Update on multi-gene panel testing and communication of genetic test results.
BRCA
hereditary breast cancer
multi-gene panel
next-generation sequencing
tumor-based testing
Journal
The breast journal
ISSN: 1524-4741
Titre abrégé: Breast J
Pays: United States
ID NLM: 9505539
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
11
2019
accepted:
14
11
2019
pubmed:
9
7
2020
medline:
22
6
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
With technological advances, multi-gene panel testing has become increasingly used to identify patients at risk for hereditary breast cancer (HBC). There are currently evidence-based interventions and breast cancer screening strategies that exist for cancer prevention and early detection among patients with HBC. Moreover, in addition to the personal impact of identifying HBC, this information may be shared with at-risk family members to amplify the benefits of testing and subsequent care among those at high risk. Opportunities and challenges with the utilization of updated multi-gene panel testing for HBC, including: (a) tumor sequencing with germline consequences; (b) genetic counseling implications; and (c) strategies to improve the communication of genetic test results to family members will be reviewed. With the advances and expansion of genetic testing, all health care providers need to be updated on both the importance and complexities of HBC counseling and testing, in order to optimize patient care.
Identifiants
pubmed: 32639074
doi: 10.1111/tbj.13971
pmc: PMC7484453
mid: NIHMS1617550
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1513-1519Subventions
Organisme : NCI NIH HHS
ID : K12 CA090625
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA160056
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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