Temporal trends and autopsy findings of SUDEP based on medico-legal investigations in the United States.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
received:
10
06
2019
accepted:
28
01
2020
pubmed:
9
7
2020
medline:
21
10
2020
entrez:
9
7
2020
Statut:
ppublish
Résumé
To determine time trends and distinguishing autopsy findings of sudden unexpected death in epilepsy (SUDEP) in the United States. We identified decedents where epilepsy/seizure was listed as cause/contributor to death or comorbid condition on the death certificate among all decedents who underwent medico-legal investigation at 3 medical examiner (ME) offices across the country: New York City (2009-2016), San Diego County (2008-2016), and Maryland (2000-2016). After reviewing all available reports, deaths classified as definite/probable/near SUDEP or SUDEP plus were included for analysis. Mann-Kendall trend test was used to analyze temporal trends in SUDEP rate for 2009-2016. Definite SUDEPs were compared to sex- and age ±2 years-matched non-SUDEP deaths with a history of epilepsy regarding autopsy findings, circumstances, and comorbidities. A total of 1,086 SUDEP cases were identified. There was a decreasing trend in ME-investigated SUDEP incidence between 2009 and 2016 ( There was a decreasing monotonic trend in ME-investigated SUDEP incidence over 8 years, with a 28% reduction in incidence from 2009-2012 to 2013-2016. Unlike SIDS and sudden cardiac death, we found no correlation between SUDEP and the season of year or day of week. No autopsy findings distinguished SUDEP from non-SUDEP deaths.
Identifiants
pubmed: 32636323
pii: WNL.0000000000009996
doi: 10.1212/WNL.0000000000009996
pmc: PMC7605498
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e867-e877Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 American Academy of Neurology.
Références
N Engl J Med. 2010 Dec 23;363(26):2522-9
pubmed: 21175314
Heart Fail Clin. 2017 Oct;13(4):703-717
pubmed: 28865780
Epilepsia. 2014 Oct;55(10):1486-94
pubmed: 25323807
Epilepsy Res. 2006 Feb;68(2):137-43
pubmed: 16423504
Acta Paediatr. 1998 Oct;87(10):1033-8
pubmed: 9825968
Neurology. 2017 Jul 11;89(2):170-177
pubmed: 28592455
Epilepsia. 2018 Aug;59(8):e120-e124
pubmed: 29905938
Clin Neurol Neurosurg. 2017 Jul;158:82-89
pubmed: 28500925
JAMA Neurol. 2018 May 1;75(5):531-532
pubmed: 29710173
Int J Epidemiol. 2014 Dec;43(6):1969-85
pubmed: 25080530
Epilepsia. 2018 May;59(5):1074-1082
pubmed: 29663344
Epilepsy Behav. 2016 Feb;55:184-8
pubmed: 26627980
Neurology. 2018 Jul 10;91(2):e107-e111
pubmed: 29884734
Eur Heart J. 2000 Feb;21(4):315-20
pubmed: 10653679
Neurology. 2017 Aug 29;89(9):886-892
pubmed: 28768851
Epilepsia. 2018 Mar;59(3):562-572
pubmed: 29336017
Neurology. 2018 Jul 3;91(1):e55-e61
pubmed: 29858472
Epilepsia. 2012 Feb;53(2):227-33
pubmed: 22191982
Lancet Neurol. 2018 Nov;17(11):977-985
pubmed: 30219655
Neurology. 2017 Apr 25;88(17):1674-1680
pubmed: 28438841