Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases.
alopecia universalis
hydroxychloroquine
treatment
Journal
The Australasian journal of dermatology
ISSN: 1440-0960
Titre abrégé: Australas J Dermatol
Pays: Australia
ID NLM: 0135232
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
11
05
2020
revised:
01
06
2020
accepted:
08
06
2020
pubmed:
9
7
2020
medline:
28
10
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The treatment outcome was retrospectively evaluated using the Severity of Alopecia Tool (SALT), and at the end of 6 months, patients with a ≥50% decrease in the SALT score were considered as strong responders, a 5%-50% decrease as intermediate responders and a <5% decrease as non-responders. The present findings indicate that hydroxychloroquine is not an effective treatment since in 5 of the 6 patients it was discontinued at the end of 6 months due to lack of hair regrowth, whereas only a 6-year-old boy responded with a SALT score change of 8% after the 12th month.
Substances chimiques
Immunologic Factors
0
Hydroxychloroquine
4QWG6N8QKH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e83-e85Informations de copyright
© 2020 The Australasian College of Dermatologists.
Références
Burroway B, Griggs J, Tosti A. Alopecia totalis and universalis long-term outcomes: a review. J. Eur. Acad. Dermatol. Venereol. 2020; 34: 709-15.
Shippey EA, Wagler VD, Collamer AN. Hydroxychloroquine: An old drug with new relevance. Cleve. Clin. J. Med. 2018; 85: 459-67.
Stephan F, Habre M, Tomb R. Successful treatment of alopecia totalis with hydroxychloroquine: report of 2 cases. J. Am. Acad. Dermatol. 2013; 68: 1048-9.
Yun D, Silverberg NB, Stein SL. Alopecia areata treated with hydroxychloroquine: A retrospective study of nine pediatric cases. Pediatr. Dermatol. 2018; 35: 361-5.
Nissen CV, Wulf HC. Hydroxychloroquine is ineffective in treatment of alopecia totalis and extensive alopecia areata: A case series of 8 patients. JAAD Case Rep. 2016; 2: 117-8.
Fernandez AP. Updated recommendations on the use of hydroxychloroquine in dermatologic practice. J. Am. Acad. Dermatol. 2017; 76: 1176-82.
Chiang C, Sah D, Cho BK et al. Hydroxychloroquine and Lichen Planopilaris: Efficacy and Introduction of Lichen Planopilaris Activity Index Scoring System. J. Am. Acad. Dermatol. 2010; 62: 387-92.
Kuznik A, Bencina M, Svajger U et al. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J. Immunol. 2011; 186: 4794-804.
Fox RI. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin. Arthritis Rheum. 1993; 23: 82-91.