Molecular Basis of the Function of Transcriptional Enhancers.

Chromatin / genetics Enhancer Elements, Genetic / genetics Epigenesis, Genetic / genetics Gene Expression Regulation / genetics Humans Promoter Regions, Genetic / genetics
chromatin enhancer enhancer RNA epigenetic marks promoter transcription factories transcriptional bursting

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
05 07 2020
Historique:
received: 30 05 2020
revised: 03 07 2020
accepted: 03 07 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 13 4 2021
Statut: epublish

Résumé

Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.

Identifiants

DOI: 10.3390/cells9071620 PMID: 32635644 PMC: PMC7407508
pubmed: 32635644
pii: cells9071620
doi: 10.3390/cells9071620
pmc: PMC7407508
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Airat N Ibragimov (AN)

Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.

Oleg V Bylino (OV)

Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
ORCID: 0000-0002-8399-6194

Yulii V Shidlovskii (YV)

Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
I.M. Sechenov First Moscow State Medical University, 8, bldg. 2 Trubetskaya St., 119048 Moscow, Russia.
ORCID: 0000-0002-3643-9889

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Molecular Basis of the Function of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Molecular Basis of the Function of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Molecular Basis of the Function of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Molecular Basis of the Function of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Basis of the Function of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Molecular Basis of the Function of...