Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm.
Animals
Atractylodes
/ chemistry
Bronchi
/ drug effects
Cells, Cultured
Cough
/ etiology
Expectorants
/ pharmacology
Guinea Pigs
Humans
Inflammation
/ chemically induced
Inflammation Mediators
/ metabolism
Lipopolysaccharides
/ pharmacology
Mucociliary Clearance
Plant Extracts
/ pharmacology
Schisandra
/ chemistry
Sputum
/ drug effects
Atractylodis Rhizoma Alba
CKD-497
Fructus Schisandrae
TNF-α
TRPV-1
cough
interleukin-8
mucociliary clearance
phlegm
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Jul 2020
04 Jul 2020
Historique:
received:
05
06
2020
revised:
25
06
2020
accepted:
02
07
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
27
3
2021
Statut:
epublish
Résumé
Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used despite the debates on their clinical efficacy. We aimed to investigate the effects of the extract CKD-497, composed of Atractylodis Rhizoma Alba and Fructus Schisandrae, in relieving cough and facilitating expectoration of phlegm. CKD-497 was found to inhibit inflammatory mediators such as interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-treated mouse macrophages and transient receptor potential cation channel 1 (TRPV-1)-overexpressed human bronchial epithelial cells stimulated by capsaicin. CKD-497 decreased the viscosity of the mucin solution. During in vivo experiments, CKD-497 reduced coughing numbers and increased expectoration of phlegm via mucociliary clearance enhancement. Collectively, these data suggest that CKD-497 possesses potential for cough and phlegm expectoration treatment.
Identifiants
pubmed: 32635583
pii: molecules25133064
doi: 10.3390/molecules25133064
pmc: PMC7411911
pii:
doi:
Substances chimiques
CKD-497
0
Expectorants
0
Inflammation Mediators
0
Lipopolysaccharides
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chong Kun Dang Corp
ID : 0430-20200023
Références
Mol Immunol. 2013 Jan;53(1-2):161-71
pubmed: 22935106
Pharmacoeconomics. 2015 May;33(5):467-88
pubmed: 25663178
Pulm Pharmacol Ther. 2013 Oct;26(5):486-90
pubmed: 23524012
Yonsei Med J. 2015 May;56(3):819-24
pubmed: 25837191
Chest. 1993 Jan;103(1):59-63
pubmed: 8380268
Int J Mol Sci. 2019 Aug 17;20(16):
pubmed: 31426492
Molecules. 2018 Aug 27;23(9):
pubmed: 30150546
Science. 2000 Apr 14;288(5464):306-13
pubmed: 10764638
Am J Transl Res. 2019 Jan 15;11(1):199-209
pubmed: 30787979
J Ethnopharmacol. 2010 Jan 8;127(1):159-64
pubmed: 19786084
Drug Des Devel Ther. 2018 May 09;12:1195-1204
pubmed: 29785089
Am Rev Respir Dis. 1989 Jul;140(1):137-41
pubmed: 2751160
J Pharmacol Sci. 2016 Oct;132(2):138-144
pubmed: 27733273
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1276-80
pubmed: 15447941
ACS Chem Neurosci. 2019 Feb 20;10(2):996-1007
pubmed: 29944335
Pharmacogn Mag. 2014 Aug;10(Suppl 3):S494-500
pubmed: 25298665
J Allergy Clin Immunol. 2014 Mar;133(3):704-12.e4
pubmed: 24210884
Pharmaceuticals (Basel). 2016 Jul 28;9(3):
pubmed: 27483288
Chin Med. 2019 Jan 29;14:2
pubmed: 30728853
PLoS One. 2019 May 22;14(5):e0217366
pubmed: 31116792
J Sep Sci. 2016 Apr;39(7):1286-94
pubmed: 26888213
J Ethnopharmacol. 2011 Jul 14;136(3):422-7
pubmed: 20600763
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S164-S170
pubmed: 30431339
Respir Care. 2007 Sep;52(9):1134-46; discussion 1146-9
pubmed: 17716382
Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1868-902
pubmed: 8970383
Org Lett. 2003 Aug 21;5(17):3049-52
pubmed: 12916978
Respir Res. 2014 Oct 21;15:122
pubmed: 25331383
Biotechnol Adv. 2015 Dec;33(8):1582-1614
pubmed: 26281720
Int J Chron Obstruct Pulmon Dis. 2006;1(3):305-14
pubmed: 18046867
Alcohol Clin Exp Res. 2005 May;29(5):882-7
pubmed: 15897734
Chest. 2000 Oct;118(4):1142-9
pubmed: 11035690
J Biol Chem. 2016 Nov 25;291(48):24866-24879
pubmed: 27758864
Int J Chron Obstruct Pulmon Dis. 2015 Mar 06;10:475-87
pubmed: 25834415
Pulm Pharmacol Ther. 2015 Dec;35:149-51
pubmed: 26232720
J Pharmacol Exp Ther. 2003 Jan;304(1):217-22
pubmed: 12490594
Handb Exp Pharmacol. 2009;(187):277-95
pubmed: 18825346
Annu Rev Neurosci. 2001;24:487-517
pubmed: 11283319
Trends Mol Med. 2009 Jan;15(1):14-22
pubmed: 19097938
Nat Med. 1996 Jul;2(7):814-7
pubmed: 8673930