Progressive cervical cord atrophy parallels cognitive decline in Alzheimer's disease.

Humans Alzheimer Disease / pathology Male Female Atrophy Aged Cognitive Dysfunction / pathology Magnetic Resonance Imaging Disease Progression Cervical Cord / diagnostic imaging Aged, 80 and over
Alzheimer’s disease Atrophy Cognitive decline Magnetic resonance imaging Spinal cord

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 09 2024
Historique:
received: 21 09 2023
accepted: 10 07 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: epublish

Résumé

Alzheimer's disease (AD) is characterized by progressive episodic memory dysfunction. A prominent hallmark of AD is gradual brain atrophy. Despite extensive research on brain pathology, the understanding of spinal cord pathology in AD and its association with cognitive decline remains understudied. We analyzed serial magnetic resonance imaging (MRI) scans from the ADNI data repository to assess whether progressive cord atrophy is associated with clinical worsening. Cervical cord morphometry was measured in 45 patients and 49 cognitively normal controls (CN) at two time points over 1.5 years. Regression analysis examined associations between cord atrophy rate and cognitive worsening. Cognitive and functional activity performance declined in patients during follow-up. Compared with controls, patients showed a greater rate of decline of the anterior-posterior width of the cross-sectional cord area per month (- 0.12%, p = 0.036). Worsening in the mini-mental state examination (MMSE), clinical dementia rating (CDR), and functional assessment questionnaire (FAQ) was associated with faster rates of cord atrophy (MMSE: r = 0.320, p = 0.037; CDR: r = - 0.361, p = 0.017; FAQ: r = - 0.398, p = 0.029). Progressive cord atrophy occurs in AD patients; its rate over time being associated with cognitive and functional activity decline.

Identifiants

DOI: 10.1038/s41598-024-67389-9 PMID: 39284823
pubmed: 39284823
doi: 10.1038/s41598-024-67389-9
pii: 10.1038/s41598-024-67389-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

21595

Informations de copyright

© 2024. The Author(s).

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Auteurs

Tim M Emmenegger (TM)

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.

Raoul Seiler (R)

Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Wolfgang-Pauli-Strasse 27, 8093, Zurich, Switzerland.

Paul G Unschuld (PG)

Department of Psychiatry, University of Geneva (UniGE), 1205, Geneva, Switzerland.
Division of Geriatric Psychiatry, University Hospitals of Geneva (HUG), 1226, Thônex, Switzerland.

Patrick Freund (P)

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland. patrick.freund@balgrist.ch.
Zurich Neuroscience Center (ZNZ), Winterthurer Strasse 190, 8057, Zürich, Switzerland. patrick.freund@balgrist.ch.

Jan Klohs (J)

Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Wolfgang-Pauli-Strasse 27, 8093, Zurich, Switzerland. jan.klohs@bruker.com.
Zurich Neuroscience Center (ZNZ), Winterthurer Strasse 190, 8057, Zürich, Switzerland. jan.klohs@bruker.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Moelle cervicale › Progressive cervical cord atrophy parallels...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Progressive cervical cord atrophy parallels...