Mesenchymal Stromal Cells, a New Player in Reducing Complications From Liver Transplantation?
cell therapy
liver
mesenchymal
stem
stromal
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
03
2020
accepted:
22
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
21
4
2021
Statut:
epublish
Résumé
In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clinical outcomes. Mesenchymal stromal cells (MSC) are a multi-potent progenitor cell population that have been utilized to modulate aberrant immune responses in acute and chronic inflammatory conditions. MSC exert an immunomodulatory effect on innate and adaptive immune systems through the release of both paracrine soluble factors and extracellular vesicles. Through these routes MSC can switch the regulatory function of the immune system through effects on macrophages and T regulatory cells enabling a switch of phenotype from injury to restoration. A key benefit seems to be their ability to tailor their response to the inflammatory environment without compromising the host ability to fight infection. With over 200 clinical trials registered to examine MSC therapy in liver disease and an increasing number of trials of MSC therapy in solid organ transplant recipients, there is increasing consideration for their use in liver transplantation. In this review we critically appraise the potential role of MSC therapy in the context of liver transplantation, including their ability to modulate reperfusion injury, their role in the reduction of medium term complications in the biliary tree and their potential to enhance tolerance in transplanted organs.
Identifiants
pubmed: 32636850
doi: 10.3389/fimmu.2020.01306
pmc: PMC7318292
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1306Subventions
Organisme : Medical Research Council
ID : MR/L017261/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Owen and Newsome.
Références
Turk J Gastroenterol. 2018 Sep;29(5):601-609
pubmed: 30260784
PLoS One. 2014 Dec 05;9(12):e112532
pubmed: 25479410
Surgery. 2014 Nov;156(5):1225-31
pubmed: 25262218
Transplant Proc. 2006 Nov;38(9):3046-51
pubmed: 17112896
Hepatology. 2008 May;47(5):1634-43
pubmed: 18395843
Trends Mol Med. 2019 Feb;25(2):149-163
pubmed: 30711482
Stem Cell Rev Rep. 2017 Oct;13(5):644-658
pubmed: 28733800
Biotechnol Lett. 2017 Apr;39(4):613-622
pubmed: 28032203
Stem Cells Int. 2019 Apr 9;2019:9628536
pubmed: 31093291
Nat Med. 2013 Jan;19(1):35-42
pubmed: 23296015
Transplantation. 2010 Dec 27;90(12):1312-20
pubmed: 21042238
Stem Cells Dev. 2019 Sep 15;28(18):1224-1235
pubmed: 31280676
Am J Transplant. 2011 Aug;11(8):1563-9
pubmed: 21668640
Blood. 2008 Jan 1;111(1):42-9
pubmed: 17928531
Transpl Immunol. 2016 Jul;37:1-9
pubmed: 27142560
Crit Care Med. 2012 Apr;40(4):1279-90
pubmed: 22336724
Cytotherapy. 2005;7(5):393-5
pubmed: 16236628
Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G163-71
pubmed: 10898759
Gastroenterology. 2008 Jun;134(7):2111-21, 2121.e1-3
pubmed: 18455168
Transplantation. 2002 Aug 15;74(3):315-9
pubmed: 12177608
Nat Cell Biol. 2001 Sep;3(9):778-84
pubmed: 11533656
Biomed Pharmacother. 2018 Jan;97:1173-1181
pubmed: 29136956
Transplantation. 2018 May;102(5):727-743
pubmed: 29485508
Langenbecks Arch Chir. 1988;373(2):127-30
pubmed: 3287073
J Hepatol. 2019 Jan;70(1):151-171
pubmed: 30266282
Bone Marrow Transplant. 2007 May;39(10):637-45
pubmed: 17369865
J Vasc Interv Radiol. 2013 Dec;24(12):1871-8
pubmed: 24144538
Stem Cells Transl Med. 2016 Mar;5(3):366-78
pubmed: 26826162
Blood. 2005 Sep 1;106(5):1755-61
pubmed: 15905186
J Immunol Res. 2018 Dec 3;2018:7283703
pubmed: 30622980
Stem Cells. 2006 Apr;24(4):1095-103
pubmed: 16282438
World J Stem Cells. 2015 Jan 26;7(1):165-73
pubmed: 25621116
Chem Biol Interact. 1991;79(2):115-36
pubmed: 1884426
Pediatr Res. 2018 Jan;83(1-2):232-240
pubmed: 29149103
Stem Cells. 2004;22(7):1338-45
pubmed: 15579651
Cytotherapy. 2019 Oct;21(10):1019-1024
pubmed: 31526643
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
Stem Cells Int. 2018 Dec 17;2018:5023925
pubmed: 30662468
J Orthop Res. 2005 Jul;23(4):882-90
pubmed: 16023004
Cell Death Dis. 2016 Jan 21;7:e2062
pubmed: 26794657
Int J Mol Sci. 2019 Jul 23;20(14):
pubmed: 31340593
Ann Surg. 1908 Oct;48(4):541-9
pubmed: 17862242
Mol Med. 2015 Mar 13;20:639-48
pubmed: 25375408
Arch Surg. 2011 Sep;146(9):1017-23
pubmed: 21930997
Stem Cells Transl Med. 2017 Dec;6(12):2053-2061
pubmed: 29178564
Stem Cells. 2015 Sep;33(9):2726-37
pubmed: 25969127
Mech Ageing Dev. 2008 Mar;129(3):163-73
pubmed: 18241911
J Exp Med. 1997 Apr 21;185(8):1481-6
pubmed: 9126928
Clin Biochem. 2007 Aug;40(12):893-9
pubmed: 17543295
Transplant Proc. 2009 Dec;41(10):4352-6
pubmed: 20005397
Blood. 2006 Feb 15;107(4):1484-90
pubmed: 16239427
J Hepatol. 2006 Apr;44(4):742-8
pubmed: 16469408
J Inflamm (Lond). 2005 Jul 26;2:8
pubmed: 16045800
Sci Rep. 2014 Apr 10;4:4645
pubmed: 24717973
Int J Artif Organs. 2002 Oct;25(10):935-8
pubmed: 12456034
Cell Tissue Bank. 2020 Mar;21(1):119-129
pubmed: 31863261
Life Sci. 2018 Dec 1;214:62-69
pubmed: 30381247
J Surg Res. 2019 Jul;239:191-200
pubmed: 30844633
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Int J Stem Cells. 2020 Mar 30;13(1):116-126
pubmed: 31887847
Sci Rep. 2018 Nov 15;8(1):16878
pubmed: 30442976
Am J Physiol Renal Physiol. 2008 Jul;295(1):F315-21
pubmed: 18480180
PLoS One. 2013;8(1):e49339
pubmed: 23372642
PLoS One. 2016 Oct 6;11(10):e0164269
pubmed: 27711256
Cochrane Database Syst Rev. 2015 Dec 15;(12):CD007606
pubmed: 26666504
Stem Cells Int. 2018 Jun 14;2018:3057624
pubmed: 30013600
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15;309(10):G791-800
pubmed: 26316587
Mol Biol Cell. 2002 Dec;13(12):4279-95
pubmed: 12475952
Am J Physiol. 1993 Dec;265(6 Pt 2):H2017-26
pubmed: 8285240
Leukemia. 2013 Feb;27(2):500-3
pubmed: 22878604
Hepatology. 2001 Feb;33(2):397-405
pubmed: 11172341
Liver Transpl. 2018 Feb;24(2):269-275
pubmed: 29272051
FASEB J. 2016 Dec;30(12):3905-3928
pubmed: 27601441
Diabetes. 2008 Sep;57(9):2393-401
pubmed: 18519803
Transplantation. 2007 Jan 15;83(1):71-6
pubmed: 17220794
J Nippon Med Sch. 2004 Aug;71(4):240-1
pubmed: 15329483
Transplant Direct. 2017 May 11;3(6):e160
pubmed: 28620644
J Biol Chem. 1992 Apr 5;267(10):6654-63
pubmed: 1637381
Liver Transpl. 2002 Sep;8(9):822-8
pubmed: 12200785
PLoS One. 2007 May 02;2(5):e416
pubmed: 17476338
Blood. 2005 Feb 15;105(4):1815-22
pubmed: 15494428
JAMA. 2012 Dec 12;308(22):2369-79
pubmed: 23117550
Blood. 2005 Apr 1;105(7):2821-7
pubmed: 15591115
Brain Circ. 2016 Jul-Sep;2(3):114-117
pubmed: 30276284
J Gastroenterol. 2019 Sep;54(9):763-773
pubmed: 31270691
BMJ Open. 2013 Sep 03;3(9):e003287
pubmed: 24002984
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17384-9
pubmed: 21960443
J Immunol. 2004 Dec 15;173(12):7115-9
pubmed: 15585830
J Transplant. 2012;2012:164329
pubmed: 22530107
Stem Cells Transl Med. 2018 Oct;7(10):731-739
pubmed: 30070065
Blood. 2005 Dec 15;106(13):4057-65
pubmed: 16118325
Stem Cells Transl Med. 2015 Aug;4(8):899-904
pubmed: 26041737
Gastroenterology. 2000 Jan;118(1):183-91
pubmed: 10611167
Adv Biochem Eng Biotechnol. 2013;130:209-66
pubmed: 22990585
Bone Marrow Transplant. 1995 Oct;16(4):557-64
pubmed: 8528172
Am J Transplant. 2015 Feb;15(2):541-6
pubmed: 25612501
Liver Transpl. 2017 Jun;23(6):791-803
pubmed: 28407355
Transplantation. 2020 Jan;104(1):e5-e7
pubmed: 31609902
Sci Rep. 2017 Jan 16;7:40758
pubmed: 28091591
Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):29-33
pubmed: 18234635
Liver Transpl. 2014 Nov;20(11):1372-82
pubmed: 25046819
Cytotherapy. 2012 Jul;14(6):657-69
pubmed: 22424216
Dent Clin North Am. 2012 Jul;56(3):549-61
pubmed: 22835537
Exp Hematol. 2003 Oct;31(10):890-6
pubmed: 14550804
Front Immunol. 2012 Jun 22;3:168
pubmed: 22737154
Cell Transplant. 2018 Sep;27(9):1340-1351
pubmed: 30056763
Br J Surg. 1989 Jul;76(7):722-4
pubmed: 2670054
BMC Med. 2014 Sep 18;12:145
pubmed: 25242656
Eur Surg. 2016;48:92-98
pubmed: 27110233
Cell Mol Immunol. 2015 Nov;12(6):708-18
pubmed: 25482073
Front Physiol. 2019 Apr 10;10:412
pubmed: 31024348
Cell Stem Cell. 2018 Jun 01;22(6):824-833
pubmed: 29859173
J Hepatol. 2017 Jul;67(1):47-55
pubmed: 28284916
Cell Death Dis. 2014 Jan 23;5:e1009
pubmed: 24457953
Sci Rep. 2017 Jun 1;7(1):2617
pubmed: 28572613
Sci Rep. 2018 Feb 12;8(1):2818
pubmed: 29434311
Stem Cells. 2003;21(1):105-10
pubmed: 12529557
Stem Cells. 2007 Feb;25(2):371-9
pubmed: 17038675
Stem Cells Dev. 2012 Sep 1;21(13):2410-9
pubmed: 22455365
Transplant Proc. 2007 Mar;39(2):573-6
pubmed: 17362785
Ann Surg. 2011 Apr;253(4):817-25
pubmed: 21475025
Cytotherapy. 2010 Sep;12(5):576-8
pubmed: 20735162
J Surg Res. 2008 Jun 1;147(1):153-9
pubmed: 17707862
Am J Transplant. 2013 Sep;13(9):2504
pubmed: 23919300
Stem Cells. 2006 Apr;24(4):1030-41
pubmed: 16253981
Transplantation. 2008 Nov 15;86(9):1283-91
pubmed: 19005411
Yonsei Med J. 2013 Sep;54(5):1293-6
pubmed: 23918585
Biochem Biophys Res Commun. 2013 Feb 8;431(2):203-9
pubmed: 23313481
PLoS One. 2012;7(10):e47559
pubmed: 23133515
Hepatology. 2012 Sep;56(3):1063-73
pubmed: 22422467
PLoS One. 2011 Apr 29;6(4):e19195
pubmed: 21559442
Front Immunol. 2018 Dec 04;9:2837
pubmed: 30564236
J Hepatol. 2013 Nov;59(5):1094-106
pubmed: 23811302
Cell Biol Int. 2017 May;41(5):466-475
pubmed: 28191696
Science. 1999 Mar 5;283(5407):1488-93
pubmed: 10066163
Nature. 2018 Sep;561(7724):455-457
pubmed: 30258150
Exp Clin Transplant. 2018 Oct;16(5):550-553
pubmed: 28847263
J Tissue Eng Regen Med. 2009 Jun;3(4):290-301
pubmed: 19309766
Stem Cells Int. 2017;2017:2352954
pubmed: 28740511
Int Rev Cell Mol Biol. 2012;298:229-317
pubmed: 22878108
J Surg Res. 2013 Aug;183(2):907-15
pubmed: 23522455