From the Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH-8092 Zurich, Switzerland (P.O.W., A.H.); Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland (P.O.W.); Max Planck Institute for Biological Cybernetics, Tuebingen, Germany (P.O.W., A.H.); Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland (E.H., A.C., P.F.); Institute of Neuroradiology, University Hospital, Zurich, Switzerland (S.K.); Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, England (P.F.); Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, England (P.F.); Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (P.F.); and Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany (A.H.).
From the Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH-8092 Zurich, Switzerland (P.O.W., A.H.); Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland (P.O.W.); Max Planck Institute for Biological Cybernetics, Tuebingen, Germany (P.O.W., A.H.); Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland (E.H., A.C., P.F.); Institute of Neuroradiology, University Hospital, Zurich, Switzerland (S.K.); Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, England (P.F.); Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, England (P.F.); Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (P.F.); and Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany (A.H.).
From the Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH-8092 Zurich, Switzerland (P.O.W., A.H.); Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland (P.O.W.); Max Planck Institute for Biological Cybernetics, Tuebingen, Germany (P.O.W., A.H.); Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland (E.H., A.C., P.F.); Institute of Neuroradiology, University Hospital, Zurich, Switzerland (S.K.); Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, England (P.F.); Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, England (P.F.); Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (P.F.); and Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany (A.H.).
Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
The primary aim of this study is to assess the viability of employing multimodal radiomics techniques for distinguishing between cervical spinal cord injury and spinal cord concussion in cervical magn...
To develop prospective motion correction for single-voxel MRS in the human cervical spinal cord....
A motion MR navigator was implemented using reduced field-of-view 2D-selective RF excitation together with EPI readout. A short-echo semi-LASER sequence (T...
Without prospective correction, motion resulted in severe lipid contamination in the MR spectra. With prospective correction, the quality of spinal cord MR spectra in the presence of motion was simila...
Prospective motion and B...
Spinal cord malignant melanotic schwannoma (MMNST) is a rare central nervous system tumor that originates from the spinal cord or spinal myelin sheath cells and can produce melanin. This type of tumor...
A narrative review....
To summarize relevant data from representative studies investigating upper limb restorative therapies for cervical spinal cord injury....
Cervical spinal cord injury (SCI) is a debilitating condition resulting in tetraplegia, lifelong disability, and reduced quality of life. Given the dependence of all activities on hand function, patie...
In this article, a narrative literature review was performed to identify treatment options targeting the restoration of function in patients with cervical SCI. Studies were included from available lit...
We describe relevant studies including indications and outcomes with a focus on arm and hand function. Different treatment modalities described include nerve transfers, tendon transfers, spinal cord s...
While complete recovery from cervical spinal cord injury may not be possible, novel therapies aimed at the restoration of upper limb motor function have made significant progress toward the realizatio...
Spinal cord injury (SCI) causes drastic changes to an individual's physical health that may be associated with the ability to work....
To estimate the association of SCI with individual earnings and employment status using national administrative health databases linked to income tax data....
This was a retrospective, national, population-based cohort study of adults who were hospitalized with cervical SCI in Canada between January 2005 and December 2017. All acute care hospitalizations fo...
The first outcome was the change in individual annual earnings up to 5 years after injury. The change in mean yearly earnings was assessed using a linear mixed-effects differences-in-differences regre...
A total of 1630 patients with SCI (mean [SD] age, 47 [13] years; 1304 male [80.0%]) were matched to patients in a preinjury comparison group (resampled from the same 1630 patients in the SCI group). T...
In this study, SCI was associated with a decline in earnings and employment up to 5 years after injury for adults aged 18 to 64 years in Canada....
Following spinal cord injury (SCI), gait function reaches a post-recovery plateau that depends on the paralysis severity. However, the plateau dynamics during the recovery period are not known. This s...
This retrospective cohort study included 122 patients with traumatic CSCI admitted to a single specialized facility within 2 weeks after injury. The Walking Index for Spinal Cord Injury II (WISCI II) ...
In the AIS grade A and B groups, no significant differences were observed at any time point, while in the AIS grade C group, the mean WISCI II values continued to significantly increase up to 6 months...
The plateau in gait function recovery was reached at 2 weeks postinjury in the AIS grade A and B groups and at 6 months in the AIS grade C group....
Alzheimer's disease (AD) is characterized by progressive episodic memory dysfunction. A prominent hallmark of AD is gradual brain atrophy. Despite extensive research on brain pathology, the understand...
Leukodystrophies are a group of genetic diseases with diverse clinical features and prominent involvement of the central nervous system white matter. We describe a 27-year-old man who presented with a...
The detection of spinal cord lesions in patients with MS is challenging. Recently, the 3D MP2RAGE sequence demonstrated its usefulness at 3T. Benefiting from the high spatial resolution provided by ul...
Seventeen patients with MS participated in this study. They were examined at both 3T and 7T. The MR imaging examination included a Magnetic Imaging in MS (MAGNIMS) protocol with an axial T2*-WI gradie...
A total of 55 lesions were detected. The absolute number of visible lesions differed among the 4 sequences (linear mixed effect ANOVA,...
The 7T MP2RAGE sequences detected more lesions than the 3T sets. Isotropic and anisotropic acquisitions performed comparably. Ultra-high-resolution sequences obtained at 7T improve the identification ...
Susceptibility-weighted imaging (SWI) has been extensively studied in the brain and in diseases of the central nervous system such as multiple sclerosis (MS) providing unique opportunities to visualiz...
Based on our previous findings of enlarged spinal vessels in MS compared to healthy controls (HCs), we developed high-field SWI acquisition and processing methods for the cervical spinal cord with app...
In this retrospective, exploratory pilot study conducted between March 2021 and March 2022, we scanned 12 HCs and 9 pwMS using an optimized non-contrast 2D T2*-weighted gradient echo sequence at 7 tes...
We show improved visibility of vessels and more pronounced gray and white matter contrast in the MS group compared to HCs, hypointensities surrounding the cord in the MS cohort, and identify signal ch...
In this first study of SWI at 7T in the human spinal cord, SWI holds promise in advancing our understanding of disease processes in the cervical cord in MS....
