy Of Intrathecal Administration Of Recombinant Human Hepatocyte Growth Factor For Acute Spinal Cord Injury. J Spine Res: Off J Jpn Soc Spine Surg Relat Res. 2016;5:934–9.
Kitamura K, Nagoshi N, Tsuji O, Matsumoto M, Okano H, Nakamura M. Application of hepatocyte growth factor for acute spinal cord injury: the road from basic studies to human treatment. Int J Mol Sci. 2019;20:1054.
Fehlings MG, Nakashima H, Nagoshi N, Chow DS, Grossman RG, Kopjar B. Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial. Spinal Cord. 2016;54:8–15.
pubmed: 26099215
doi: 10.1038/sc.2015.95
pmcid: 26099215
Casha S, Zygun D, McGowan MD, Bains I, Yong VW, Hurlbert RJ. Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain. 2012;135(Pt 4):1224–36.
pubmed: 22505632
pmcid: 22505632
doi: 10.1093/brain/aws072
Nagoshi N, Nakashima H, Fehlings MG. Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside. Molecules. 2015;20:7775–89.
pubmed: 25939067
pmcid: 6272473
doi: 10.3390/molecules20057775
Fehlings MG, Theodore N, Harrop J, Maurais G, Kuntz C, Shaffrey CI, et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011;28:787–96.
pubmed: 21381984
doi: 10.1089/neu.2011.1765
pmcid: 21381984
Geisler FH, Coleman WP, Grieco G, Poonian D, Sygen Study G. The Sygen multicenter acute spinal cord injury study. Spine (Philos Pa 1976). 2001;26(24 Suppl):S87–98.
doi: 10.1097/00007632-200112151-00015
Tuszynski MH, Steeves JD, Fawcett JW, Lammertse D, Kalichman M, Rask C, et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord. 2007;45:222–31.
pubmed: 17179971
doi: 10.1038/sj.sc.3102009
pmcid: 17179971
Lammertse D, Tuszynski MH, Steeves JD, Curt A, Fawcett JW, Rask C, et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord. 2007;45:232–42.
pubmed: 17179970
doi: 10.1038/sj.sc.3102010
pmcid: 17179970
Maynard FM Jr., Bracken MB, Creasey G, Ditunno JF Jr., Donovan WH, Ducker TB, et al. International Standards for Neurological and Functional Classification of Spinal Cord Injury. American Spinal Injury Association. Spinal Cord. 1997;35:266–74.
pubmed: 9160449
doi: 10.1038/sj.sc.3100432
Kirshblum SC, Burns SP, Biering-Sorensen F, Donovan W, Graves DE, Jha A, et al. International standards for neurological classification of spinal cord injury (revised 2011). J Spinal Cord Med. 2011;34:535–46.
pubmed: 22330108
pmcid: 3232636
doi: 10.1179/204577211X13207446293695
Scivoletto G, Tamburella F, Laurenza L, Torre M, Molinari M. Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury. Front Hum Neurosci. 2014;8:141.
pubmed: 24659962
pmcid: 3952432
doi: 10.3389/fnhum.2014.00141
Burns AS, Marino RJ, Flanders AE, Flett H. Clinical diagnosis and prognosis following spinal cord injury. Handb Clin Neurol. 2012;109:47–62.
pubmed: 23098705
doi: 10.1016/B978-0-444-52137-8.00003-6
Marino RJ, Ditunno JF,Jr., Donovan WH, Maynard F,Jr. Neurologic recovery after traumatic spinal cord injury: data from the Model Spinal Cord Injury Systems. Arch Phys Med Rehabil. 1999;80:1391–6.
pubmed: 10569432
doi: 10.1016/S0003-9993(99)90249-6
Scivoletto G, Morganti B, Molinari M. Neurologic recovery of spinal cord injury patients in Italy. Arch Phys Med Rehabil. 2004;85:485–9.
pubmed: 15031838
doi: 10.1016/S0003-9993(03)00766-4
Burns AS, Lee BS, Ditunno JF Jr., Tessler A. Patient selection for clinical trials: the reliability of the early spinal cord injury examination. J Neurotrauma. 2003;20:477–82.
pubmed: 12803979
doi: 10.1089/089771503765355540
Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski MH, Lammertse D, et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord. 2007;45:190–205.
pubmed: 17179973
doi: 10.1038/sj.sc.3102007
Song PW, Dong FL, Feng CC, Shen YN, Wang Y, Zhang RJ, et al. A study of predictors for hyponatraemia in patients with cervical spinal cord injury. Spinal Cord. 2018;56:84–89.
pubmed: 28895577
doi: 10.1038/sc.2017.103
Yugue I, Okada S, Ueta T, Maeda T, Mori E, Kawano O, et al. Analysis of the risk factors for tracheostomy in traumatic cervical spinal cord injury. Spine (Philos Pa 1976). 2012;37:E1633–8.
doi: 10.1097/BRS.0b013e31827417f1
Cadotte DW, Wilson JR, Mikulis D, Stroman PW, Brady S, Fehlings MG. Conventional MRI as a diagnostic and prognostic tool in spinal cord injury: a systemic review of its application to date and an overview on emerging MRI methods. Expert Opin Med diagnostics. 2011;5:121–33.
doi: 10.1517/17530059.2011.556111
Ditunno J, Little J, Tessler A, Burns A. Spinal shock revisited: a four-phase model. Spinal cord. 2004;42:383.
pubmed: 15037862
doi: 10.1038/sj.sc.3101603
Waring WP 3rd, Biering-Sorensen F, Burns S, Donovan W, Graves D, Jha A, et al. review and revisions of the international standards for the neurological classification of spinal cord injury. J Spinal Cord Med. 2010;33:346–52. 2009.
pubmed: 21061894
pmcid: 2964022
doi: 10.1080/10790268.2010.11689712
Lucas JT, Ducker TB. Motor classification of spinal cord injuries with mobility, morbidity and recovery indices. Am Surg. 1979;45:151–8.
pubmed: 434614
Flanders AE, Spettell CM, Tartaglino LM, Friedman DP, Herbison GJ. Forecasting motor recovery after cervical spinal cord injury: value of MR imaging. Radiology. 1996;201:649–55.
pubmed: 8939210
doi: 10.1148/radiology.201.3.8939210
Kawano O, Ueta T, Shiba K, Iwamoto Y. Outcome of decompression surgery for cervical spinal cord injury without bone and disc injury in patients with spinal cord compression: a multicenter prospective study. Spinal Cord. 2010;48:548–53.
pubmed: 20065985
doi: 10.1038/sc.2009.179
Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology. 1976;119:559–68.
pubmed: 935390
doi: 10.1148/119.3.559
Vaccaro AR, Koerner JD, Radcliff KE, Oner FC, Reinhold M, Schnake KJ, et al. AOSpine subaxial cervical spine injury classification system. Eur Spine J. 2016;25:2173–84.
pubmed: 25716661
doi: 10.1007/s00586-015-3831-3
Gupta SK, Rajeev K, Khosla VK, Sharma BS, Paramjit, Mathuriya SN, et al. Spinal cord injury without radiographic abnormality in adults. Spinal Cord. 1999;37:726–9.
pubmed: 10557129
doi: 10.1038/sj.sc.3100900
Machino M, Yukawa Y, Ito K, Nakashima H, Kanbara S, Morita D, et al. Can magnetic resonance imaging reflect the prognosis in patients of cervical spinal cord injury without radiographic abnormality? Spine (Philos Pa 1976). 2011;36:E1568–72.
doi: 10.1097/BRS.0b013e31821273c0
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl. 2013;48:452–8.
doi: 10.1038/bmt.2012.244
Matsushita A, Maeda T, Mori E, Yugue I, Kawano O, Ueta T, et al. Subacute T1-low intensity area reflects neurological prognosis for patients with cervical spinal cord injury without major bone injury. Spinal Cord. 2016;54:24–8.
pubmed: 26078230
doi: 10.1038/sc.2015.84
pmcid: 26078230
Mahmood NS, Kadavigere R, Avinash KR, Rao VR. Magnetic resonance imaging in acute cervical spinal cord injury: a correlative study on spinal cord changes and 1 month motor recovery. Spinal Cord. 2008;46:791–7.
pubmed: 18542094
doi: 10.1038/sc.2008.55
pmcid: 18542094
Pan G, Kulkarni M, MacDougall DJ, Miner ME. Traumatic epidural hematoma of the cervical spine: diagnosis with magnetic resonance imaging. Case report. J Neurosurg. 1988;68:798–801.
pubmed: 3357037
doi: 10.3171/jns.1988.68.5.0798
pmcid: 3357037
Bozzo A, Marcoux J, Radhakrishna M, Pelletier J, Goulet B. The role of magnetic resonance imaging in the management of acute spinal cord injury. J Neurotrauma. 2011;28:1401–11.
pubmed: 20388006
pmcid: 3143391
doi: 10.1089/neu.2009.1236
Schaefer DM, Flanders AE, Osterholm JL, Northrup BE. Prognostic significance of magnetic resonance imaging in the acute phase of cervical spine injury. J Neurosurg. 1992;76:218–23.
pubmed: 1730950
doi: 10.3171/jns.1992.76.2.0218
Selden NR, Quint DJ, Patel N, d’Arcy HS, Papadopoulos SM. Emergency magnetic resonance imaging of cervical spinal cord injuries: clinical correlation and prognosis. Neurosurgery. 1999;44:785–92. discussion 792-3.
pubmed: 10201304
doi: 10.1097/00006123-199904000-00057
Boldin C, Raith J, Fankhauser F, Haunschmid C, Schwantzer G, Schweighofer F. Predicting neurologic recovery in cervical spinal cord injury with postoperative MR imaging. Spine (Phila Pa 1976). 2006;31:554–9.
doi: 10.1097/01.brs.0000201274.59427.a4
Bondurant FJ, Cotler HB, Kulkarni MV, McArdle CB, Harris JH,Jr. Acute spinal cord injury. A study using physical examination and magnetic resonance imaging. Spine (Phila Pa 1976). 1990;15:161–8.
doi: 10.1097/00007632-199003000-00002
Ramon S, Dominguez R, Ramirez L, Paraira M, Olona M, Castello T, et al. Clinical and magnetic resonance imaging correlation in acute spinal cord injury. Spinal Cord. 1997;35:664–73.
pubmed: 9347595
doi: 10.1038/sj.sc.3100490
Shimada K, Tokioka T. Sequential MR studies of cervical cord injury: correlation with neurological damage and clinical outcome. Spinal Cord. 1999;37:410–5.
pubmed: 10432260
doi: 10.1038/sj.sc.3100858
Maeda T, Ueta T, Mori E, Yugue I, Kawano O, Takao T, et al. Soft-tissue damage and segmental instability in adult patients with cervical spinal cord injury without major bone injury. Spine (Philos Pa 1976). 2012;37:E1560–6.
doi: 10.1097/BRS.0b013e318272f345
Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, et al. Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Sci Transl Med. 2014;6:256ra137.
pubmed: 25273098
doi: 10.1126/scitranslmed.3009430
pmcid: 25273098
Burns SP, Golding DG, Rolle WA Jr., Graziani V, Ditunno JF Jr. Recovery of ambulation in motor-incomplete tetraplegia. Arch Phys Med Rehabil. 1997;78:1169–72.
pubmed: 9365343
doi: 10.1016/S0003-9993(97)90326-9
pmcid: 9365343
Scivoletto G, Morganti B, Ditunno P, Ditunno JF, Molinari M. Effects on age on spinal cord lesion patients’ rehabilitation. Spinal Cord. 2003;41:457–64.
pubmed: 12883544
doi: 10.1038/sj.sc.3101489
pmcid: 12883544
Newton D, England M, Doll H, Gardner BP. The case for early treatment of dislocations of the cervical spine with cord involvement sustained playing rugby. J Bone Jt Surg Br. 2011;93:1646–52.
doi: 10.1302/0301-620X.93B12.27048
Guest J, Eleraky MA, Apostolides PJ, Dickman CA, Sonntag VK. Traumatic central cord syndrome: results of surgical management. J Neurosurg. 2002;97 Suppl 1:25–32.
pubmed: 12120648
pmcid: 12120648
Tsuji O, Suda K, Takahata M, Matsumoto-Harmon S, Komatsu M, Menjo Y, et al. Early surgical intervention may facilitate recovery of cervical spinal cord injury in DISH. J Orthop Surg (Hong Kong). 2019;27:2309499019834783.
doi: 10.1177/2309499019834783
Fehlings MG, Vaccaro A, Wilson JR, Singh A, D WC, Harrop JS, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS ONE. 2012;7:e32037.
pubmed: 22384132
pmcid: 3285644
doi: 10.1371/journal.pone.0032037
Kawano O, Maeda T, Mori E, Takao T, Sakai H, Masuda M, et al. How much time is necessary to confirm the diagnosis of permanent complete cervical spinal cord injury? Spinal Cord. 2020;58:284–89.
Herbison GJ, Zerby SA, Cohen ME, Marino RJ, Ditunno JF Jr. Motor power differences within the first two weeks post-SCI in cervical spinal cord-injured quadriplegic subjects. J Neurotrauma. 1992;9:373–80.
pubmed: 1291696
doi: 10.1089/neu.1992.9.373
Waters RL, Adkins RH, Yakura JS, Sie I. Motor and sensory recovery following complete tetraplegia. Arch Phys Med Rehabil. 1993;74:242–7.
pubmed: 8439249
Waters RL, Adkins RH, Yakura JS, Sie I. Motor and sensory recovery following incomplete tetraplegia. Arch Phys Med Rehabil. 1994;75:306–11.
pubmed: 8129584
doi: 10.1016/0003-9993(94)90034-5
Eidelberg E, Walden JG, Nguyen LH. Locomotor control in macaque monkeys. Brain. 1981;104:647–63.
pubmed: 7326562
doi: 10.1093/brain/104.4.647-a
Fehlings MG, Tator CH. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp Neurol. 1995;132:220–8.
pubmed: 7789460
doi: 10.1016/0014-4886(95)90027-6
Raineteau O, Schwab ME. Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci. 2001;2:263–73.
pubmed: 11283749
doi: 10.1038/35067570
Windle WF, Smart JO, Beers JJ. Residual function after subtotal spinal cord transection in adult cats. Neurology. 1958;8:518–21.
pubmed: 13566395
doi: 10.1212/WNL.8.7.518
Iwanami A, Yamane J, Katoh H, Nakamura M, Momoshima S, Ishii H, et al. Establishment of graded spinal cord injury model in a nonhuman primate: the common marmoset. J Neurosci Res. 2005;80:172–81.
pubmed: 15772980
doi: 10.1002/jnr.20435
Hayakawa K, Okazaki R, Ishii K, Ueno T, Izawa N, Tanaka Y, et al. Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study. Spinal Cord. 2012;50:493–6.
pubmed: 22270191
doi: 10.1038/sc.2011.184
Kijima K, Kubota K, Hara M, Kobayakawa K, Yokota K, Saito T, et al. The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury. EBioMedicine. 2019;41:659–69.
pubmed: 30902739
pmcid: 6444130
doi: 10.1016/j.ebiom.2019.03.003
Konomi T, Fujiyoshi K, Hikishima K, Komaki Y, Tsuji O, Okano HJ, et al. Conditions for quantitative evaluation of injured spinal cord by in vivo diffusion tensor imaging and tractography: Preclinical longitudinal study in common marmosets. Neuroimage. 2012;63:1841–53.
pubmed: 22922169
doi: 10.1016/j.neuroimage.2012.08.040
Oleson CV, Burns AS, Ditunno JF, Geisler FH, Coleman WP. Prognostic value of pinprick preservation in motor complete, sensory incomplete spinal cord injury. Arch Phys Med Rehabil. 2005;86:988–92.
pubmed: 15895346
doi: 10.1016/j.apmr.2004.09.031