Parent-specific effects on risk of developing allergic sensitization and asthma in childhood.
Adult
Age Factors
Asthma
/ diagnosis
Biomarkers
/ blood
Child
Denmark
/ epidemiology
Environmental Exposure
/ adverse effects
Fathers
Female
Humans
Hypersensitivity
/ diagnosis
Immunoglobulin E
/ blood
Infant
Longitudinal Studies
Male
Maternal Inheritance
Mothers
Paternal Inheritance
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
asthma
children
heritability
maternal effect
paternal effect
sensitization
specific IgE
total IgE
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
07
11
2019
revised:
31
03
2020
accepted:
29
04
2020
pubmed:
9
7
2020
medline:
3
11
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
Parent's history of atopic traits increases the risk of the same traits in their children, but mother's history may confer an increased risk compared to father's history. To investigate parent-specific effects on risk of developing allergic sensitization and asthma in childhood. We included 685 parent-child trios from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort. Parent's asthma was assessed by structured interviews and child's asthma was diagnosed prospectively at regular visits to the COPSAC clinic until age 6. Specific IgE and total IgE levels were measured in parents and children by age 0.5, 1.5 and 6 years. Associations between parent and child disease traits were analyzed using general estimating equations model adjusted for breastfeeding and maternal smoking during 3rd trimester. Maternal compared to paternal elevated specific IgE increased the child's risk of elevated specific IgE from 0-6 years: adjusted odds ratio (aOR)mother = 1.49 [1.09-2.03], P = .01 and aORfather = 1.32 [0.96-1.82], P = .08. Maternal elevated total IgE also increased the child's risk of elevated total IgE: adjusted relative risk (aOR)mother = 4.32 [1.51-10.8], P < .01, while a trend was observed for paternal total IgE: aORfather = 2.01 [0.76-4.82], P = .13. Individual time point analyses showed that the maternal effect was strongest in early life, whereas the parental effects were comparable by age 6. A similar parent-specific pattern was observed for the child's risk of asthma. The effect of mother's history of atopic traits on the child's risk of developing the same traits in early childhood was stronger than the effect from father's history, which was not evident before age 6. This suggests that maternal non-genetic factors seem to confer an added disease risk to the child, particularly in early life.
Sections du résumé
BACKGROUND
Parent's history of atopic traits increases the risk of the same traits in their children, but mother's history may confer an increased risk compared to father's history.
OBJECTIVE
To investigate parent-specific effects on risk of developing allergic sensitization and asthma in childhood.
METHODS
We included 685 parent-child trios from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort. Parent's asthma was assessed by structured interviews and child's asthma was diagnosed prospectively at regular visits to the COPSAC clinic until age 6. Specific IgE and total IgE levels were measured in parents and children by age 0.5, 1.5 and 6 years. Associations between parent and child disease traits were analyzed using general estimating equations model adjusted for breastfeeding and maternal smoking during 3rd trimester.
RESULTS
Maternal compared to paternal elevated specific IgE increased the child's risk of elevated specific IgE from 0-6 years: adjusted odds ratio (aOR)mother = 1.49 [1.09-2.03], P = .01 and aORfather = 1.32 [0.96-1.82], P = .08. Maternal elevated total IgE also increased the child's risk of elevated total IgE: adjusted relative risk (aOR)mother = 4.32 [1.51-10.8], P < .01, while a trend was observed for paternal total IgE: aORfather = 2.01 [0.76-4.82], P = .13. Individual time point analyses showed that the maternal effect was strongest in early life, whereas the parental effects were comparable by age 6. A similar parent-specific pattern was observed for the child's risk of asthma.
CONCLUSIONS AND CLINICAL RELEVANCE
The effect of mother's history of atopic traits on the child's risk of developing the same traits in early childhood was stronger than the effect from father's history, which was not evident before age 6. This suggests that maternal non-genetic factors seem to confer an added disease risk to the child, particularly in early life.
Substances chimiques
Biomarkers
0
Immunoglobulin E
37341-29-0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
915-921Informations de copyright
© 2020 John Wiley & Sons Ltd.
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