Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
G-CaMP7
Shank
cognitive map
hippocampal CA1 region
memory
neurodevelopmental disorders
spatial learning
spatial navigation
synapses
two-photon imaging
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
03
12
2019
revised:
06
04
2020
accepted:
16
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
29
4
2021
Statut:
ppublish
Résumé
In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but the cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate in virtual reality, we find that the over-representation of reward and landmark locations are mediated by persistent and separable subsets of neurons, with distinct time courses of emergence and differing underlying molecular mechanisms. Strikingly, we find that in mice lacking Shank2, an autism spectrum disorder (ASD)-linked gene encoding an excitatory postsynaptic scaffold protein, the learning-induced over-representation of landmarks was absent whereas the over-representation of rewards was substantially increased, as was goal-directed behavior. These findings demonstrate that multiple hippocampal coding processes for unique types of salient features are distinguished by a Shank2-dependent mechanism and suggest that abnormally distorted hippocampal salience mapping may underlie cognitive and behavioral abnormalities in a subset of ASDs.
Identifiants
pubmed: 32640229
pii: S2211-1247(20)30845-7
doi: 10.1016/j.celrep.2020.107864
pmc: PMC7434948
mid: NIHMS1610245
pii:
doi:
Substances chimiques
Nerve Tissue Proteins
0
Shank2 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107864Subventions
Organisme : NIDA NIH HHS
ID : R01 DA017310
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests Y.H. was supported in part by Takeda Pharmaceutical and DWANGO.
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