Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study.

Adult Aged Cardiovascular Diseases Cohort Studies Female Humans Male Middle Aged Prospective Studies Thyroid Function Tests Thyroid Gland Thyrotropin Thyroxine Triiodothyronine
Biomarker Cohort study Euthyroid General population Mortality risk Thyroid function

Journal

Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444

Informations de publication

Date de publication:
02 2021
Historique:
received: 07 04 2020
accepted: 18 06 2020
pubmed: 8 7 2020
medline: 9 7 2021
entrez: 8 7 2020
Statut: ppublish

Résumé

Although thyroid hormones are irrefutably implicated in cardiovascular physiology, the impact of within-reference range variations of thyroid function on cardiovascular disease (CVD) remains unclear. Elucidating this is important, since it could foster preventive treatment and reduce global CVD burden. We therefore investigated the impact of within-reference range variations of thyroid function on all-cause and cardiovascular mortality. We included community-dwelling individuals aged 28-75 years from a prospective cohort study, without known use of thyroid-affecting therapy and with thyrotropin within reference range. Associations of thyroid function with mortality were quantified using Cox models and adjusted for sociodemographic and cardiovascular risk factors. Mean (SD) age of the 6,054 participants (52.0% male) was 53.3 (12.0) years. During 47,594 person-years of follow-up, we observed 380 deaths from all causes and 103 from CVDs. Although higher thyrotropin was not associated with all-cause mortality (adjusted HR 1.02, 95% CI 0.92-1.14), point estimates for cardiovascular mortality diverged toward increased risk in younger (<72 years) participants (1.31, 1.00-1.72) and decreased risk in elderly (≥72 years) (0.77, 0.56-1.06). Higher free thyroxine (FT Community-dwelling elderly individuals with high-normal thyroid function are at increased risk of all-cause and cardiovascular mortality, reinforcing the need of redefining the current reference ranges of thyroid function.

Identifiants

DOI: 10.1007/s12020-020-02397-z PMID: 32632723 PMC: PMC7881952
pubmed: 32632723
doi: 10.1007/s12020-020-02397-z
pii: 10.1007/s12020-020-02397-z
pmc: PMC7881952
doi:

Substances chimiques

Triiodothyronine 06LU7C9H1V
Thyrotropin 9002-71-5
Thyroxine Q51BO43MG4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

385-396

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Auteurs

Dion Groothof (D)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. d.groothof@umcg.nl.
ORCID: 0000-0002-1886-4451

Jose L Flores-Guerrero (JL)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Hjalmar R Bouma (HR)

Department of Internal Medicine, Division of Acute Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Eke G Gruppen (EG)

Department of Internal Medicine, Division of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Arjola Bano (A)

Institute of Social and Preventive Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.

Adrian Post (A)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Jenny E Kootstra-Ros (JE)

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Eelko Hak (E)

Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology, and Economics, University of Groningen, Groningen, The Netherlands.

Jens H J Bos (JHJ)

Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology, and Economics, University of Groningen, Groningen, The Netherlands.

Martin H de Borst (MH)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Reinold O B Gans (ROB)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Thera P Links (TP)

Department of Internal Medicine, Division of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Robin P F Dullaart (RPF)

Department of Internal Medicine, Division of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Stephan J L Bakker (SJL)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Maladies cardiovasculaires › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic endocrinien › Tests de la fonction thyroïdienne › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glande thyroide › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Thyréostimuline › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Thyroid function and risk of all-cause and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Thyronines › Tri-iodothyronine › Thyroid function and risk of all-cause and...