Clinical impact of admission urinary 8-hydroxydeoxyguanosine level for predicting cardiovascular mortality in patients with acute coronary syndrome.
8-Hydroxy-2'-Deoxyguanosine
/ analogs & derivatives
Acute Coronary Syndrome
/ diagnosis
Aged
Aged, 80 and over
Biomarkers
/ urine
Echocardiography
Female
Follow-Up Studies
Humans
Japan
/ epidemiology
Male
Middle Aged
Patient Admission
Predictive Value of Tests
Prognosis
Prospective Studies
ROC Curve
Risk Assessment
/ methods
Risk Factors
Survival Rate
/ trends
8-Hydroxydeoxyguanosine
Acute coronary syndrome
Oxidative stress
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
08
05
2020
accepted:
03
07
2020
pubmed:
8
7
2020
medline:
17
6
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
The aim of the present study was to determine whether urinary 8-hydroxydeoxyguanosine (8-OHdG), which is a marker of oxidative stress, can predict future cardiovascular death in patients with acute coronary syndrome (ACS). A total of 551 consecutive patients with ACS who underwent admission urinary 8-OHdG measurements were enrolled in this study. The patients were divided into 2 groups according to the optimal cutoff value of admission urinary 8-OHdG determined by a receiver-operating characteristics curve for the prediction of cardiovascular death: a high admission urinary 8-OHdG group, 169 patients with admission urinary 8-OHdG ≥ 17.92 ng/mg creatinine; and a low admission urinary 8-OHdG group, 382 patients with admission urinary 8-OHdG < 17.92 ng/mg creatinine. The patients were followed up for a median period of 34 months. The primary and secondary end points were the incidence of cardiovascular death and major cardiovascular events (MACE) composed of cardiovascular death, non-fatal myocardial infarction, or urgent hospitalization for heart failure. Of the 551 patients, cardiovascular deaths and MACE occurred in 14 (2.5%) and 35 (6.4%), respectively. The Kaplan-Meier estimate of the event-free rate revealed cardiovascular deaths and MACE were more likely in the high admission 8-OHdG group than in the low admission 8-OHdG group (log rank, both P < 0.001). Multiple adjusted Cox proportional hazards analysis indicated that high admission urinary 8-OHdG was an independent predictor of cardiovascular death (hazard ratio [HR] 7.642, P = 0.011) and MACE (HR 2.153, P = 0.049). High admission urinary 8-OHdG levels predict cardiovascular mortality after adjustment in patients with ACS.
Identifiants
pubmed: 32632553
doi: 10.1007/s00380-020-01663-4
pii: 10.1007/s00380-020-01663-4
doi:
Substances chimiques
Biomarkers
0
8-oxo-7,8-dihydrodeoxyguanine
6957-76-2
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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