Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
Aging
/ metabolism
Animals
Behavior, Animal
Courtship
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ physiology
Female
Male
Mutation
/ genetics
Nerve Tissue Proteins
/ metabolism
Sensory Receptor Cells
/ metabolism
Signal Transduction
Social Behavior
ras GTPase-Activating Proteins
/ metabolism
ras Proteins
/ metabolism
Drosophila melanogaster
Ras
autism
gustatory sensory neurons
neural circuits
neurofibromatosis type 1
neurofibromin 1
ppk23
sensory processing
social behavior
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
26
09
2019
revised:
14
05
2020
accepted:
04
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
29
4
2021
Statut:
ppublish
Résumé
Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder associated with social and communicative disabilities. The cellular and circuit mechanisms by which loss of neurofibromin 1 (Nf1) results in social deficits are unknown. Here, we identify social behavioral dysregulation with Nf1 loss in Drosophila. These deficits map to primary dysfunction of a group of peripheral sensory neurons. Nf1 regulation of Ras signaling in adult ppk23
Identifiants
pubmed: 32640222
pii: S2211-1247(20)30837-8
doi: 10.1016/j.celrep.2020.107856
pmc: PMC7416787
mid: NIHMS1612051
pii:
doi:
Substances chimiques
Drosophila Proteins
0
NF1 protein, Drosophila
0
Nerve Tissue Proteins
0
ras GTPase-Activating Proteins
0
ras Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
107856Subventions
Organisme : NINDS NIH HHS
ID : DP2 NS111996
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD086984
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS096402
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Nat Neurosci. 2008 Jan;11(1):54-61
pubmed: 18066061
Nat Neurosci. 2011 Jun;14(6):757-62
pubmed: 21516101
Neuron. 2015 Sep 2;87(5):1036-49
pubmed: 26279475
Neuron. 2016 Dec 21;92(6):1279-1293
pubmed: 27916453
Fly (Austin). 2010 Jul-Sep;4(3):216-25
pubmed: 20519966
Am J Med Genet A. 2007 Oct 1;143A(19):2261-73
pubmed: 17726688
Nat Genet. 1996 Feb;12(2):144-8
pubmed: 8563751
PLoS One. 2007 Aug 15;2(7):e661
pubmed: 17710124
J Neurosci. 2010 Jul 28;30(30):10135-43
pubmed: 20668197
Science. 1997 May 2;276(5313):791-4
pubmed: 9115203
PLoS Biol. 2009 Aug;7(8):e1000168
pubmed: 19652700
G3 (Bethesda). 2016 Apr 07;6(4):1083-93
pubmed: 26896440
Nat Neurosci. 2008 Aug;11(8):874-6
pubmed: 18641642
Behav Brain Res. 2013 Sep 1;252:450-7
pubmed: 23792025
PLoS Genet. 2015 Nov 04;11(11):e1005611
pubmed: 26536237
Mech Ageing Dev. 2009 Aug;130(8):547-52
pubmed: 19486910
Cell. 1992 Apr 17;69(2):265-73
pubmed: 1568246
Neuron. 2016 Jul 6;91(1):168-81
pubmed: 27292538
Curr Biol. 2019 Oct 7;29(19):3216-3228.e9
pubmed: 31474539
Cell. 1990 Nov 16;63(4):843-9
pubmed: 2121370
Cell. 2012 May 25;149(5):1140-51
pubmed: 22632976
Genes Brain Behav. 2020 Feb;19(2):e12529
pubmed: 30345606
EMBO Rep. 2003 Aug;4(8):781-6
pubmed: 12855999
Curr Biol. 2006 Sep 5;16(17):R766-76
pubmed: 16950103
Neuroscience. 2014 Jun 13;270:192-202
pubmed: 24755485
Genes Dev. 2006 Dec 1;20(23):3311-23
pubmed: 17114577
Neuron. 2018 Feb 21;97(4):806-822.e10
pubmed: 29429934
Dev Med Child Neurol. 2004 Aug;46(8):553-63
pubmed: 15287247
Front Psychiatry. 2017 Jul 10;8:113
pubmed: 28740469
PLoS One. 2011;6(6):e21144
pubmed: 21731661
PLoS Genet. 2013 Nov;9(11):e1003958
pubmed: 24278035
Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168B(1):72-80
pubmed: 25388972
Dev Med Child Neurol. 2010 Jul;52(7):620-5
pubmed: 20187875
Cell Rep. 2018 Mar 27;22(13):3416-3426
pubmed: 29590612
Curr Biol. 2009 Oct 13;19(19):1623-7
pubmed: 19765987
J Cell Physiol. 2017 May;232(5):1151-1164
pubmed: 27670841
Cell. 2005 Jun 3;121(5):785-94
pubmed: 15935764
Neuroscience. 2006;137(2):637-45
pubmed: 16298082
Nat Methods. 2014 Mar;11(3):325-32
pubmed: 24363022
J Autism Dev Disord. 2010 Aug;40(8):937-45
pubmed: 20108030
Cell. 2019 Aug 8;178(4):867-886.e24
pubmed: 31398341
Front Hum Neurosci. 2016 Apr 12;10:144
pubmed: 27148004
Elife. 2015 Dec 29;4:
pubmed: 26714106
Science. 2001 Sep 21;293(5538):2251-6
pubmed: 11567138
Cell. 2013 Jul 3;154(1):89-102
pubmed: 23810192
Front Cell Neurosci. 2018 Apr 06;12:96
pubmed: 29681800
PLoS Genet. 2011 Sep;7(9):e1002281
pubmed: 21949657
Neuroscience. 2012 Mar 29;206:237-44
pubmed: 22260870
Cell. 1990 Aug 10;62(3):599-608
pubmed: 2116237
Dev Cogn Neurosci. 2018 Jan;29:151-167
pubmed: 28545994
Cell. 1990 Nov 16;63(4):835-41
pubmed: 2121369
Nature. 2000 Feb 24;403(6772):895-8
pubmed: 10706287
Brain. 1999 Mar;122 ( Pt 3):473-81
pubmed: 10094256
Arch Dermatol. 2001 Nov;137(11):1421-5
pubmed: 11708944
Sci Rep. 2015 Jan 14;5:7777
pubmed: 25586066
Cell. 2016 Jul 14;166(2):299-313
pubmed: 27293187
J Neurophysiol. 2005 Dec;94(6):3670-6
pubmed: 16093333
J Neurogenet. 2015;29(2-3):135-43
pubmed: 26100104
Evolution. 1987 Mar;41(2):294-302
pubmed: 28568760
Cell. 2014 Mar 27;157(1):187-200
pubmed: 24679535
JAMA Psychiatry. 2016 Dec 1;73(12):1276-1284
pubmed: 27760236
J Med Genet. 2014 Jan;51(1):10-20
pubmed: 24101678
Cell Rep. 2012 Jun 28;1(6):599-607
pubmed: 22813735
Neuron. 2020 Jan 22;105(2):322-333.e5
pubmed: 31810837
Mol Psychiatry. 2016 Apr;21(4):565-73
pubmed: 25962619
Dev Psychopathol. 2013 May;25(2):307-20
pubmed: 23627946
PLoS Genet. 2012;8(3):e1002587
pubmed: 22438833
Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2829-35
pubmed: 25964351
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6952-E6961
pubmed: 28760966
Elife. 2015 Nov 14;4:e11188
pubmed: 26568316
Nature. 2009 Oct 15;461(7266):987-91
pubmed: 19829381